8-羟基脱氧鸟苷抗体

8-羟基脱氧鸟苷抗体

产品类别

 兔抗8-羟基脱氧鸟苷蛋白抗体

8-羟基脱氧鸟苷抗体

产品标准

 浓缩液(1mg/1ml) 亲和纯化抗体

产品应用

 WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500    （石蜡切片需做抗原修复）

 8-羟基脱氧鸟苷抗体

产品介绍

    药物 化合物抗体
    8-羟基脱氧鸟苷是活性氧自由基(ROS)引起DNA氧化损伤修饰产物之一,其生成原因很多,主要是电离辐射、化学致癌物代谢活化及细胞正常新陈代谢过程产生大量ROS直接攻击DNA中的鸟嘌呤(dG),使脱氧鸟苷氧化为8-OHdG。目前已成为DNA氧化损伤中最常采用的生物标志物。
    8-Hydroxydeoxyguanosine (8OHdG) is a modified base that occurs in DNA due to attack by hydroxyl radicals that are formed as byproducts and intermediates of aerobic metabolism and during oxidative stress. There is increasing evidence to support the involvement of free radical reactions in the damage of biomolecules that eventually lead to several diseases in humans, such as atherosclerosis, cerebral and heart ischemia-reperfusion injury, cancer, rheumatoid arthritis, inflammation, diabetes, aging, and neurodegenerative conditions, such as Alzheimer's disease. 
    8OHdG has become increasing popular as a sensitive, stable and integral marker of oxidative damage in cellular DNA. Biomonitoring in humans has demonstrated that 8OHdG can be excreted in the urine, and that a significant increase is caused by exposure to tobacco smoke and ionizing radiation. Because 8OHdG is so well correlated with oxidative stress and damage to DNA, which leads to degenerative disease states, the development of an antibody that can be used to study DNA damage has numerous applications. In addition to the direct study of DNA damage within cells, this antibody has applications in the development of immunoassays that can monitor 8OHdG excretion in the urine and serve as a biomarker of oxidative stress. Industrial uses may extend to the dietary supplement manufacturers, who could benefit from an immunoassay that could be used to test the effectiveness of antioxidants and other nutraceuticals. 
    CHEMICON's new goat antiserum to 8-hydroxyguanosine is now available. This antiserum has been shown by ELISA to be completely cross-reactive with 8-hydroxydeoxyguanosine while not cross-reacting with other naturally occurring nucleotides. This antibody should be a valuable tool for scientists working to understand the role of free radical damage in a number of human disease states

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xy-3303R Phospho-PDGF Receptor beta (Tyr771)磷酸化血小板源性生长因子受体-B抗体

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xy-3523R PBKPDZ连接激酶/T-LAK细胞源蛋白激酶抗体

8-羟基脱氧鸟苷抗体

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xy-5920R PATZ1转录调节因子MAZR抗体

xy-6833R PDCD6凋亡相关蛋白6抗体

xy-12142R PATJPSD95相关紧密连接蛋白PATJ抗体

xy-12157R PDGFAA + PDGFBB血小板源性生长因子AA+BB抗体

xy-6316R PTGER1前列腺素EP1受体抗体

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xy-9352R Proteasome 20S alpha 3蛋白酶体PSMα3抗体

xy-9346R Proteasome 19S 10B蛋白酶体PRS10B抗体

xy-9347R Proteasome 26S S3蛋白酶体PSMD3抗体

xy-9370R Cerebral protein 4脑蛋白4抗体

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xy-10178R PDSS2抑癌蛋白DLP1

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xy-0101R PKM2丙酮酸激酶-M2抗体

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xy-1861R PAX5配对盒基因5抗体

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xy-1872R PIRH2泛素连接酶抗体

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xy-1867R PD-1程序性死亡1抗体

xy-1874R PRDX3过氧化还原酶3抗体

xy-1879R PSAP前列腺酸性磷酸酶抗体

xy-3537R PRAS40蛋白激酶AKT底物1抗体

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