α-中连蛋白抗体
[别名：a-Internexin; Alpha-Internexin; Alpha-Internexin; 66 kDa neurofilament protein; Alpha Inx; INA; Internexin neuronal intermediate filament protein alpha; MGC12702; NEF 5; NEF5; Neurofilament 5 (66kD); Neurofilament 66; Neurofilament 66 tax binding protein; NF 66; NF-66; TXBP 1; TXBP1.
产品介绍:α-中连蛋白抗体Neurofilaments can be defined as the intermediate or 10nm diameter filaments found in neuronal cells. They are composed a mixture of subunits which often includes the neurofilament triplet proteins, NFL, NFM and NFH. Neurofilaments may also include peripherin, alpha internexin, nestin and in some cases vimentin. Alpha internexin is a class IV neuronal intermediate filament that is able to self assemble. It is involved in the morphogenesis of neurons and found predominantly in the adult central nervous system. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NFL to form the filamentous backbone to which NFM and NFH attach to form the cross bridges. Antibodies to alpha internexin are therefore unique probes to study and classify neuronal types and follow their processes in sections and in tissue culture. In addition the very early developmental expression of alpha internexin means its presence is an early and convenient diagnostic feature of neuronal progenitors cells and other cell committed to the neuronal lineage. In addition recent studies show a marked up regulation of alpha internexin during neuronal regeneration.
Function : Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NF-L to form the filamentous backbone to which NF-M and NF-H attach to form the cross-bridges.
Subcellular Location : Cytoplasmic
Tissue Specificity : Found predominantly in adult CNS.
Post-translational modifications : O-glycosylated (By similarity).
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity : Belongs to the intermediate filament family.
规格：多种抗体规格提供
贮存： 贮存于-20℃
纯化方法：亲和纯化的蛋白
研究领域：细胞生物 免疫学 锌指蛋白
产品应用比例：WB=1:100-500 Elisa=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1/20-1/100
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