核因子2相关因子2抗体
[别名:Nuclear factor-E2 related factor2; Nrf-2; HEBP1; NF E2 related factor 2; NFE2 related factor 2; NFE2L2; Nrf 2; Nuclear factor erythroid 2 related factor 2; Nuclear factor erythroid derived 2 like 2; NF2L2_HUMAN.
[产品介绍:核因子2相关因子2抗体Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.
Function : Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.
Subunit : Heterodimer. May bind DNA with an unknown protein. Interacts with KEAP1. Interacts via its leucine-zipper domain with the coiled-coil domain of PMF1.
Subcellular Location : Cytoplasm, cytosol. Nucleus. Note=Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents.
Tissue Specificity : Widely expressed. Highest expression in adult muscle, kidney, lung, liver and in fetal muscle.
Post-translational modifications : Phosphorylation of Ser-40 by PKC in response to oxidative stress dissociates NFE2L2 from its cytoplasmic inhibitor KEAP1, promoting its translocation into the nucleus (By similarity).
Similarity : Belongs to the bZIP family. CNC subfamily.
Contains 1 bZIP domain.
Database links :
UniProtKB/Swiss-Prot: Q16236.3
Entrez Gene: 4780 Human
Omim: 600492 Human
SwissProt: Q16236 Human
转录调节因子(Transcriptin Regulators)核细胞系因子2相关因子Nrf2,是一种对氧化还原反应敏感的转录因子,可以通过正向促进基因的表达,来转录翻译产生一些抗氧化物,行使着异化解毒的酶类和药物的高效外排泵作用。
有学者认为:核因子2相关因子2蛋白在保护细胞免受环境毒性物质影响方面发挥着极其重要的作用,它指导某些基因促进细胞的防御工事,同时也刺激某些重要解毒酶对毒性物质,如黄曲霉素的解毒和排毒作用。
规格:多种抗体规格提供
贮存: 贮存于-20℃
纯化方法:亲和纯化的蛋白
研究领域:细胞生物 免疫学 锌指蛋白
产品应用比例:WB=1:100-500 Elisa=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1/20-1/100
公司生产的核因子2相关因子2抗体每个流程都执行严格的检测标准,保证蛋白抗原产品质量,质量稳定,实验效果明显。按理化性质和生物学功能,可将其分为IgM、IgG、IgA、IgE、IgD五类。公司产品经无数次市场验证,若出现质量问题可无条件换货或退货。本司备有上万种产品,所有生化试剂产品都具有价格绝对优势,质量保证,欢迎新老客户垂询!