原发性纤毛运动障碍相关蛋白DPCD抗体

英文名称    DPCD    

中文名称    原发性纤毛运动障碍相关蛋白DPCD抗体    

别    名    Deleted in a mouse model of primary ciliary dyskinesia; DKFZp566F084; dpcd; DPCD protein; DPCD_HUMAN; OTTHUMP00000020329; Protein DPCD; RP11 529I10.4; RP11-529I10.4.    

说 明 书    0.1ml  0.2ml      

研究领域    心血管  细胞生物  细胞分化      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 原发性纤毛运动障碍相关蛋白DPCD抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    23kDa    

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human DPCD    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

原发性纤毛运动障碍相关蛋白DPCD抗体产品介绍    background:

DPCD is a 203 amino acid protein that is expressed at higher levels during ciliated cell differentiation, suggesting that DPCD plays a role in the function or formation of ciliated cells. In primary ciliary dyskinesia (PCD), an autosomal recessive disease that is caused by mutations affecting the proper function of cilia, an exon in the DPCD gene is deleted. The phenotype of PCD is variable, though it may include symptoms such as sinus inverse totalis, infertility or otitis media. In severe cases, patients develop end-stage bronchiectasis and require a lung transplantation. DPCD is highly expressed in testis, with weak expression in heart, pancreas and skeletal muscle.

Function:
May play a role in the formation or function of ciliated cells.

Tissue Specificity:
Highly expressed in the testis. Weakly expressed in pancreas, skeletal muscle and heart. Expression increases during ciliated cell differentiation.

Similarity:
Belongs to the DPCD family.

Gene ID:
25911

Database links:

Entrez Gene: 25911 Human

Entrez Gene: 516908 Cow

Entrez Gene: 477800 Dog

Entrez Gene: 226162 Mouse

Entrez Gene: 294004 Rat

SwissProt: Q24K21 Cow

SwissProt: Q9BVM2 Human

SwissProt: Q8BPA8 Mouse

SwissProt: Q6AYM4 Rat

Unigene: 658128 Human

Unigene: 21978 Mouse

Unigene: 50057 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

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