Bergamottin

Chemical Name:   Bergamottin

Catalogue Number:   B318400

Synonyms:   4-[[(2E)-3,7-Dimethyl-2,6-octadien-1-yl]oxy]-7H-furo[3,2-g][1]benzopyran-7-one; (E)-4-[(3,7-dimethyl-2,6-octadienyl)oxy]-H-furo[3,2-g][1]benzopyran-7-one; 5-Geranoxypsoralen; Bergamotine; Bergaptin;

CAS Number:   7380-40-7

Possible CAS Number:   NA

Mol. Formula:   C21H22O4

Appearance:   Off-White to Pale Yellow Solid

Melting Point:   53-55°C

Mol. Weight:   338.4

Storage:   -20?C Freezer

Stability:   No Data Available

Solubility:   Chloroform, DMSO, Methanol

Boiling Point:   No Data Available

Category:   Amines, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals

Applications:   Bergamottin (BG), a component of grapefruit juice, is a mechanism-based inactivator of CYP3A4 and contributes, in part, to the grapefruit juice-drug interaction.

References:   Bailey, D., et al.: Clin. Pharmacol. Ther., 68, 468 (2000), Guo, L., et al.; Drug Metab. Dispos., 28, 766 (2000), Baer, B., et al.: Chem. Res. Toxicol., 20, 954 (2007), Lin, H., et al.: Drug Metab. Dispos., 39, 24 (2011);