少汗型外胚层发育不良相关蛋白EDAD抗体

英文名称    EDARADD    

中文名称    少汗型外胚层发育不良相关蛋白EDAD抗体    

别    名    Cr; Crinkled homolog; ectodysplasia A receptor associated death domain; Ectodysplasin-A receptor-associated adapter protein; ED3; EDA3; EDAD_HUMAN; EDAR associated death domain; EDAR-associated death domain protein; EDARADD; Protein crinkled homolog.    

说 明 书    0.1ml  0.2ml      

研究领域    发育生物学  信号转导  表观遗传学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 少汗型外胚层发育不良相关蛋白EDAD抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    25kDa    

细胞定位    细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human EDARADD    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

少汗型外胚层发育不良相关蛋白EDAD抗体产品介绍    background:

This gene was identified by its association with ectodermal dysplasia, a genetic disorder characterized by defective development of hair, teeth, and eccrine sweat glands. The protein encoded by this gene is a death domain-containing protein, and is found to interact with EDAR, a death domain receptor known to be required for the development of hair, teeth and other ectodermal derivatives. This protein and EDAR are coexpressed in epithelial cells during the formation of hair follicles and teeth. Through its interaction with EDAR, this protein acts as an adaptor, and links the receptor to downstream signaling pathways. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Function:
Adapter protein that interacts with EDAR DEATH domain and couples the receptor to EDA signaling pathway during morphogenesis of ectodermal organs. Mediates the activation of NF-kappa-B.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Detected in adult pancreas, placenta and fetal skin, and at lower levels in lung, thymus, prostate and testis.

DISEASE:
Defects in EDARADD are a cause of ectodermal dysplasia anhidrotic (EDA) [MIM:224900]; also known ectodermal dysplasia hypohidrotic autosomal recessive (HED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDA is characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands.

Similarity:
Contains 1 death domain.

Gene ID:
128178    

少汗型外胚层发育不良相关蛋白EDAD抗体

A-13-1 ADV IgM VII  腺病毒 IgM Ⅶ型(间接法二步法)

A-14-1 ADV IgM XI  腺病毒 IgM Ⅺ型(间接法二步法)

EA-1013 Hpt/HP (Rabbit Haptoglobin) ELISA Kit  兔结合珠蛋白/触珠蛋白

hz-1013 Mouse carcinohzbryonic antign,CEA ELISA Kit   小鼠癌胚抗原

hz-1013 IFN- Omega (Human Interferon Omega ,IFN- Omega ) ELISA Kit  人ω干扰素

EF-1013 IL-1 Alpha ELISA kit  鱼类白介素1α

hz-1013 MT/MLT (Rat Melatonin,MT/MLT) ELISA Kit  大鼠褪黑素

A-59-1 ADV IgG XI  腺病毒 IgG Ⅺ型(间接法二步法)

A-60-1 ADV IgG  腺病毒 IgG 混合型(间接法二步法)

A-20-1 ADV IgM  腺病毒 IgM 混合型(间接法二步法)

A-61-1 EB-VCA IgG  EB 病毒 IgG(间接法二步法)

A-17-1 EB-VCA IgM  EB 病毒 IgM(间接法二步法)

A-62-1 MP IgG  肺炎支原体 IgG(间接法二步法)

A-22-1 MP IgM  肺炎支原体 IgM(间接法二步法)

A-63-1 IFV IgG/IFV-A IgG   流感病毒A IgG(间接法二步法) ELISA试剂盒

A-24-1 IFV IgM/IFV-A IgM  流感病毒A IgM(间接法二步法)ELISA试剂盒

A-64-1 PIV IgG  付流感病毒 IgG(间接法二步法)

A-25-1 PIV IgM  付流感病毒 IgM(间接法二步法)

A-65-1 hzF IgG  流行性出血热病毒 IgG(间接法二步法)

A-31-1 hzF IgM  流行性出血热病毒 IgM(间接法二步法)

A-66-1 MU IgG  流行性腮腺炎病毒 IgG(间接法二步法)

A-67-1 MU IgM  流行性腮腺炎病毒 IgM(间接法二步法)

A-68-1 EPBV IgG  乙型脑炎病毒 IgG(间接法二步法)

A-69-1 EPBV IgM  乙型脑炎病毒 IgM(间接法二步法)

E-79-48/96 Beta-HCG  人绒毛膜促性腺激素(夹心法一/二步法)

EF-1014 IL-1 Beta ELISA Kit  鱼类白介素1β

EA-1014 Plg (Rabbit Plasminogen) ELISA Kit  兔子纤溶酶原

hz-1014 Mouse Cluster of differentiation 19,CD19 ELISA Kit  小鼠CD19分子

hz-1014 GlyCAM-1(Human glycosylation-dependent cell adhesion molecule-1) ELISA Kit  人糖基化依赖的细胞黏附分子

hz-1014 FGF-10(Rat fibroblast growth factor-10,FGF-10 )ELISA Kit  大鼠成纤维细胞生长因子10

E-84-48/96 Alb  白蛋白(夹心法一步法)

E-01-48/96 HAV IgM  抗－HAV IgM(夹心法 一步法)