范可尼综合征相关蛋白FAN1抗体

英文名称    FAN1    

中文名称    范可尼综合征相关蛋白FAN1抗体    

别    名    6030441H18Rik; Coiled coil domain containing protein MTMR15; DKFZp451H236; DKFZp686K16147; FAN1; FAN1_HUMAN; FANCD2/FANCI associated nuclease 1; FANCD2/FANCI-associated nuclease 1; Fanconi associated nuclease 1; Fanconi-associated nuclease 1; KIAA1018; MTMR 15; MTMR15; Myotubularin related protein 15; Myotubularin-related protein 15.    

说 明 书    0.1ml  0.2ml      

研究领域    细胞生物  神经生物学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep, GPV,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 范可尼综合征相关蛋白FAN1抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    114kDa    

细胞定位    细胞核     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human FAN1    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

范可尼综合征相关蛋白FAN1抗体产品介绍    background:

Nuclease required for maintenance of chromosomal stability. Plays a key role in DNA repair of DNA interstrand cross-links (ICL) by being recruited to sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, possibly in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Has both endonuclease activity toward 5'-flaps and 5'-exonuclease activity: may act in concert with the 3'-flap-specific enzymes to unhook the ICL by cleaving the lagging-strand template.

Function:
Nuclease required for maintenance of chromosomal stability. Plays a key role in DNA repair of DNA interstrand cross-links (ICL) by being recruited to sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, possibly in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Has both endonuclease activity toward 5'-flaps and 5'-exonuclease activity: may act in concert with the 3'-flap-specific enzymes to unhook the ICL by cleaving the lagging-strand template. 

Subunit:
Interacts with FANCD2 (when monoubiquitinated). Interacts with FANCI, MLH1, MLH3 and PMS2.

Subcellular Location:
Nucleus. Localizes at sites of DNA damage following recruitment by monoubiquitinated FANCD2.

DISEASE:
Defects in FAN1 are the cause of interstitial nephritis, karyomegalic (KMIN) [MIM:614817]. A rare kidney disease characterized by chronic tubulointerstitial nephritis associated with massively enlarged tubular epithelial cell nuclei. The clinical picture is associated with recurrent upper respiratory tract infections in addition to chronic kidney disease beginning in the third decade of life.

Similarity:
Belongs to the FAN1 family.
Contains 1 UBZ-type zinc finger.
Contains 1 VRR-NUC domain.

Database links:
UniProtKB/Swiss-Prot: Q9Y2M0.4

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

范可尼综合征相关蛋白FAN1抗体

hz-1651R phospho-PAK1+PAK2+PAK3 (Ser141)  磷酸化p21激活激酶1/2/3抗体

hz-3315R Phospho-PAK1 (Ser199/204)/PAK2 (Ser192/197)  磷酸化p21激活激酶1/2抗体

hz-3316R Phospho-PAK1(Thr423)/PAK2 (Thr402)  磷酸化p21激活激酶1/2抗体

hz-1653R phospho-PAK1(Ser144)  磷酸化p21激活激酶1抗体

hz-1654R phospho-PAK2(Ser141)  磷酸化p21激活激酶2抗体

hz-3317R Phospho-PAK2 (Ser20)  磷酸化p21激活激酶2抗体

hz-1655R phospho-PAK3(Ser139)  磷酸化p21激活激酶3抗体

hz-1652R phospho-PAK1/2/3(Thr423)  磷酸化p21激活激酶1/2/3抗体

hz-0655R PAK7/PAK5/MBT  激活激酶PAK7抗体

hz-5542R phospho-PAK1(Thr212)  磷酸化p21激活激酶1抗体

hz-0773R FAM3A  胰腺衍生因子抗体

hz-4153R PAK6  P21蛋白激活的蛋白激酶6抗体

hz-5556R phospho-PAK6(Ser165)  磷酸化P21蛋白激活的蛋白激酶6

hz-0739R PAP2c/AP2-gamma  磷脂酸磷酸酶2C抗体

hz-3928R PAPK/ALS2CR2  肌萎缩侧索硬化症相关蛋白2（2号染色体）抗体

hz-5423R PPAP2A  磷酸脂磷酸水解酶1抗体

hz-5433R PPAP2C  磷酸脂磷酸水解酶2抗体

hz-4127R PAP2B  磷脂酸磷酸酶2b抗体

hz-0828R PAR-1/Thrombin receptor  蛋白酶激活受体-1抗体

hz-1178R PAR-2  蛋白酶激活受体-2抗体

hz-1196R PAR4  蛋白酶活化受体4抗体

hz-3325R Phospho-PAR4 (Thr163)  磷酸化蛋白酶活化受体4抗体

hz-1865R Parkin protein/PARK2  帕金蛋白抗体

hz-5552R phospho-PARK2(Ser101)  磷酸化帕金蛋白抗体

hz-5553R phospho-PARK2(Ser378)  磷酸化帕金蛋白抗体

hz-0769R PARP  多腺苷二磷酸多聚酶抗体/多聚ADP-核糖聚合酶1

hz-2138R PARP (N-Terminus)  多腺苷二磷酸多聚酶抗体(N端)

hz-1199R PAX1  配对盒基因1抗体

hz-1187R PAX2  配对盒基因2抗体

hz-1097R PAX3  配对盒基因3抗体

hz-1861R PAX5  配对盒基因5抗体

hz-2413R PAX7  配对盒基因7抗体

hz-1201R PAX8  配对盒基因8抗体

hz-1102R PAX9  配对盒基因9抗体