细胞因子信号传导抑制蛋白2抗体

 细胞因子信号传导抑制蛋白2抗体

产品标准

浓缩液(1mg/1ml) 亲和纯化抗体

产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500    （石蜡切片需做抗原修复）

细胞因子信号传导抑制蛋白2抗体产品介绍

    Socs2(suppressor of cytokine signaling 1) 细胞因子信号传导抑制蛋白(suppressor of cytokine signaling, SOCS)家族是一类由细胞产生并反馈性阻断细胞因子信号转导过程的负性调节因子，SOCS2可抑制IL-6、LIF、OSM、INF-γ以及GH等多种细胞因子的信号转导，对体内多种免疫反应的激活起调控作用。SOCS2异常表达与多种疾病的发病相关，在急慢性白血病、类风湿性关节炎、肝硬化和肝癌的发病中起重要作用；对信号转导，特别是JAKSTAT通路的负调控作用已被肯定。 

    The eight members of the recently identified Suppressor of Cytokines Signalling (SOCS) family are SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS6, SOCS7, and CIS. Structurally the SOCS proteins are composed of an N-terminal region of variable length and amino acid composition, a central SH2 domain, and a C-terminal motif called the SOCS box. The SOCS proteins appear to form part of a classical negative feedback loop that regulates cytokine signal transduction. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signalling in different ways.细胞因子信号传导抑制蛋白2抗体
    SOCS2 is capable of inhibiting cytokine signalling by interleukin-6 (IL-6) and growth hormone. SOCS2 interacts with the phosphorylated insulin-like growth factor (IGF-I) receptor, where it may play a regulatory role in cellular growth, differentiation, and inhibition of apoptosis via the Ras and PI3K signalling pathways. In humans, SOCS2 mRNA is expressed widely in both foetal and adult tissues, including foetal kidney and adult heart, skeletal muscle, pancreas, and liver. In rats, SOCS2 mRNA exhibits high levels of expression in liver and heart, and in the mouse nervous system, SOCS2 is expressed exclusively by neurons, where it is switched on developmentally in concordance with neuronal differentiation. 

    Accumulating evidence demonstrates that cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules Termed SOCS (Suppressor of Cytokine Signaling). To date, there are eight members of SOCS family have been recognized, they are SOCS 1, 2, 3, 4, 5, 6, 7 and CIS. Structurally the SOCS proteins are composed of an N-terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminal motif that we have called the SOCS box. The SOCS proteins appear to form part of a classical negative feed back loop that regulates cytokine signal transduction via a STAT induced transcriptional mechanism. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. SOCS 2, not like SOCS 1 and SOCS 3, regulates postnatal growth, likely through its ability to influence the GH / IGF 1axis, although they might have overlapping actions. 

    mol wt:23kDa 
    Other Aliases: 
    suppressor of cytokine signaling 2; suppressor of cytokine signaling SOCS2; CIS2; Cish2; SSI-2; SOCS2; STATI2

xy-2183xy Claudin-11 peptide少突胶质细胞跨膜蛋白抗原

xy-0790xy CLDN1(Claudin 1)C-term紧密连接蛋白1抗原(C端)

xy-0582xy COX-1 (Prostaglandin-endoperoxide synthase-1)前列腺素氧化环化酶1抗原

xy-2047xy CPT1A peptide肉毒碱棕榈酰基转移酶1A多肽抗原

xy-1790xy CRMP2/Dpysl2(collapsin response mediator protein-2)二氢嘧啶酶样2CRMP2抗原

xy-1860xy CRLR/CALCRL(calcitonin receptor like precursor)降钙素受体样蛋白抗原

xy-1703xy cRaf/Raf1(c-raf 1)cRaf/Raf1抗原

xy-1433xy MEK1/MAPKK1(mitogen activated protein kinase kinase 1)MEK1/MAPKK1抗体(N-端)

xy-0382xy CRF (Corticotropin-Releasing Factor)促肾上腺皮质激素释放因子

xy-0793xy CSIG(cellular senescence inhibited gene)细胞衰老抑制基因抗原

xy-0848xy Anti-CSP (circumsporozoite protein/Plasmodium yoelii)环子孢子蛋白(约氏疟原虫)抗原

xy-2174xy Calcitonin降钙素抗原

xy-1410xy CTBP1(C-terminal binding protein 1)C端结合蛋白1抗原

xy-1179xy CTLA-4/CD152淋巴细胞相关抗原4/细胞毒性T细胞抗原-4

细胞因子信号传导抑制蛋白2抗体

xy-0799xy CTn1 (cardiac troponin 1)心肌肌钙蛋白

xy-1376xy Cx32(Connexin-32)间隙连接蛋白32抗原

xy-1266xy CX36 (Connexin-36)间隙连接蛋白36抗原

xy-1050xy Cx40 (Connexin-40)间隙连接蛋白40(多肽)

xy-0811xy cx3cl1(chemokine (C-X3-C motif) ligand 1)趋化因子(C-X3-C 基元)配体1抗原

xy-1728xy CX3CR1(CX3C-chemokine receptor 1)CX3C趋化因子受体1抗原

xy-0571xy Cyclin A周期素A抗原

xy-0572xy Cyclin B1周期素B1抗原

xy-1148xy Cyclin D2周期素D2抗原

xy-0660xy Cyclin D3(C-term)周期素D3抗原

xy-1742xy CYP3A4(Cytochrome p450 3A4)细胞色素P450 3A4抗原

xy-1290xy Cyr61/IGFBP10/CCN1(cysteine rich 61)富半胱氨酸肝素结合蛋白61抗原

xy-0896xy HCMV UL23/HHV5 UL23(Human Cytomegalovirus UL23 Gene)人巨细胞病毒UL23抗原

xy-1007xy DAD1 (dopamine D1 receptor)多巴胺受体-D1抗原

xy-1743xy DRD3 receptor(dopamine D3 receptor)多巴胺受体-D3抗原

xy-1746xy DRD4 receptor peptide多巴胺受体-D4抗原

xy-1747xy DRD5 receptor(dopamine D5 receptor)多巴胺受体-D5抗原

xy-0596xy DBH (Dopamine- Beta-Hydroxylase)多巴胺β羟化酶（抗原）

xy-0592xy DCC (Deleted in colorectal cancer gene)结直肠癌缺失基因抗原

xy-1269xy DCX(Doublecortin)双皮质素抗原

xy-2599xy DDB2(DNA damage-binding protein 2)损伤DNA结合蛋白2抗原