磷酸化纤维束蛋白同源物1抗体

英文名称    phospho-FSCN1(Ser39)    

中文名称    磷酸化纤维束蛋白同源物1抗体    

别    名    Fascin (phospho S39); Fascin (phospho S39); 55 kDa actin bundling protein; Actin bundling protein; FAN 1; FAN1; Fascin 1; Fascin homolog 1 actin bundling protein (Strongylocentrotus purpuratus); Fascin homolog 1; Fascin1; FLJ38511; FSCN 1; FSCN1; HSN; p55; Singed (Drosophila) like (sea urchin fascin homolog like); Singed drosophila homolog like; Singed like (fascin homolog sea urchin) (Drosophila); Singed like protein; SNL; Strongylocentrotus purpuratus.    

说 明 书    0.1ml      

产品类型    磷酸化抗体     

研究领域    细胞生物  信号转导  结合蛋白      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 磷酸化纤维束蛋白同源物1抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    55kDa    

细胞定位    细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated Synthesised phosphopeptide derived from human FSCN1 around the phosphorylation site of Ser39    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

磷酸化纤维束蛋白同源物1抗体产品介绍    background:

Human fascin is a highly conserved actin-bundling protein. Fascin, encoded by the human homolog for sn (hsn) gene, has been localized to microspikes and stress fibers of cultured cells where it is thought to be involved in the formation of microfilament bundles. It is expressed predominantly in dendritic cells. Lymphoid cells, myeloid cells and plasma cells are negative. However, Reed Sternberg cells in Hodgkin’s lymphoma are positive for fascin staining. Epstein-Barr virus may induce expression of fascin in B cells. 

Function:
Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration.

Subcellular Location:
Cytoplasm > cytoskeleton. Cell projection > filopodium. Cell projection > invadopodium.

Tissue Specificity:
Ubiquitous.

Post-translational modifications:
Phosphorylation on Ser-39 inhibits the actin-binding ability of fascin.

Similarity:
Belongs to the fascin family.

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.     

磷酸化纤维束蛋白同源物1抗体

hz-0742P p27 (cyclin-dependent kinase inhibitor 1B)  p27(抗原)

hz-0723P P63 protein  P63 肿瘤抑制基因（抗原）

hz-0431P OPG(Osteoprotegerin)  护骨素(多肽抗原)

hz-0747P OPGL (Osteoprotegerin ligand)  骨保护蛋白配体(抗原)

hz-0427P P311 protein  增生性瘢痕相关蛋白（抗原）

hz-0769P PARP(poly ADP-ribose polymerase)  多腺苷二磷酸多聚酶抗原

hz-0270P Visfatin-1 (PBEF1)(NT) Human  内脂素/内脏脂肪素（人：N端多肽）、内脏脂肪素、 又称：前B细胞克隆增强因子、内肥素、腹脂素

hz-0272P Visfatin-1 (PBEF1)(NT)   内脂素/内脏脂肪素

hz-0273P PBEF (CT)  内脂素/B细胞克隆增强因子

hz-0731P PEDF (pigment epithelium-derived factor)  色素上皮源性因子(多肽抗原）

hz-0739P PAP2c (Phosphatidic acid phosphatase 2c)  磷脂酸磷酸酶2C（抗原）

hz-0689P PEPT1 (Peptide-transporters 1)  肠道肽转运蛋白(小肽转运蛋白)多肽

hz-0748P PTEN/MMAC1  一种肿瘤抑制基因抗原

hz-0420P PIBF(progesterone induced blocking factor)  孕激素诱导阻断因子(抗原)

hz-0665P PIWIL1(piwi-like 1)  piwi 样1蛋白(抗原)

hz-0530P PPAR Gamma (peroxisome proliferator-activated receptor-gamma)  过氧化酶活化增生受体γ（抗原）

hz-0490P PP2Ac  蛋白磷酸酶4(抗原)

hz-0378P Runx3  一种新发现的抑癌基因(抗原)

hz-0278P RRAD (Ras-related associated with diabetes )  RRAD(多肽抗原)

hz-0783P SDF-1/CXCL12 (stromal cell derived factor-1)  基质细胞衍生因子-1(抗原)

hz-0211P shank1(SH3 and multiple anleyrin repead domins protein 1)  shank1多肽抗原

hz-0444P slc22A17 (solute carrier famili 22)  溶质转运蛋白家族22成员17(多肽抗原)

hz-0496P SLC24A5 (solute carrier family 24, mhzber 5)  可溶性载质转运蛋白SLC24A5（抗原）

hz-0473P solute carrier family 1  溶质携带物家族-1(抗原)

hz-0478P SLC6A4 (solute carrier family 6)  钾依赖钠钙交换蛋白6(抗原)

hz-0615P Survivin  细胞凋亡抑制因子的一种（抗原）

hz-0726P BIRC5/Survivin variant  细胞凋亡抑制因子4（抗原）

hz-0635P SSA/RO (ribonucleoprotein complex,RNP)  核糖核蛋白抗原RO/SSA(抗原)

hz-0276P SSB/La  干燥症SSB/La蛋白

hz-0718P Smad2(Mothers against decapentaplegic homolog 2)  Smad 2(抗原)

hz-0717P SPAG5/map126   精子相关抗原5(多肽抗原)

hz-0770P SP-A (pulmonary surfactant-associated glycoprotein A)  肺表面活性蛋白A(抗原)

hz-0679P SYVN1(synovial apoptosis inhibitor 1)  滑膜细胞凋亡抑制物1（抗体）

hz-0685P SYK (Spleen tyrosine kinase)  非受体型酪氨酸激酶(抗原)