6-硫鸟嘌呤
98%
Product Name: 6-Thioguanine
别名: | 6-硫鸟嘌呤 ;6-硫代鸟嘌呤,2-氨基-6-巯基嘌呤,6-巯基鸟嘌呤,2-氨基嘌呤-6(1H)-硫酮 |
CAS号: | 154-42-7 |
分子式: | C5H5N5S |
分子量: | 167.19 |
EINECS编号: | 205-827-2 |
MDL号: | MFCD00233553 |
6-硫鸟嘌呤
![](http://www.aladdin-e.com/images/items/m/T106639.gif) |
介绍: | 溶于NaOH 溶液。 |
用途: | 抗肿瘤。 |
熔点: | 360℃ |
生化和生理学机理: |
Description: IC50 Value: 0.6 mM (ID50, 24 h exposure to HL-60 cell) [1] 6-TG belongs to the thiopurine family of drugs that also include mercaptopurineand azathioprine, which are examples of antimetabolites. It is a purine analogue of the nucleobase guanine. in vitro: 6-TG was toxic to HL-60 cells (ID50 = 0.6 microM; 24-h exposure) while IFN-alpha (up to 1000 IU/ml) had minimal cytotoxic activity [1]. Paradoxically, inhibition of c-myc expression in the wild type HL-60 (HL-60/wt) cell, which is only weakly induced to differentiate by TG, was 5-fold more sensitive to the thiopurine (IC50 = 35 microM) [2]. in vivo: SOS did not occur in hypoxanthine-phosphoribosyl transferase-deficient C57Bl/6 mice, demonstrating that 6TG-SOS requires thioguanine nucleotides [3]. A higher fraction of the dose was recovered in urine as the parent thiopurine and the metabolites thiopurine riboside, thioxanthine, and thiouric acid after 6-TG treatment than after trans-AVTG treatment; cis-AVTP recovery was slightly less than that of 6-TG [4]. Clinical trial: 6-TG, Capecitabine and Celecoxib Plus TMZ or CCNU for Anaplastic Glioma Patients. Phase 2 |
6-硫鸟嘌呤
F0065 丁基琼脂糖凝胶4FF/Butyl Sepharose 4FF BR
F0065-1 丁基琼脂糖凝胶4B/Butyl Sepharose 4B BR
F0066 辛基琼脂糖凝胶4FF/Octyl Sepharose 4FF BR
F0067 DNA纯化琼脂糖凝胶FF/PlasmidSelect DNA BR
F0068 DEAE琼脂糖凝胶FF/DEAE Sepharose FF BR
F0069 Q琼脂糖凝胶FF/Q Sepharose FF 分离球蛋白4×106
F0069-1 羧甲基琼脂糖凝胶CL-6B/CM琼脂糖凝胶CL-6B/CM Sepharose CL-6B BR
F0070 羟甲基琼脂糖凝胶FF/CM琼脂糖凝胶FF/CM Sepharose FF BR
F0071 SP琼脂糖凝胶FF/SP Sepharose Fast Flow BR
F0073 镍NTA琼脂糖凝胶6FF/金属镍螯合琼脂糖凝胶6FF/Ni Sepharose 6 Fast Flow BR
F0074 螯合琼脂糖凝胶FF/螯合Sepharose FF/Chelating Sepharose FF BR
F0075 重组蛋白A琼脂糖凝胶FF/rProtein A Sepharose FF BR
F0075-1 蛋白A琼脂糖凝胶CL-4B/ProteinA SepharoseCL-4B BR
F0076 苯基琼脂糖凝胶6FF(低分辨率)/Phenyl Sepharose 6 Fast Flow (low sub) BR
F0076-1 苯基琼脂糖凝胶CL-4B/Phenyl Sepharose CL-4B BR
