37215压力测试仪是经典的7200 paw压力测试仪的升级产品,自1965年首次使用以来,该测试仪在多个学术和工业实验室为镇痛药物的开发和研究做出了贡献。
压痛仪的主要特点:
· 提供三种测试量程:250g,500g,750g
· 简单可靠:无需校准!
· 标准为砝码测试型号,可根据需要选择数字显示型号;
· 提供小鼠专用型号,测量更准确;
· 1960年代以来的经典方法:发表论文数百篇!
![](https://img1.17img.cn/17img/images/202209/uepic/3fe22c30-dc5a-46c6-9282-94e01c441146.jpg)
型号:37215型
仪器的主要操作:
· 爪子放置在带有圆形尖端的锥形推动器下方的小底座上;· 操作人员按下踏板开关,压力由小到大施加到动物的爪子上;
· 力以恒定速率增加,使得测试具备很好的可重复性;
· 动物感受到疼痛时会产生躲避反应;
· 松开踏板开关,压力立即停止;
· 在以10g为步进单位施加力;
· 采用低压同步电机,符合CE规则;
· 根据需要,可选择小鼠专用的型号;
![](https://img1.17img.cn/17img/images/202209/uepic/39eb0326-ba1e-4fb1-9cb7-051721b236ad.jpg)
数据采集:
· 经典的砝码款压痛仪数字模块相结合,可升级为数显型压痛仪;
· 数显型号更容易记录数据和读取数据;
· 传统款式和数显款式采用箱体的测试结构,测量数据一致;
· 数字显示器采用模块化设计,可以对传统款式进行升级; ![](https://img1.17img.cn/17img/images/202209/uepic/144fadcb-59ee-459f-83bd-8cc48c9adb4d.jpg)
型号:37215-BUNDLE
37215型压痛仪的主要规格 · 电源:115或230V,50/60Hz
· 功率:15W
· 操控方式:踏板开关
· 尺寸:40 x 16 x 14cm
· 重量:2.1Kg
型号和测试量程
· 37215,大鼠小鼠通用型:250g,500g,750g
· 37216,小鼠型号:125g,250g,375g
![](https://img1.17img.cn/17img/images/202209/uepic/0e23d08d-19d1-46d8-8620-af71a345427d.jpg)
压力模块
参考文献:
1. Chen, Yong, et al. "Epithelia-sensory neuron cross talk underlies cholestatic itch induced by lysophosphatidylcholine." Gastroenterology 161.1 (2021): 301-317. doi:10.1053/j.gastro.2021.03.049
2. Zhang, Run, et al. "Spinal microglia-derived TNF promotes the astrocytic JNK/CXCL1 pathway activation in a mouse model of burn pain." Brain, Behavior, and
Immunity 102 (2022): 23-39. doi:10.1016/j.bbi.2022.02.006
3. Shlomy, Iftach, et al. "Restoring tactile sensation using a triboelectric nanogenerator." ACS nano 15.7 (2021): 11087-11098. doi:10.1021/acsnano.0c10141
4. Jiang, Shan, et al. "Itch-specific neurons in the ventrolateral orbital cortex selectively modulate the itch processing." Science Advances 8.30 (2022): eabn4408. doi:
10.1126/sciadv.abn4408
5. Zabala, Alazne, et al. "P2X4 receptor controls microglia activation and favors remyelination in autoimmune encephalitis." EMBO molecular medicine 10.8 (2018):
e8743. doi:10.15252/emmm.201708743
6. Velichkova, Atanaska N., Sophie E. Coleman, and Carole Torsney. "Postoperative pain facilitates rat C-fibre activity-dependent slowing and induces thermal
hypersensitivity in a sex-dependent manner." British Journal of Anaesthesia 128.4 (2022): 718-733. doi:10.1016/j.bja.2021.10.053
7. Zhang, Ting, et al. "Preemptive intrathecal administration of endomorphins relieves inflammatory pain in male mice via inhibition of p38 MAPK signaling and
regulation of inflammatory cytokines." Journal of neuroinflammation 15 (2018): 1-14. doi:10.1186/s12974-018-1358-3
8. Joksimovic, Sonja L., et al. "Selective inhibition of CaV3. 2 channels reverses hyperexcitability of peripheral nociceptors and alleviates postsurgical pain." Science
signaling 11.545 (2018): eaao4425. doi: 10.1126/scisignal.aao4425
9. Joksimovic, Sonja Lj, et al. "Novel neuroactive steroid with hypnotic and T‐type calcium channel blocking properties exerts effective analgesia in a rodent model
of post‐surgical pain." British Journal of Pharmacology 177.8 (2020): 1735-1753. doi:10.1111/bph.14930
10. Zhang, Wenxin, et al. "Estrogen modulation of pain perception with a novel 17β-estradiol pretreatment regime in ovariectomized rats." Biology of sex Differences
11 (2020): 1-13. doi:10.1186/s13293-019-0271-5
相关痛觉研究仪器: