乳腺癌易感基因1抗体(人)

 乳腺癌易感基因1抗体(人)

产品标准

浓缩液(1mg/1ml) 亲和纯化抗体

 乳腺癌易感基因1抗体(人)产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500    （石蜡切片需做抗原修复）

 乳腺癌易感基因1抗体(人)产品介绍

    BRCA1基因是最早被发现的乳腺癌易感基因其突变和家族性乳腺癌、卵巢癌的发病有关。
    bs-0803R 用于检测mo, rat的BRCA1
    This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC for BRCA1-associated genome surveillance complex. This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complex. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants have been described for this gene but only some have had their full-length natures identified. Transcript Variant: This variant (BRCA1a') uses different splice site in the 5' UTR when compared to variant BRCA1a. It encodes the full-length BRCA1 protein (isoform 1) which is also known as p220. Variants BRCA1a and BRCA1b also encode the full-length BRCA1 protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. 
    mol wt:205kDa 
    Other Aliases: 
    BRAC 1; BRCA 1; BRCC 1; BRCC1; Breast Cancer 1; Breast Cancer 1 Early Onset; Breast cancer type 1 susceptibility protein; Breast Ovarian Cancer Susceptibility; IRIS; Papillary Serous Carcinoma Of The Peritoneum; PSCP; RING finger protein 53; RNF53

 乳腺癌易感基因1抗体(人)

xy-4752R Classical swine fever virus猪瘟病毒抗体

xy-9832R C3orf543号染色体开放阅读框54抗体

xy-9816R C2orf432号染色体开放阅读框43抗体

xy-4746R Classical swine fever virus猪瘟病毒抗体

xy-9307R CP110中心体蛋白110抗体

xy-4549R Cellulase纤维素酶

xy-7608R CDC14B细胞分裂周期蛋白14B抗体

xy-9221R C1orf1771号染色体开放阅读框177抗体

xy-9222R C1orf1831号染色体开放阅读框183抗体

xy-4532R Clenbuterol克仑特罗/瘦肉精抗体

xy-15225R C6orf1516号染色体开放阅读框151抗体

xy-9620R C15orf5215号染色体开放阅读框52抗体

xy-9820R C2orf892号染色体开放阅读框89抗体

xy-7081R CARD10BCL10结合蛋白和激活核转录因子抗体

xy-7084R CARD15凋亡加强结构域蛋白15抗体

xy-9611R CLLD6慢性淋巴细胞白血病缺失基因6蛋白抗体

xy-9613R C13orf3813号染色体开放阅读框38抗体

xy-9614R C14ORF14014号染色体开放阅读框140抗体

xy-13883R CHAC2阳离子转运调节样蛋白2抗体

xy-9621R C15orf6215号染色体开放阅读框62抗体

xy-9619R C15orf4115号染色体开放阅读框41抗体

xy-2074R CNGA2环核苷酸阳离子通道蛋白α2抗体

xy-1693R CANX钙连蛋白抗体

xy-1790R CRMP2二氢嘧啶酶相关蛋白2抗体

xy-1725R CYP2E1细胞色素P450ⅡE1抗体

xy-1728R CX3CR1趋化因子受体1抗体

xy-1731R phospho-c-Raf(Ser338/Tyr340)磷酸化原癌基因c-Raf抗体

xy-1732R phospho C-Myc(Thr58/pSer62)磷酸化致癌基因C-Myc抗体

xy-2042R CD33CD33抗体

xy-1738R phospho-c-kit(Tyr936)磷酸化原癌基因c-kit抗体

xy-1735R phospho-c-Jun(Thr91+Thr93)磷酸化原癌基因c-Jun抗体

xy-6981R CLCN3氯离子通道蛋白3抗体

xy-3120R phospho-Cyclin E (Thr395)磷酸化周期素E抗体

xy-3096R Phospho-cdc25C (Ser216)磷酸化细胞分裂周期蛋白25C抗体

xy-3097R Phospho-CDK9 (Thr186)磷酸化周期素依赖性激酶9抗体

xy-3098R Phospho-Connexin 43 (Ser368)磷酸化Connexin 43蛋白抗体

xy-2759R cofilin丝切蛋白抗体

xy-3100R phospho-Cortactin (Tyr466)磷酸化皮层肌动蛋白抗体

xy-3122R Phospho-Cyclin B1 (Ser147)磷酸化周期素B1抗体