F0076-2 苯基琼脂糖凝胶6FF(高分辨率)/Phenyl Sepharose 6 Fast Flow (High sub) BR
F0077 蓝色琼脂糖凝胶6FF/Blue Sepharose 6FF BR
F0078 红色琼脂糖凝胶6FF/Red Sepharose 6FF BR
F0079 肝素琼脂糖凝胶6FF/Heparin Sepharose 6FF BR
F0080 肝素琼脂糖凝胶CL-6B/Heparin Sepharose CL-6B BR
F0080-1 肝素琼脂糖凝胶CL-4B/Heparin Sepharose CL-4B BR
F0081 IgG琼脂糖凝胶6FF/IgG Sepharose 6 FF BR
F0082 琼脂糖凝胶6FF/Sepharose 6FF 球蛋白分离范围~4×106
F0084 DEAE琼脂糖凝胶CL-6B/DEAE Sepharose CL-6B BR
F0085 琼脂糖凝胶CL-6B/Sepharose CL-6B 分离范围10×103~4×106
F0086 琼脂糖凝胶CL-4B/Sepharose CL-4B 分离范围70×103~20×106
F0087 琼脂糖凝胶CL-2B/Sepharose CL-2B 分离范围70×103~40×106
F0089 丙烯葡聚糖凝胶S-100 HR/Sephacryl S-100 HR 球蛋白分离范围1×103~1×105
F0090 丙烯葡聚糖凝胶S-200 HR/Sephacryl S-200 High resolution 球蛋白分离范围5×103~2.5×105;葡聚糖分离范围1×103~8×104
F0091 丙烯葡聚糖凝胶S-300 HR/Sephacryl S-300 High resolution 球蛋白分离范围1×104~1.5×106;葡聚糖分离范围2×103~4×105
F0092 丙烯葡聚糖凝胶S-400 HR/Sephacryl S-400 High resolution 球蛋白分离范围2×104~8×106;葡聚糖分离范围1×104~2×106
F0093 丙烯葡聚糖凝胶S-500 HR/Sephacryl S-500 High resolution 葡聚糖分离范围4×104~2×107
F0094 丙烯葡聚糖凝胶S-1000 SF/Sephacryl S-1000 Superfine 葡聚糖分离范围5×105~1×108
F0097 蓝色葡聚糖2000/兰色葡聚糖2000/Dextran blue 2000 BR,分子量200万
F0098 DEAE葡聚糖/DEAE Dextran 高纯,分子量50万
F0099 葡聚糖/右旋糖酐/葡聚精/Dextran BR,分子量10万-20万
F0100 葡聚糖T3/葡聚糖D3/右旋糖酐3/Dextran T3 BR,分子量3000
F0101 葡聚糖T4/葡聚糖D4/右旋糖酐4/Dextran T4 BR,分子量4000
F0102 葡聚糖T5/葡聚糖D5/右旋糖酐5/Dextran T5 BR,分子量5000
F0103 葡聚糖T6/葡聚糖D6/右旋糖酐6/Dextran T6 BR,分子量6000
F0104 葡聚糖T7/葡聚糖D7/右旋糖酐7/Dextran T7 BR,分子量7000
F0105 葡聚糖T9/葡聚糖D9/右旋糖酐9/Dextran T9 BR,分子量9000
F0106 葡聚糖T10/葡聚糖D10/右旋糖酐10/Dextran T10 BR,分子量1万
F0107 葡聚糖T11/葡聚糖D11/右旋糖酐11/Dextran T11 BR,分子量1.1万
F0108 葡聚糖T20/葡聚糖D20/右旋糖酐20/Dextran T20 BR,分子量2万
F0109 葡聚糖T40/葡聚糖D40/右旋糖酐40/Dextran T40 BR,分子量4万
F0110 葡聚糖T50/葡聚糖D50/右旋糖酐50/Dextran T50 BR,分子量5万
F0111 葡聚糖T70/葡聚糖D70/右旋糖酐70/Dextran T70 BR,分子量7万
F0112 葡聚糖T100/葡聚糖D100/右旋糖酐100/Dextran T100 BR,分子量10万
F0113 葡聚糖T110/葡聚糖D110/右旋糖酐110/Dextran T110 BR,分子量11万
F0114 葡聚糖T200/葡聚糖D200/右旋糖酐200/Dextran T200 BR,分子量20万
F0115 葡聚糖T500/葡聚糖D500/右旋糖酐500/Dextran T500 BR,分子量50万
F0115-1 葡聚糖T1000/葡聚糖D1000/右旋糖酐1000/Dextran T1000 BR,分子量100万
F0116 葡聚糖T2000/葡聚糖D2000/右旋糖酐2000/Dextran T2000 BR,分子量200万
F0117 聚蔗糖70/菲可70/蔗糖与环氧氯丙烷的聚合物/蔗糖与氯甲基环氧乙烷的聚合物/Ficoll70 BR,分子量7万
F0118 聚蔗糖400/菲可400/蔗糖与环氧氯丙烷的聚合物/蔗糖与氯甲基环氧乙烷的聚合物/Ficoll400 BR,分子量40万
F0119 细胞分离液/Percoll BR