英文名称 FACL4
中文名称 酰基辅酶A合成酶4抗体
别 名 ACS 4; ACS4; ACSL 4; Acsl4; ACSL4_HUMAN; acyl CoA synthetase 4; Acyl CoA synthetase long chain family member 4; FACL 4; FACL4; Fatty acid Coenzyme A ligase; fatty acid Coenzyme A ligase long-chain 4; LACS 4; LACS4; Lignoceroyl CoA synthase; Long chain 4; long chain acyl CoA synthetase 4; long chain fatty acid CoA ligase 4; long chain fatty acid Coenzyme A ligase 4; Long-chain acyl-CoA synthetase 4; Long-chain-fatty-acid--CoA ligase 4; MRX63; MRX68.
说 明 书 0.1ml 0.2ml
研究领域 细胞生物 发育生物学 神经生物学 信号转导 新陈代谢
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep,
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 酰基辅酶A合成酶4抗体(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 79kDa
细胞定位 细胞浆 细胞膜
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human FACL4/ACSL4
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
酰基辅酶A合成酶4抗体产品介绍 background:
Acyl-CoA synthetases, also known as long-chain fatty-acid CoA synthases (FACL) or palmitoyl-CoA ligases, include ACSL1-6, which are all single-pass membrane proteins localizing to the mitochondrion, microsome or peroxisome. FACL proteins are important for synthesis of cellular lipids and for ∫-oxidation degradation. Specifically, ACSL proteins catalyze the activation of long-chain fatty acids to acyl-CoAs, which can be metabolized to form CO2, triacylglycerol (TAG), phospholipids (PL) and cholesteryl esters (CE). ACSL3 preferentially utilizes laurate, myristate, arachidonate and eicosapentaenoate among saturated and unsaturated long chain fatty acids. FACL3 is expressed as two isoforms in various tissues, including brain, heart, placenta, prostate, skeletal muscle, testis and thymus. FACL4 preferentially utilizes arachidonate and is abundant in steroidogenic tissues. FACL4 may modulate female fertility and uterine prostaglandin production.
Function:
Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates.
Subcellular Location:
Mitochondrion outer membrane. Peroxisome membrane. Microsome membrane. Endoplasmic reticulum membrane.
DISEASE:
Defects in ACSL4 are the cause of mental retardation X-linked type 63 (MRX63) [MIM:300387]. Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.
Defects in ACSL4 are involved in Alport syndrome with mental retardation midface hypoplasia and elliptocytosis (ATS-MR) [MIM:300194]. A X-linked contiguous gene deletion syndrome characterized by glomerulonephritis, deafness, mental retardation, midface hypoplasia and elliptocytosis.
Similarity:
Belongs to the ATP-dependent AMP-binding enzyme family.
Database links:
Entrez Gene: 2182 Human
Entrez Gene: 50790 Mouse
Entrez Gene: 113976 Rat
Omim: 300157 Human
SwissProt: O60488 Human
SwissProt: Q9QUJ7 Mouse
SwissProt: O35547 Rat
Unigene: 268785 Human
Unigene: 391337 Mouse
Unigene: 87821 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
酰基辅酶A合成酶4抗体
hz-3304R Phospho-NMDAR2A/NR2A (Tyr1246) 磷酸化谷氨酸受体2A抗体
hz-3305R Phospho-NMDAR2A (Tyr1325) 磷酸化谷氨酸受体2A抗体
hz-0222R NR2B/NMDAR2B 谷氨酸受体2B抗体
hz-3306R Phospho-NMDAR2B (Tyr1070) 磷酸化谷氨酸受体2B抗体
hz-3307R NMDAR2B 谷氨酸受体2B抗体
hz-5380R Phospho-NMDAR2B (Tyr1252) 磷酸化谷氨酸受体2B抗体
hz-5381R Phospho-NMDAR2B (Tyr1336) 磷酸化谷氨酸受体2B抗体
hz-5382R Phospho-NMDAR2B (Ser1480) 磷酸化谷氨酸受体2B抗体
hz-5383R Phospho-NMDAR2B (Ser1303) 磷酸化谷氨酸受体2B抗体
hz-1067R NR2C/NMDAR2C 谷氨酸受体2C抗体
hz-1072R NR2D/NMDAR2D 谷氨酸受体2D抗体
hz-1146R NRAS 原癌基因N-Ras抗体
hz-3563R NR1D1/REV-ERB alpha 细胞核受体Rev-Erbα抗体
hz-3386R Phospho-NR1D1(Ser55/59) 磷酸化细胞核受体Rev-Erbα抗体
hz-1074R Nrf2 核因子2相关因子2抗体
hz-2013R phospho-Nrf2 (Ser40) 磷酸化核因子2相关因子2(Ser40)抗体
hz-1342R NRF-1 核呼吸因子-1抗体
hz-2568R CD303/BDCA-2 C型凝集素结构域家族4成员C抗体
hz-0693R NRP1/CD304 神经纤毛蛋白1抗体
hz-5519R phospho-NRP1(Thr916) 磷酸化神经纤毛蛋白1抗体
hz-0694R Neuropilin-2 神经纤毛蛋白-2抗体
hz-2590R NRSF/REST 神经元抑制蛋白抗体
hz-0700R NSBP1 核小体结合蛋白1抗体
hz-5088R NSDHL 类固醇脱氢酶样蛋白NSDHL抗体
hz-1027R NSE/ENO2/γ Enolase 神经元特异性烯醇化酶抗体
hz-0160R NT-3 proprotein 神经营养因子-3前蛋白抗体
hz-0158R NT-4/NT-5 神经生长因子4/5抗体
hz-3685R MT-ND1 NADH复合体1抗体
hz-3952R MT-ND5 NADH复合体5抗体
hz-3955R MT-ND6 NADH复合体6抗体
hz-1958R NTCP/SLC10A1 钠离子/牛磺胆酸共转运蛋白
hz-4189R ASBT/SLC10A2 顶膜钠依赖性胆盐转运体蛋白抗体
hz-0073R Neurturin 神经生长因子抗体
企业名称
上海沪震生物科技有限公司
企业信息已认证
企业类型
信用代码
310112001371133
成立日期
2014-05-08
注册资本
1000
经营范围
上海沪震生物科技有限公司
公司地址
上海市杨浦区密云路1018号复旦科技园808室
客服电话