缺氧诱导因子1α抑制蛋白/HIF1AN抗体

英文名称    FIH1/HIF1AN    

中文名称    缺氧诱导因子1α抑制蛋白/HIF1AN抗体    

别    名    Hypoxia inducible factor asparagine hydroxylase; Factor inhibiting HIF1; FIH 1; FIH-1; FIH1; Hypoxia inducible factor 1 alpha inhibitor; Hypoxia inducible factor 1 alpha subunit inhibitor; Peptide aspartate beta dioxygenase; HIF1AN; DKFZp762F1811; FIH1; HIF1AN; FLJ20615; FLJ22027; HIF1N_HUMAN.    

说 明 书    0.2ml      

研究领域    肿瘤  心血管  细胞生物  免疫学  染色质和核信号  神经生物学  信号转导      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Dog, Pig, Cow,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 缺氧诱导因子1α抑制蛋白/HIF1AN抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    38kDa    

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human FIH1/HIF1AN    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

缺氧诱导因子1α抑制蛋白/HIF1AN抗体产品介绍    background:

HIF1AN (Hypoxia inducible factor 1 alpha inhibitor) is a corepressor that interacts with hypoxia inducible factor 1 (HIF1) alpha and the von Hippel Lindau tumor suppressor protein to mediate repression of HIF1 transcriptional activity.

Function:
Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminaltransactivation domain (CAD). Functions as an oxygen sensor and,under normoxic conditions, the hydroxylation prevents interactionof HIF-1 with transcriptional coactivators includingCbp/p300-interacting transactivator. Involved in transcriptionalrepression through interaction with HIF1A, VHL and histonedeacetylases. Hydroxylates specific Asn residues within ankyrinrepeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A andseveral other ARD-containing proteins. Also hydroxylates Asp andHis residues within ARDs of ANK1 and TNKS2, respectively.Negatively regulates NOTCH1 activity, accelerating myogenicdifferentiation. Positively regulates ASB4 activity, promotingvascular differentiation.

Subunit:
Homodimer; homodimerization is essential for catalyticactivity. Interacts with VHL and HIF1A. Part of a complex with VHL,HIF1A and HDAC1 or HDAC2 or HDAC3. Interacts with NFKB1 and NFKBIA.Interacts with NOTCH1, NOTCH2 and NOTCH3 but not with NOTCH4.Interacts with APBA3; binding inhibits HIF1AN binding to HIF1A.Interacts with TNKS2. Interacts with PPP1R12A. Interacts with ASB4(By similarity). Interacts with UBE3A.

Subcellular Location:
Nucleus. Cytoplasm. Cytoplasm, perinuclearregion. Note=Mainly cytoplasmic localization, but interaction withNOTCH1 results in nuclear localization and interaction with ABPA3results in perinuclear localization in macrophages.

Similarity:
Contains 1 JmjC domain.    

缺氧诱导因子1α抑制蛋白/HIF1AN抗体

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hz-1964 DDC(Human dopamine decarboxylase) ELISA Kit  人多巴胺脱羧酶

hz-1965 NNE(Human non-neuronal enolase) ELISA Kit  人非神经元性烯醇化酶

hz-1966 DBH(Human dopamine- Beta-hydroxylase) ELISA Kit  人多巴胺-β羟化酶

hz-1967 CHAc(Human choline acetylase) ELISA Kit  人胆碱乙酰化酶

hz-1968 ICD(Human isocitrate dhzydrogenase) ELISA Kit  人异柠檬酸脱氢酶

hz-1969 Try- II (Human Trypsinogen-2) ELISA Kit  人胰蛋白酶原Ⅱ

hz-1970 ADA(Human adenosine deaminase) ELISA Kit  人腺苷脱氨酶

hz-1971 HAase(Human Hyaluronidase) ELISA Kit  人透明质酸酶

hz-1972 AST(Human Aspartate aminotransferase) ELISA Kit  人天门冬氨酸氨基转移酶

hz-1973 ACP(Human Acid Phosphatase) ELISA Kit  人酸性磷酸酶

hz-1974 GPI(Human glucose-6-phosphate isomerase) ELISA Kit  人葡萄糖6磷酸异构酶

hz-1975 PGM(Human Phosphoglucomutase) ELISA Kit  人磷酸葡萄糖变位酶

hz-1976 LAP(Human Leucine aminopepridase) ELISA Kit  人亮氨酰氨基肽酶

hz-1977 SK(Human Streptokinase) ELISA Kit  人链激酶

hz-1978 RNASE(Human Ribonuclease) ELISA Kit  人核糖核酸酶

hz-1979 LPO(Human lipid peroxlde) ELISA Kit  人过氧化脂质/乳过氧化物酶

hz-1980 ASA(Human aryl sulfatase A) ELISA Kit  人芳基硫酸酯酶A

hz-1981 PON(Human paraoxonase) ELISA Kit  人对氧磷酶

hz-1982 PK(Human pyruvate kinase) ELISA Kit  人丙酮酸激酶

hz-1983 Gal-6S(Human galactose-6-sulphate sulphatase) ELISA Kit  人半乳糖6硫酸酯酶

hz-1984 IDS(Human iduronate sulfatase) ELISA Kit  人艾杜糖硫酸酯酶

hz-1985 BetaGD(Human Beta-glucuronidase) ELISA Kit  人β葡萄糖醛酸苷酶

hz-1986 Human Beta-glucosidase ELISA Kit  人β葡糖苷酶

hz-1987 Human Beta-lactamase ELISA Kit  人β内酰胺酶

hz-1988 Beta Manase(Human Alpha mannosidase) ELISA Kit  人β甘露糖苷酶