Quantity size:
0.2ml
Concentration:
1mg/ml 转运蛋白2抗体 Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
Protein transport across the nucleus is a selective, multi-step process involving several cytoplasmic factors. Proteins must be recognized as import substrates, dock at the nuclear pore complex and translocate across the nuclear envelope in an ATP-dependent fashion. Two cytosolic factors centrally involved in the recognition and docking process are the karyopherin alpha 1 and karyopherin beta1 subunits. Karyopherin alpha 1 functions 转运蛋白2抗体in the recognition and targeting of substrates destined for nuclear import, while karyopherin beta 1 serves as an adapter, tethering the karyopherin alpha 1/substrate complex to docking proteins on the nuclear envelope, termed nucleoporins. Karyopherin alpha 2 has been shown to complex with Epstein-Barr virus nuclear antigen 1 (EBNA-1). Karyopherin beta 2 and karyopherin beta 2B (also designated transportin 1 and transportin 2) share 84% sequence identity at the amino acid level, however, they have been shown to have different substrate转运蛋白2抗体 specificities. Karyopherin beta 2 mediates hnRNPA1 nuclear import while karyopherin beta 2B has been implicated in the export of cellular mRNAs through complexes formed with the mRNA export factor TAP.
转运蛋白2抗体Also known as:
Importin 3; IPO3; Karyopherin beta 2b, transportin; KPNB2B; TNPO2; Transportin 2 (importin 3, karyopherin beta 2b); Transportin 2 (Importin 3, karyopherin beta 2b), isoform CRA b; Transportin 2; TRN2.
Specificity:
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Rabbit Polyclonal IgG, affinity purified by Protein A.
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Reacts with: Human, Mouse, Rat, Dog, Pig, Cow, Horse, .
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Immunogen: KLH conjugated synthetic peptide derived from human TNPO2.
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Predicted Molecular Weight: 60, 100kDa.
转运蛋白2抗体Storage:
Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
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