P53凋亡刺激蛋白2抗体

 P53凋亡刺激蛋白2抗体

产品标准

浓缩液(1mg/1ml) 亲和纯化抗体

 P53凋亡刺激蛋白2抗体产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500    （石蜡切片需做抗原修复）

 P53凋亡刺激蛋白2抗体产品介绍

p53凋亡刺激蛋白(apoptosis stimulating protein of p53，ASPP)家族是近年来发现的一个新蛋白家族，它包括3个成员：ASPP1、ASPP2和iASPP。其中ASPP1和ASPP2能够与p53蛋白结合增强该蛋白的促进细胞凋亡的功能，发挥抑制肿瘤的作用；而iASPP与ASPP1和ASPP2的功能截然相反，它能够和ASPP1或ASPP2竞争性地与p53结合，抑制ASPP1或ASPP2的促进凋亡作用，具有癌基因的功能。三者的结构相似，但功能却完全不同，通过研究三者的关系、促进肿瘤细胞内ASPP1或ASPP2的高表达以及抑制iASPP的表达有可能促进肿瘤细胞的凋亡，成为肿瘤治疗的新靶点.

[FUNCTION] Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates p53/TP53 by enhancing the DNA binding and transactivation function of p53/TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M (By similarity).
[SUBUNIT] Binds to the central domain of p53/TP53 as well as to BCL2. Interacts with protein phosphatase 1. Interacts with RELA NF-kappa-B subunit. This interaction probably prevents the activation of apoptosis, possibly by preventing its interaction with p53/TP53. Interacts with APC2 and APPBP1 (By similarity).
[INTERACTION] P35569:Irs1; NbExp=1; IntAct=EBI-645416, EBI-400825.
[SUBCELLULAR LOCATION] Cytoplasm, perinuclear region (By similarity). Nucleus (By similarity). Note=Predominantly found in the perinuclear region (By similarity). Some small fraction is nuclear (By similarity).
[DOMAIN] The ankyrin repeats and the SH3 domain are required for specific interactions with p53/TP53 (By similarity). a
[SIMILARITY] Belongs to the ASPP family. 
[SIMILARITY] Contains 2 ANK repeats.
[SIMILARITY] Contains 1 SH3 domain

xy-5575R phospho-AMPK alpha 2 (Ser173)磷酸化腺苷单磷酸活化蛋白激酶α2抗体

xy-4158R SHP1蛋白酪氨酸磷酸酶1C抗体

 P53凋亡刺激蛋白2抗体

xy-5577R phospho-PTPN6(Tyr536)磷酸化蛋白酪氨酸磷酸酶1C抗体

xy-5578R phospho-PTPN6(Ser591)磷酸化蛋白酪氨酸磷酸酶1C抗体

xy-4159R PI 3 Kinase Class 3磷脂酰肌醇激酶3催化亚单位3抗体

xy-5580R phospho-PIK3C3(Ser676)磷酸化磷脂酰肌醇激酶3催化亚单位3抗体

xy-5581R phospho-PIK3C3(Ser164)磷酸化磷脂酰肌醇激酶3催化亚单位3抗体

xy-5585R phospho-PRKCQ(Thr538)磷酸化蛋白激酶C theta抗体

xy-4160R PI 3 Kinase p85 beta磷脂酰肌醇激酶p85β抗体

xy-5582R phospho-PIK3R2(Tyr467)磷酸化磷脂酰肌醇激酶p85β抗体

xy-5586R phospho-PPM1A(Ser375)磷酸化蛋白磷酸酶2C亚型α抗体

xy-4065R P2X2三磷酸腺苷受体受体P2X2抗体

xy-10026R Phospho-Paxillin(Ser83)磷酸化桩蛋白Paxillin抗体

xy-10092R PLAG1多型性腺瘤基因1蛋白抗体

xy-10235R Pokemon/ZBTB7扑克蒙蛋白抗体

xy-10564R Protein CASPCASP抗体

xy-10305R PIM1+PIM3丝氨酸/苏氨酸激酶蛋白PIM1+PIM3抗体

xy-13659R PACSIN3胞浆蛋白PACSIN3抗体

xy-13695R PAG1跨膜接头蛋白PAG抗体

xy-13696R PARD6GPARD6G蛋白抗体

xy-13697R PL6胎盘蛋白6抗体

xy-13675R PIK3AP1磷酸肌醇3激酶接头蛋白1抗体

xy-12676R PRAM1PRAM1蛋白抗体

xy-10403R Pan Cytokeratin/p-CK广谱细胞角蛋白PCK抗体

xy-10157R PDZ RHOGEF/GTRAP48Rho鸟甘酸转运蛋白抗体

xy-5538R phospho-PIK3R1(Tyr368)磷酸化磷脂酰肌醇激酶抗体

xy-5552R phospho-PARK2(Ser101)磷酸化帕金蛋白抗体

xy-5553R phospho-PARK2(Ser378)磷酸化帕金蛋白抗体

xy-5554R Phospho-PDGF Receptor beta (Tyr579)磷酸化血小板源性生长因子受体B抗体

xy-5555R Phospho-PDGF Receptor beta (Tyr716)磷酸化血小板源性生长因子受体B抗体

xy-4153R PAK6P21蛋白激活的蛋白激酶6抗体