胆汁酸盐输出泵蛋白抗体

胆汁酸盐输出泵蛋白抗体产品标准

浓缩液(1mg/1ml) 亲和纯化抗体

产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500    （石蜡切片需做抗原修复）

胆汁酸盐输出泵蛋白抗体产品介绍

    The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt transporter in humans and mice. Mutations in the human gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. 

    Bile formation is an important function of the liver. It is mediated by hepatocytes which generate bile flow within the bile canaliculi by continuous vectorial secretion of bile salts and other solutes across their canalicular (apical) membrane. Bile secretion is mediated by several ATP-binding cassette (ABC) transporters located in the canalicular membrane of hepatocytes. Among these ABC transporters, ABCB11 (bile salt export pump or BSEP) represents the primary, if not sole transport system for the canalicular excretion of bile salts. Bile secretory failure results in cholestasis and progressive familial intrahepatic cholestasis (PFIC) in infancy represents a group of inherited cholestatic diseases that are classified into three subtypes. One of these subtypes, PFIC II, is associated with mutations in the ABCB11 gene. PFIC patients with mutations in the ABCB11 gene have normal serum gamma-glutamyltransferase activity, low concentrations of bile salts in bile, and an absence of bile duct proliferation. Additionally, human obesity is associated with altered cholesterol homeostasis including increased production and turnover, as well as secretion of excess cholesterol from the liver into bile. 
    ABCB11 is a multifunctional polypeptide with two homologous halves, each containing a hydrophobic membrane ancoring domain and an ATP binding cassette (ABC) domain. The membrane anchoring domain is composed of six helixes buried in the lipid bilayer of the plasma membrane and the ATP binding ABCs are exposed to the cytosol. The membrane anchoring domain helixes are thought to form channels spanning the plasma membrane. 
    mol wt:145kDa 
    Other Aliases: 
    Bile salt export pump; ATP binding cassette sub family B (MDR/TAP) member 11; ATP binding cassette sub family B member 11; Bsep; Sister of P glycoprotein; Spgp; Abcb11; ABC16; Lith1; PFIC2; PGY4

胆汁酸盐输出泵蛋白抗体

hz-0086R TGFβ1  转化生长因子β1抗体

hz-1838R TIEG1/KLF10  TGF-β诱导早期应答基因1抗体

hz-0100R TGF beta 2 Propeptide  转移生长因子β2抗体

hz-0099R TGF beta 3 propeptide  转移生长因子β3抗体

hz-0638R TGF Beta R1/TGFBR1  转移生长因子β受体1抗体（TGF-βRⅠ）

hz-0117R TGF beta R2/TGFBR2  转移生长因子β受体2抗体（TGF-βRⅡ）

hz-1910R TGF Beta R3  转移生长因子β受体3抗体（TGF-βRⅢ）

hz-1911R TGM3  转谷氨酰酶3抗体

hz-0632R Thioster-containing protein 1  按蚊硫酯包含蛋白-1抗体

hz-1276R ERdj5/DNAJC10  Erdj5/DNAJC10蛋白抗体

hz-1914R thrombin II  凝血酶Ⅱ(凝血因子II)抗体

hz-5476R phospho-MAPK14(Thr180)  磷酸化p38MAPK抗体

hz-1334R TIE1  血管生成素受体1抗体

hz-5477R phospho-MAPK14(Tyr323)  磷酸化p38MAPK抗体

hz-0778R Thy-1/CD90/ Thy1.1  CD90抗体

hz-4137R MAPKAPK5/PRAK  p38调节/激活蛋白激酶抗体

hz-5504R phospho-MAPKAPK5(Thr182)  磷酸化p38调节/激活蛋白激酶抗体

hz-5505R phospho-MAPKAPK5(Ser93)  磷酸化p38调节/激活蛋白激酶抗体

hz-2474R CD93/C1qrp  CD93抗体

hz-2521R CD94/KLRD1  NK细胞表面抑制性受体CD94抗体

hz-2522R CD97  CD97抗体

hz-2523R CD99/E2 antigen  CD99抗体

hz-0226R Thymosin Alpha-1/PTMA  胸腺肽α1抗体

hz-0706G T4/L-Thyroxine  甲状腺素T4抗体

hz-1300R TIE2/CD202b  血管生成素受体2抗体

hz-3448R Phospho-Tie2 (Ser1119)  磷酸化血管生成素受体2抗体

hz-3449R Phospho-Tie2 (Tyr992)  磷酸化血管生成素受体2抗体

hz-1916R RARRES1/TIG1  视黄酸受体应答蛋白1抗体

hz-1501R Chhzerin/TIG2  视黄酸受体应答蛋白2抗体

hz-1917R Rarres3/TIG3  视黄酸受体应答蛋白3抗体

hz-0640R TIGAR  TIGAR蛋白抗体

hz-0415R TIMP-1(NT)  金属蛋白酶组织抑制因子-1抗体（N端）

hz-0416R TIMP-2  金属蛋白酶组织抑制因子-2抗体

hz-0417R TIMP-3  金属蛋白酶组织抑制因子-3抗体

hz-0418R TIMP-4  金属蛋白酶组织抑制因子-4抗体

hz-3583R TLK1  调节染色体组装激酶1抗体

hz-3424R Phospho-TLK1(Ser695)  磷酸化调节染色体组装激酶1抗体