对接蛋白4抗体

英文名称    DOK4    

中文名称    对接蛋白4抗体    

别    名    docking protein 4; Downstream of tyrosine kinase 4; FLJ10488; DOK4_HUMAN.    

说 明 书    0.2ml      

研究领域    神经生物学  信号转导  激酶和磷酸酶      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 对接蛋白4抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    37kDa    

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human DOK4    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

对接蛋白4抗体产品介绍    background:

The downstream of kinase family (Dok-1-7) are members of a class of docking proteins that interact with receptor tyrosine kinases and, via this interaction, mediate biological responses within the body. Dok-4 (Downstream of kinase-4) is a 326 amino acid protein that contains one PH domain and one IRS-type PTB domain and belongs to the Dok family of interacting proteins. Expressed in a variety of tissues with highest expression in liver, heart, kidney and skeletal muscle, Dok-4 plays an important role in Ret-mediated neurite outgrowth and may link Ret with downstream effectors during neuronal differentiation. Additionally, Dok-4 is thought to play a positive role in the activation of MAPK pathways and may participate in T-cell induced immune system regulation. Overexpression of Dok-4 is associated with clear cell renal cell carcinoma, suggesting a role for Dok-4 in tumorigenesis.

Function:
DOK4 (docking protein 4) belongs to the family of docking proteins which interact with receptor tyrosine kinases and mediate particular biological responses. DOK4 functions in RET mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. 

Subunit:
Interacts with RET and TEK/TIE2. Interaction with RET is mediated through the PTB domain and requires phosphorylation of RET 'Tyr-1062' (By similarity). 

Tissue Specificity:
Widely expressed. High expression in skeletal muscle, heart, kidney and liver. Weaker expression in spleen, lung and small intestine, brain, heart and. Expressed in both resting and activated peripheral blood T-cells. 

Post-translational modifications:
Phosphorylated on tyrosine residues in response to insulin, IGF1 or RET stimulation. 

Similarity:
Belongs to the DOK family. Type B subfamily. 
Contains 1 IRS-type PTB domain. 
Contains 1 PH domain.     

对接蛋白4抗体

hz-0269P FoxP3  叉头蛋白3-T细胞转录因子（多肽抗原）

hz-0325P GAD-65 (glutamate decarboxylase)  谷氨酸脱羧酶-65(抗原)

hz-0154P GAP-43 ( Growth associated protein-43 )  生长相关蛋白-43（抗原）

hz-0010P Gastrin  胃泌素（抗原）

hz-0840P AMACR/P504S(alpha-methylacyl-CoA rachzase)  α－甲基酰基辅酶A消旋酶抗原

hz-0199P GFAP(Glial Fibrillary Acidic Protein)  胶质纤维酸性蛋白（抗原）

hz-1116P AMPK Beta1 (AMP-activated Protein Kinase beta-1)  腺苷单磷酸活化蛋白激酶β1抗原

hz-0424P MMP-1  基质金属蛋白酶-1

hz-0412P MMP-2  基质金属蛋白酶-2(多肽抗原)

hz-2199P beta-Amyloid(1-16) peptide (rat, mouse)   β淀粉样肽（1-16）（大鼠，小鼠）

hz-0413P MMP-3(matrix metalloproteinase-3/Transin-1/SL-1/Stromelysin-1 precursor)  基质金属蛋白酶-3(抗原)

hz-0423P MMP-7(Matrilysin/matrix metalloproteinases-7)  基质金属蛋白酶-7(抗原)

hz-0414P MMP-14(Matrix metalloproteinase-14)  金属基质蛋白酶-14

hz-0201P GFRAlpha-1(GDNF family receptor alpha-1)  GDNF家族受体α-1（抗原）

hz-0587P Ang- II (Angiotensin II )  血管紧张素II抗原

hz-0351P GLUT2(Glucose transporter type 2)  葡萄糖转运蛋白2（抗原）

hz-2040P ANP(atrial natriuretic peptide)  心钠肽（心钠素）抗原

hz-0168P GFRA4 ( Persephin receptor ) (GFR receptor alpha 4)  GDNF家族受体α-4（抗原）

hz-0205P GHRF (GHRH)  生长激素释放激素（因子）（抗原）

hz-0800P ANGPTL1/ANG-1 (Angiopoietin-like Protein 1)  血管位蛋白样1/血管生成素样蛋白-1抗原

hz-0384P GLUT4(Glucose transporter type 4)  葡萄糖转运蛋白4（抗原）

hz-0098P GIP (Gastric Inhibitory polypeptide)  胃泌素抑制肽（抗原）

hz-0537P ANGPTL2/ANG-2 (Angiopoietin-like Protein 2)  血管位蛋白样2/血管生成素样蛋白-2（多肽）

hz-0208P GLP-2(Glucagon-like peptide-2)  胰高血糖素样肽-2（多肽抗原）

hz-0194P GRP94 (gp96)  94kDa 糖调节蛋白（抗原）

hz-1171P Annexin A  膜粘连蛋白 A抗原

hz-0348P G Protein(Guanine nucleotide-binding regulatory protein)  G蛋白（鸟苷酸结合蛋白）（抗原）

hz-0252P GR (Glucocorticoid receptor)  糖皮质激素受体 多肽

hz-0576P Annexin II  膜粘连蛋白-2抗原

hz-0023P GSK-3 Beta(NT) (Glycogen Synthase Kinase-3 Beta)  糖原合酶激酶-3β（抗原）

hz-0341P CKR-L2( G protein-coupled receptor-2 )  G蛋白偶联受体-2(抗原)

hz-0028P GSK-3 Beta, (Glycogen Synthase Kinase-3)  葡萄糖合成激酶-3（抗原）

hz-0136P GTP-CH-1  三磷酸鸟苷环水解酶（抗原）