脑红蛋白/神经血红蛋白/神经球蛋白抗体
[别名：neuroglobin; NGB; NGB_MOUSE.
[产品介绍：脑红蛋白/神经血红蛋白/神经球蛋白抗体Neuroglobin, a 151 amino acid reside protein, mainly expressed in vertebrate brain and retina, is a recently identified member of the globin superfamily. Augmenting O2 supply, neuroglobin promotes survival of neurons upon hypoxic injury, potentially limiting brain damage. Moreover, neuroglobin may be a novel oxidative stress-responsive sensor for signal transduction in the brain. Neuroglobin expression is increased by neuronal hypoxia in vitro and focal cerebral ischemia in vivo, and neuronal survival after hypoxia is reduced by inhibiting neuroglobin expression with an antisense oligodeoxynucleotide and enhanced by neuroglobin overexpression.
Function : Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis.
Subunit : Monomer. Homodimer and homotetramer; disulfide-linked (By similarity).
Subcellular Location : Perikaryon (By similarity).
Tissue Specificity : Predominantly expressed in brain, the strongest expression is seen in the frontal lobe, the subthalamic nucleus and the thalamus.
Post-translational modifications : A redox disulfide bond regulates the heme pocket coordination and the rate of nitrite reduction to NO (By similarity).
Phosphorylated in vitro by ERK1, ERK2 and PKA, and in vivo during hypoxia. Phosphorylation increases nitrite reductase activity (By similarity).
Similarity : Belongs to the globin family.
Database links : UniProtKB/Swiss-Prot: Q9ER97.1
Neuroglobin是一种在神经组织和神经冲动中携氧、转运氧气和供氧的特异性蛋白,并和神经组织微循环有关,神经球蛋白能在缺氧的环境下保护神经元.
规格：多种抗体规格提供
贮存： 贮存于-20℃
纯化方法：亲和纯化的蛋白
研究领域：细胞生物 免疫学 锌指蛋白
产品应用比例：WB=1:100-500 Elisa=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1/20-1/100
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