DNA修复酶Ku70抗体

DNA修复酶Ku70抗体

产品标准

 浓缩液(1mg/1ml) 亲和纯化抗体

DNA修复酶Ku70抗体产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500    （石蜡切片需做抗原修复）

DNA修复酶Ku70抗体产品介绍

    Ku-70是一种DNA修复蛋白，当细胞在受到辐射损伤而发生DNA双链断裂时，Ku70可迅速将其修复，从而提高细胞存活率.
    Ku是一种多功能的蛋白，在许多重要的细胞生命过程中起着直接或间接的作用，如DNA双链断裂的修复，免疫球蛋白和T细胞受体V（D）J重排，免疫球蛋白构型转换，DNA复制，DNA转录的调节，同时在细胞周期的G2和M时相中起着特殊的作用.

    The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq]. 

    Ku70 heterodimerises with Ku80 to form the ATP-dependent DNA helicase II, a single stranded helicase that binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. The heterodimer plays a role in non-homologous end-joining (NHEJ) required for double-strand break repair and V(D)J recombination. It acts as the regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit (PRKDC) for DNA. The Ku70/80 heterodimer is also required for osteocalcin gene expression. 
    mol wt:61-69kDa 
    Other Aliases: 
    70 kDa subunit of Ku antigen; 70 kDa subunit of Ku antigen; ATP dependent DNA helicase 2 subunit 1; ATP dependent DNA helicase II 70 kDa subunit; CTC box binding factor 75 kDa subunit; CTC75; CTCBF; DNA repair protein XRCC6; G22P1; Ku 70; Ku autoantigen 70kDa; Ku autoantigen p70 subunit; Ku autoantigen, 70kDa; Ku p70; Ku70 DNA binding component of DNA-dependent proteinkinase complex (thyroid autoantigen 70 kDa; Kup70; Lupus Ku autoantigen protein p70; ML8; Thyroid autoantigen 70kD (Ku antigen); Thyroid autoantigen; Thyroid lupus autoantigen; Thyroid lupus autoantigen p70; TLAA; X ray repair complementing defective repair in Chinese hamster cells 6; XRCC 6; XRCC6

xy-7725R SA2粘结蛋白SA2抗体

xy-7728R SMC4染色体结构维持蛋白4抗体

xy-7724R Nuclear protein stromal antigen 1粘结蛋白SA1抗体

xy-7716R SPC25纺锤体极点构成蛋白25抗体

xy-12348R 5T4滋养层细胞糖蛋白5T4抗体

DNA修复酶Ku70抗体

xy-1657R phospho-STAT1 (Tyr701)磷酸化信号转导与转录激活因子1抗体

xy-1658R phospho-STAT3 (Tyr705)磷酸化信号转导和转录激活因子3抗体

xy-1791R phospho-STAT6 (Tyr641)磷酸化信号转导和转录激活因子6抗体

xy-3525R SIGLEC14唾液酸结合性免疫球蛋白样凝集素14抗体

xy-0089R Secretin receptor分泌素受体抗体

xy-1127R beta Sarcoglycan肌聚多糖-β抗体

xy-3433R Phospho-Syk (Tyr323)磷酸化非受体型酪氨酸蛋白激酶抗体

xy-3434R Phospho-Syk (Tyr525 + Tyr526)磷酸化非受体型酪氨酸蛋白激酶抗体

xy-0645R Rat secretory IgA分泌型免疫球蛋白A抗体

xy-1096R SKP2细胞S期激酶相关蛋白2抗体

xy-0763R Snake poison Protein蛇毒蛋白抗体（中华眼镜蛇）

xy-0495R Selenoprotein W硒蛋白W抗体

xy-0545R SCF干细胞生长因子抗体

xy-0783R SDF1 beta基质细胞衍生因子－1抗体

xy-1121R Sema3A臂板蛋白3A抗体

xy-1122R semaphorin 3F臂板蛋白3F抗体

xy-1123R Sema4C臂板蛋白4C抗体

xy-1128R SGLT1钠-糖共转运载体1抗体

xy-0211R SHANK 1富含脯氨酸突触相关蛋白SHANK1抗体

xy-1175R SHBG性激素结合球蛋白抗体

xy-1129R SHP-1造血细胞磷酸酶抗体

xy-1233R SHP2蛋白酪氨酸磷酸酶2抗体

xy-0496R SLC24A5可溶性载质转运蛋白SLC24A5抗体

xy-2121R SCYLV甘蔗SCYLV抗体

xy-2536R SREBP-2胆固醇调节元件结合蛋白2抗体

xy-2544R SLAMF7SLAMF7抗体

xy-6733R SECTM1分泌和跨膜蛋白1抗体

xy-6732R SDF4基质细胞衍生因子4抗体（钙结合蛋白）

xy-6737R SVH肝癌蛋白剪接变异体蛋白抗体

xy-7011R SDCCAG8结肠癌抗原8抗体

xy-7009R SART3T淋巴细胞识别的鳞状细胞癌SART3抗体

xy-3427R phospho-STAT1 (Ser727)磷酸化信号转导与转录激活因子1抗体

xy-6731R SDCG1血清学定义结肠癌抗原1抗体

xy-3484R Smad3细胞信号转导分子SMAD3抗体

xy-3425R Phospho-Smad3 (Ser423 + Ser425)磷酸化细胞信号转导分子SMAD3抗体

xy-7010R SDCCAG10结肠癌抗原10抗体

xy-1609R SATB1核基质结合区结合蛋白1抗体

xy-3579R SLC40A1细胞膜铁转运蛋白FP1抗体

xy-3575R SSEA3阶段特异性胚胎表面抗原-3抗体

xy-6596R STMN3原癌基因18家族STMN3蛋白抗体

xy-3609R SSEA4阶段特异性胚胎表面抗原4抗体

xy-2178R SM22 Alpha细胞骨架相关蛋白抗体

xy-0457R phospho-SMAD2(Ser425)磷酸化细胞信号转导分子SMAD2抗