信号转导和转录激活因子5抗体详细说明

名称:信号转导和转录激活因子5抗体 

别名：signal transducers and activators of transduction 5; MGF; Signal Transducer and Activator of Transcription 5A; STAT 5; STAT 5A; STAT 5B; STAT5; STAT5A; STAT5B; Transcription factor STAT5A; STA5A_HUMAN. 

浓度：1mg/1ml 

规格：0.1ml/100μg  0.2ml/200μg 

抗体来源：Rabbit  

克隆类型：polyclonal 

交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit 

产品类型：一抗    

研究领域：免疫学 信号转导 转录调节因子  

蛋白分子量：predicted molecular weight: 90kDa 

性状：Lyophilized or Liquid 

免疫原：KLH conjugated synthetic peptide derived from human STAT 575-125aa 

亚型：IgG 

纯化方法：affinity purified by Protein A 

储存液：0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide 

产品应用：WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍：The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.

Subunit : Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts with NCOA1 and SOCS7. Interacts with ERBB4.

Subcellular Location : Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.

Similarity : Belongs to the transcription factor STAT family.

Contains 1 SH2 domain.

Database links : 

UniProtKB/Swiss-Prot: P42229.1 

Entrez Gene: 6776 Human 

Entrez Gene: 6777 Human 

Entrez Gene: 20850 Mouse 

Entrez Gene: 20851 Mouse 

Entrez Gene: 24918 Rat 

Entrez Gene: 25126 Rat 

Omim: 601511 Human 

Omim: 604260 Human 

转录调节因子（Transcriptin Regulators）

STAT-信号转导和转录激活因子蛋白家族是近年来发现的一类转录因子.通过JAK-STAT途径介导许多由细胞因子诱导的反应,参与细胞的信号转导和转录。