β-连环蛋白抗体（β链接素）

 β-连环蛋白抗体（β链接素）

产品标准

浓缩液(1mg/1ml) 亲和纯化抗体

 β-连环蛋白抗体（β链接素）产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500    （石蜡切片需做抗原修复）

 β-连环蛋白抗体（β链接素）产品介绍

    细胞粘附蛋白（Call Adhesion Protein）
    β连环素蛋白β-catenin是一种多功能的蛋白质，能链接E-\N-,钙粘附分子具有参与细胞粘附和介导信号转导的双重功能，并与肿瘤的发生发展及浸润密切相关。
    在正常个体中，β-catenin和钙黏蛋白形成复合体，介导同型细胞的粘附，维持细胞的稳定；同时，β-catenin作为Wnt/β-catenin信号通路的关键成员在介导信号转导过程中调控细胞的增殖和凋亡。
    在恶性肿瘤中，β-catenin的表达呈现明显的异质性，促使细胞异常增殖，还可使细胞之间的黏附性减弱，侵袭性增强。

     This gene encodes not only an important cytoplasmic component of the classical cadherin adhesion complex that forms the adherens junction in epithelia and mediates cell-cell adhesion in many other tissues but also a key signaling molecule in the canonical Wnt signaling pathway that controls cell growth and differentiation during both normal development and tumorigenesis. The gene product contains a central armadillo-repeat containing domain through which it binds the cytoplasmic tail of classical cadherins; meanwhile, it also binds alpha-catenin, which further links the cadherin complex to the actin cytoskeleton either directly or indirectly. Beta-catenin is therefore necessary for the adhesive function of classical cadherins. Another key function of this protein is to mediate the canonical Wnt signaling pathway and regulate gene transcription. Without Wnt signal, cytoplasmic beta-catenin that is not associated with the cadherin complex is quickly phosphorylated at the N-terminal Ser/Thr residues by the so called degradation complex containing axin, adenomatous polyposis coli (APC), casein kinase I, and GSK3B, then ubiquitylated by beta-TrCP, and degraded by the proteasome. However, in the presence of Wnt signal, the degradation complex is disrupted and the stabilized cytoplasmic beta-catenin translocates into the nucleus, where it binds various transcription factors and, together with these factors, regulates the transcription of many downstream genes. Mutations of this gene have been linked with various types of tumors. Alternatively spliced variants have been found for this gene. [provided by RefSeq]. 
    mol wt:92kDa 
    Other Aliases: 
    CTNNB1; CHBCAT; CTNNB1; CTNNB; Beta-catenin; PRO2286; FLJ37923; FLJ25606; DKFZp686D02253

xy-0734R KGF纤维母细胞生长因子7抗体

xy-2772R KLF2肺Kruppel样因子抗体

 β-连环蛋白抗体（β链接素）

xy-5869R KLK5激肽释放酶5抗体

xy-5866R KLK13激肽释放酶13抗体

xy-5867R KLK15激肽释放酶15抗体

xy-5868R KLK2激肽释放酶2抗体

xy-5865R KLK12激肽释放酶12抗体

xy-2501R KiSS1 receptorG蛋白偶联受体54抗体

xy-3527R KIF17驱动蛋白家族KIF17抗体

xy-3644R KLF9转录因子KLF9抗体

xy-2531R NES/KLK10上皮细胞特异性蛋白1抗体

xy-5403R phospho-KCNC1(Ser503)磷酸化离子通道蛋白Kv3.1抗体

xy-2812R KAT4细胞周期基因1蛋白抗体

xy-2385R KLF5驱动蛋白KIF5B抗体

xy-7752R KLHL13kelch样蛋白13抗体

xy-11569R KCNN3钙激活钾通道蛋白3抗体

xy-11570R KIBRA肾脏和脑蛋白抗体

xy-7751R KIF2B有丝分裂驱动蛋白样2B抗体

xy-7753R KLHL9kelch样蛋白9抗体

xy-7804R KIF15驱动蛋白家族成员15抗体

xy-7808R KNTC1着丝点关联蛋白1抗体

xy-7806R KLHDC5kelch样蛋白5抗体

xy-7805R KIFC1驱动蛋白家族成员C1抗体

xy-7807R KLHL22Kelch样蛋白22抗体

xy-6671R KCND1电压门控钾通道Kv4.1抗体

xy-6674R KCNK3酸敏感钾离子通道蛋白3抗体

xy-2925R KlothoKlotho多肽蛋白抗体

xy-6675R KCNN4钙激活钾通道蛋白4抗体

xy-8049R KLHL23Kelch样蛋白23抗体

xy-8044R KBTBD10BTB-kelch蛋白家族10抗体

xy-8045R KBTBD4BTB-kelch蛋白家族4抗体

xy-8050R KLHL24Kelch样蛋白24抗体

xy-8048R KLHL21Kelch样蛋白21抗体

xy-8051R KLHL25Kelch样蛋白25抗体

xy-11026R Kinesin驱动蛋白KNS1抗体

xy-11033R KIF1B驱动蛋白家族成员1B抗体

xy-7851R katanin p80剑蛋白p80抗体