细胞毒性受体NK-p30抗体
产品标准
浓缩液(1mg/1ml) 亲和纯化抗体
细胞毒性受体NK-p30抗体产品应用
WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 (石蜡切片需做抗原修复)
细胞毒性受体NK-p30抗体产品介绍
细胞毒性受体家族(NCRs)主要有:NKp46、NKp44和NKp30,其中NKp46和NKp30表达于所有静止和活化的NK细胞,而NKp44则选择性的表达于活化的NK细胞。靶细胞上的配体分子与NCRs的结合(交联)引发NK细胞的活化导致靶细胞的裂解和大量细胞因子的产生。现已确认NKp46和NKp44可以识别病毒上的配体分子红血球凝聚素,而NKp46则能识别肿瘤细胞上的乙酰硫酸多聚糖。
NCR3 is a cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. It is a member of the Ig superfamily and may cooperate with NKp46 and NKp44 in the induction of cytotoxicity against a variety of target cells and is selectively expressed by all NK cells, both freshly isolated and cultured in IL2, thus representing an optimal marker for NK cell identification. Similar to NKp46 and CD16, NKp30 associated with CD3 zeta chains becomes tyrosine phosphorylated following cell treatment with pervanadate. Its extracelluar portion is characterized by a single domain of the V-type and by a region rich in hydrophobic amino acids, potentially involved in protein/protein interactions that connects the Ig V-like domain with the transmembrane portion. It is selectively expressed by all resting and activated NK cells and weakly expressed in spleen.
mol wt:22kDa
Other Aliases:
Natural killer cell p30-related protein; natural cytotoxicity triggering receptor 3; 1C7; CD337; LY117; MALS; NKp30; NK receptor 1c7; 1c7 protein.
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细胞毒性受体NK-p30抗体
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企业名称
上海信裕生物技术有限公司
企业信息已认证
企业类型
信用代码
310112001202097
成立日期
2012-08-17
注册资本
50
经营范围
上海信裕生物技术有限公司
公司地址
上海市松江区新九广场卖新公路2077号3楼8306室
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