Rapamycin

Chemical Name:   Rapamycin

Catalogue Number:   R124000

Synonyms:   (-)-Rapamycin; AY 22989; Antibiotic AY 22989; Cypher; NSC 226080; RAPA; RPM; Rapammune; Rapamune; SIIA 9268A; Sirolimus; Wy 090217;

CAS Number:   53123-88-9

Possible CAS Number:   NA

Mol. Formula:   C51H79NO13

Appearance:   White to Off-White Solid

Melting Point:   183-185°C

Mol. Weight:   914.17

Storage:   -20°C Freezer

Stability:   No Data Available

Solubility:   Chloroform, Methanol

Boiling Point:   No Data Available

Category:   Chiral Reagents, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals

Applications:   A triene macrolide antibiotic isolated from Streptomyces hygroscopicus. Name derived from the native word for Easter Island, Rapa’Nui. Used as an immunosuppressant; antirestenotic. Sirolimus (INN/USAN), also known as rapamycin, is an immunosuppressant drug used to prevent rejection in organ transplantation; it is especially useful in kidney transplants.

References:   Martel, P.R., et al.: Can. J. Physiol. Pharmacol., 55, 48 (1977), Carlson, R.P., et al.: J. Pharmacol. Exp. Ther., 266, 1125 (1993), Kahan, B.D., et al.: Lancet, 356, 194 (2000), Holmes, D.R., et al.: Circulation, 109, 634 (2004),