红细胞膜蛋白4.2抗体

英文名称    protein 4.2    

中文名称    红细胞膜蛋白4.2抗体    

别    名    protein 4.2; protein4.2; EPB42; EPB42_HUMAN; Erythrocyte membrane protein band 4.2; Erythrocyte protein 4.2; Erythrocyte surface protein band 4.2; MGC116735; P4.2; PA; SPH5.    

说 明 书    0.2ml      

研究领域    心血管  细胞表面分子      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Horse, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 红细胞膜蛋白4.2抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    77kDa    

细胞定位    细胞浆 细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human EPB42/protein 4.2    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

红细胞膜蛋白4.2抗体产品介绍    background:

protein 4.2; protein4.2; EPB42; EPB42_HUMAN; Erythrocyte membrane protein band 4.2; Erythrocyte protein 4.2; Erythrocyte surface protein band 4.2; MGC116735; P4.2; PA; SPH5.

Function:
Probably plays an important role in the regulation of erythrocyte shape and mechanical properties. 

Subunit:
Oligomer. Interacts with the cytoplasmic domain of SLC4A1/band 3 anion transport protein.

Subcellular Location:
Cell membrane. Cytoplasm > cytoskeleton. Cytoplasmic surface of erythrocyte membranes.

Post-translational modifications:
Both cAMP-dependent kinase (CAPK) and another kinase present in the red-blood cells seem to be able to phosphorylate EPB42. 

DISEASE:
Defects in EPB42 are the cause of spherocytosis type 5 (SPH5) [MIM:612690]; also known as hereditary spherocytosis type 5 (HS5). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. Absence of band 4.2 associated with spur or target erythrocytes has also been reported. 

Similarity:
Belongs to the transglutaminase superfamily. Transglutaminase family. 

Database links:

Entrez Gene: 2038 Human

Omim: 177070 Human

SwissProt: P16452 Human

Unigene: 368642 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

Involvement in disease:Defects in EPB42 are the cause of spherocytosis type 5 (SPH5); also known as hereditary spherocytosis type 5 (HS5). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. Absence of band 4.2 associated with spur or target erythrocytes has also been reported.    

红细胞膜蛋白4.2抗体

hz-0749R Kiss 1/Kisspeptin  肿瘤转移抑制基因抗体

hz-1064R KLF4  肠道内富含的Kruppel样因子/上皮锌指蛋白4抗体

hz-2385R KLF5/UKHC  驱动蛋白KIF5B抗体

hz-2303R phospho-KLF5(Ser311)  磷酸化肠道内富含的Kruppel样因子5抗体

hz-2019R phospho-KLF5(Ser272)  磷酸化KLF5抗体

hz-2020R phospho-KLF5(Ser275)  磷酸化KLF5抗体

hz-2772R KLF2  肺Kruppel样因子抗体

hz-1395R KLF6/PAC1  转染抑癌基因KLF6抗体

hz-3649R KLF8/KLF3  KLF样转录因子8抗体

hz-3644R KLF9/BTEB1  转录因子KLF9抗体

hz-1577R KLF13/RFLAT-1  肠道内富含的Kruppel样因子13

hz-0225R KLH  血蓝蛋白抗体

hz-0225M KLH  血蓝蛋白抗体

hz-1963R KLK1  激肽释放酶1抗体

hz-5868R KLK2  激肽释放酶2抗体

hz-1094R kappa Opioid receptor  kappa型阿片受体抗体

hz-3623R mu Opioid receptor  μ-型阿片受体抗体

hz-3724R Phospho-mu Opioid Receptor (Ser375)  磷酸化μ-型阿片受体抗体

hz-3624R Delta Opioid Receptor  D型阿片受体抗体

hz-3712R Phospho-delta Opioid Receptor (Ser363)  磷酸化D型阿片受体抗体

hz-3800R Kappa Light Chain  k轻链抗体

hz-1964R KLK3/Prostate Specific Antigen  激肽释放酶3/舒血管素3抗体

hz-1965R KLK4  激肽释放酶4抗体

hz-5869R KLK5  激肽释放酶5抗体

hz-5870R KLK6  激肽释放酶6抗体

hz-1966R KLK7  激肽释放酶7抗体

hz-5871R KLK8  激肽释放酶8抗体

hz-1967R KLK9  激肽释放酶9抗体（舒血管素9）

hz-2531R KLK10  激肽释放酶10抗体

hz-3799R KLK11  激肽释放酶11抗体

hz-5865R KLK12  激肽释放酶12抗体

hz-5866R KLK13  激肽释放酶13抗体

hz-1968R KLK14  激肽释放酶14抗体

hz-5867R KLK15  激肽释放酶15抗体