缺氧诱导因子2α 抗体

缺氧诱导因子2α 抗体

产品标准

浓缩液(1mg/1ml) 亲和纯化抗体

缺氧诱导因子2α 抗体产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500    （石蜡切片需做抗原修复）

缺氧诱导因子2α 抗体产品说明

   HIF-2α也是机体对缺氧适应性调节中的重要调控蛋白.有学者认为：HIF-2α对肿瘤的能量代谢和新血管生成有促进作用,微血管的形成可抑制肿瘤细胞的凋亡,从而促进肿瘤的恶性发展。

    Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD. Also known as Hypoxia-inducible factor -2α; Hypoxia-inducible factor 2 alpha; HIF-2 alpha; Endothelial PAS domain-containing protein 1; EPAS-1; HIF-1 alpha-like factor; MHLF; HIF-related factor; HRF; MOP2; Hif2a.
    [SUBUNIT] Efficient DNA binding requires dimerization with another bHLH protein. Heterodimerizes with ARNT. Interacts with CREBPB.
    [SUBCELLULAR LOCATION] Nucleus (Potential).
    [TISSUE SPECIFICITY] Expressed in most tissues, with highest levels in lung, followed by heart, kidney, brain and liver. Predominantly expressed in endothelial cells. Also found in smooth muscle cells of the uterus, neurons, and brown adipose tissue. High expression in embryonic choroid plexus and kidney glomeruli.
    [DEVELOPMENTAL STAGE] In day 11 embryo, expression is almost exclusively seen in endothelial cells of the intersegmental blood vessels separating the somites, the atrial and ventricular chambers of the heart, and the dorsal aorta. High expression also occurs in extraembryonic membranes. In the developing brain of day 13 embryo, endothelial cells of the highly vascularized choroid plexus contain high levels of EPAS1.
    [PTM] In normoxia, is probably hydroxylated on Pro-405 and Pro-530 by EGLN1/PHD1, EGLN2/PHD2 and/or EGLN3/PHD3. The hydroxylated prolines promote interaction with VHL, initiating rapid ubiquitination and subsequent proteasomal degradation. Under hypoxia, proline hydroxylation is impaired and ubiquitination is attenuated, resulting in stabilization (By similarity).
    [PTM] In normoxia, is hydroxylated on Asn-851 by HIF1AN thus probably abrogating interaction with CREBBP and EP300 and preventing transcriptional activation.
[    PTM] Phosphorylated on multiple sites in the CTAD.
    [PTM] The iron and 2-oxoglutarate dependent 3-hydroxylation of asparagine is (S) stereospecific within HIF CTAD domains.
    [SIMILARITY] Contains 1 basic helix-loop-helix (bHLH) domain.
    [SIMILARITY] Contains 1 PAC (PAS-associated C-terminal) domain.
    [SIMILARITY] Contains 2 PAS (PER-ARNT-SIM) domains

xy-0778xy Thy-1/CD90CD90

xy-0632xy Thioster-containing protein 1硫酯包含蛋白-1(抗原)

xy-0640xy TIGAR humen (TP53- induced glycolysis and apoptosis-regulator )P53诱导糖酵解和凋亡调节因子蛋白（抗原）

xy-0418xy TIMP-4(Tissue Inhibitor of Metalloproteinase-4)金属蛋白酶组织抑制因子-4(抗原)缺氧诱导因子2α 抗体

xy-0447xy TPO(Thyroid Peroxidase)甲状腺过氧化物酶(抗原)

xy-0460xy TSHR (Thyroid stimulating hormone receptor)促甲状腺素受体（抗原）

xy-0449xy TSLP(Thymic stromal lymphopoietin isoform 1)淋巴细胞生成素-1（抗原）

xy-0446xy TTF-2(thyroid transcription factor 2;forkhead box E1)甲状腺转录因子-2(抗原)

xy-0819xy Tyrosinase酪氨酸酶(多肽抗原)

xy-0603xy OAT4L又称URAT1 (Urate Transporter 1)尿酸盐重吸收转运子1 (抗原)

xy-0853xy VAP1(vascular adhesion protein 1)血管粘附蛋白1（多肽抗原）

xy-0756xy Vimentin波形蛋白（抗原）

xy-0479xy VSIG4 (V-set and immunoglobulin domain-containing protein 4)VSIG4 T淋巴细胞负调节蛋白之一（抗原）

xy-0429xy WNK4(Ser/Thr-protein kinase WNK4; protein kinase with no lysine 4; protein kinase, lysine –dficient 4)一种新的丝氨酸/苏氨酸激酶家族成员的基因WNK4（多肽抗原）

xy-0628xy ZNF300 (zinc finger protein ZNF300)- middle锌指蛋白300(抗原)

xy-0625xy ZNF268 (zinc finger protein ZNF268)- N-terminal (1a)锌指脂蛋白-1a(抗原)

xy-0626xy ZNF268 (zinc finger protein ZNF268)- middle (1b)锌指脂蛋白-1b(抗原）

xy-0627xy ZNF268 (zinc finger protein ZNF268)- middle (1c)人锌指脂蛋白-1c(抗原)

xy-0480xy IFN- Gamma(Interferon Gamma)Ag-mouse、rat干扰素-γ多肽抗原（大、小鼠）

xy-0784xy IFN- Beta (Interferon Beta)Anti-mouse,rat干扰素-β抗原

xy-0787xy IFN- Beta (Interferon Beta) human干扰素-β抗原

xy-0669xy PSCA前列腺干细胞抗原

xy-1176xy Agrin peptide聚集蛋白抗原

xy-3929xy ATP citrate lyase/ACLY三磷酸腺柠檬酸裂解酶

xy-0322xy AEBP1 (Adipocyte enhance binding protein 1)脂肪细胞增强结合蛋白1

xy-4002xy phospho-AMPK alpha 1(Thr172) peptaide磷酸化腺苷单磷酸活化蛋白激酶α1

Y-0133 ADM 1-52/AM 1-52/Adrenomedullin 1-52肾上腺髓质素(1-52)

xy-0112xy Amyloid protein precursor淀粉样肽前体蛋白（多肽抗原）

xy-0443xy ACTH(1-39)促肾上腺皮质激素(1-39)

xy-0471xy Adiponectin脂联素（多肽抗原）

xy-2745xy Acetyl CoA Carboxylase乙酰辅酶A羧化酶