乳腺癌易感基因1抗体（小鼠 大鼠）

乳腺癌易感基因1抗体（小鼠 大鼠）

产品标准

浓缩液(1mg/1ml) 亲和纯化抗体

乳腺癌易感基因1抗体（小鼠 大鼠）产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500    （石蜡切片需做抗原修复）

乳腺癌易感基因1抗体（小鼠 大鼠）产品介绍

    BRCA1基因是最早被发现的乳腺癌易感基因其突变和家族性乳腺癌、卵巢癌的发病有关。
    检测人BRCA-1抗体是bs-0802R
    This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC for BRCA1-associated genome surveillance complex. This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complex. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants have been described for this gene but only some have had their full-length natures identified. Transcript Variant: This variant (BRCA1a') uses different splice site in the 5' UTR when compared to variant BRCA1a. It encodes the full-length BRCA1 protein (isoform 1) which is also known as p220. Variants BRCA1a and BRCA1b also encode the full-length BRCA1 protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. 
    mol wt:205kDa 
    Other Aliases: 
    BRAC 1; BRCA 1; BRCC 1; BRCC1; Breast Cancer 1; Breast Cancer 1 Early Onset; Breast cancer type 1 susceptibility protein; Breast Ovarian Cancer Susceptibility; IRIS; Papillary Serous Carcinoma Of The Peritoneum; PSCP; RING finger protein 53; RNF53乳腺癌易感基因1抗体（小鼠 大鼠）

xy-3123R Phospho-Cyclin B1 (Ser133)磷酸化周期素B1抗体

xy-3124R Phospho-Cyclin D1 (Thr286)磷酸化cyclin D1抗体

xy-1383R CD13CD13氨肽酶N抗体

xy-1268R CCL20/MIP3 alpha巨噬细胞炎性蛋白MIP-3a抗体

xy-1376R Connexin-32间隙连接蛋白32抗体

xy-1410R CTBP1C端结合蛋白1抗体

xy-1494R CK1+5+10+14高分子量角蛋白抗体

xy-15138R C22orf3922号染色体开放阅读框39抗体

xy-1389R Cyclin G周期素G抗体

xy-2763R Crk p38Crk p38抗体

xy-3121R phospho-Crk p38 (Tyr221)磷酸化Crk p38抗体

xy-1134R RUNX2核心结合因子α1抗体(成骨特异性转录因子)Cbfα1

xy-0764R CCK8胆囊收缩素8抗体

xy-1169R CCR-1细胞表面趋化因子受体1抗体

xy-0562R CCR-2细胞表面趋化因子受体2抗体

xy-1167R CCR3细胞表面趋化因子受体3抗体

xy-1168R CCR4细胞表面趋化因子受体4抗体

xy-0081R Caspase-3活化半胱胺酸蛋白酶蛋白-3抗体

xy-0553R Collagen VI alpha 1抗Ⅵ型胶原抗体

xy-0052R Caspase 8半胱氨酸蛋白酶8抗体

xy-9119R COPS8信号转导蛋白亚基8抗体

xy-1710R CCR10细胞表面趋化因子受体10抗体

xy-1782R Transferrin receptor转铁蛋白受体抗体

xy-1711R CNR-2钙粘蛋白相关的神经受体2抗体

xy-1681R CHK1细胞周期检测点激酶1抗体

xy-1683R CNR1钙粘蛋白相关的神经受体1抗体

xy-9236R CDX2+3尾侧型同源转录因子2/3抗体

xy-1786R Cyclin H周期素H抗体

xy-15224R C6orf156号染色体开放阅读框15抗体

xy-0215R CD95载脂蛋白A1抗体

xy-1174R CDKN2A/p14ARF抑癌基因p14抗体

xy-0740R CDKN2A/p16-INK4a抑癌基因p16抗体

xy-0742R CDKN1BP27抗体/周期素依赖激酶抑制剂

xy-15319R C9orf171 9号染色体开放阅读框171抗体

xy-15101R C20orf17720号染色体开放阅读框177抗体