唐氏综合征细胞粘附分子抗体

英文名称    Dscam    

中文名称    唐氏综合征细胞粘附分子抗体    

别    名    CHD2 42; CHD2 52; CHD2; Down syndrome cell adhesion molecule; DSCAM; DSCAM_HUMAN; human CHD2-52 down syndrome cell adhesion molecule 2, 9; OTTHUMP00000109193 2; SD11109p.    

说 明 书    0.2ml      

研究领域    细胞生物  发育生物学  神经生物学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Sheep,     

产品应用    ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500 唐氏综合征细胞粘附分子抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    220kDa    

细胞定位    细胞膜 分泌型蛋白     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Dscam (301-400aa)    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

唐氏综合征细胞粘附分子抗体产品介绍    background:

DSCAM is a cell adhesion molecule belonging to the immunoglobulin superfamily. It is predominantly expressed in brain and contains six Fibronectin type-III domains and ten Ig-like C2-type domains. In mice, DSCAM is responsible for regulating isoneuronal self-avoidance, the tendency for sister arbors to avoid crossing each other and to spread out proportionately over an area. Isoneuronal self-avoidance is important for proper terminal branching (arborization). In some cell types, DSCAM also mediates heteroneuronal self-avoidance, which is important for the regular spacing of cell bodies and the prevention of hyperfasciculation. In humans, two DSCAM isoforms exist due to alternative splicing. The long isoform (also known as CHD2-42) is a single pass type I membrane protein, while the short isoform (CHD2-52), which lacks the C-terminal transmembrane containing region (amino acids 1572-2012), is secreted.

Function:
Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies. Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. In spinal chord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding. Enhances netrin-induced phosphorylation of PAK1 and FYN. Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38.

Subunit:
Interacts with DCC; the interaction is abolished in response to NTN1 (By similarity). Probably found in a ternary complex composed of DSCAM, PAK1 and RAC1. Interacts (via extracellular domain) with NTN1. Interacts (via cytoplasmic domain) with PAK1; the interaction is direct and enhanced in presence of RAC1. Interacts with RAC1; the interaction requires PAK1.

Subcellular Location:
Secreted and Cell membrane. Localized in the soma, cell membrane, axon and growth cone of dissociated commissural axons.

Tissue Specificity:
Primarily expressed in brain.

Post-translational modifications:
Phosphorylated at tyrosine residues. Phosphorylation is enhanced by netrin.

Similarity:
Contains 6 fibronectin type-III domains.
Contains 10 Ig-like C2-type (immunoglobulin-like) domains.    

唐氏综合征细胞粘附分子抗体

hz-0364R-RBIThz Rabbit Anti-human IgG F(ab')2/RBITC  罗丹明标记的兔抗人IgG F(ab')2 

hz-0364R-FIThz Rabbit Anti-human IgG F(ab')2/FITC  FITC标记的兔抗人IgG F(ab')2 

hz-0364R-Gold Rabbit Anti-human IgG F(ab')2/Gold  胶体金标记的兔抗人IgG F(ab')2 

hz-0364R-AP Rabbit Anti-human IgG F(ab')2/AP  碱性磷酸酶（AP）标记的兔抗人IgG F(ab')2 

hz-0364R-hzy3 Rabbit Anti-human IgG F(ab')2/Cy3  Cy3标记的兔抗人IgG F(ab')2 

hz-0364R-hzy5 Rabbit Anti-human IgG F(ab')2/Cy5  Cy5标记的兔抗人IgG F(ab')2 

hz-0364R-hzy5.5 Rabbit Anti-human IgG F(ab')2/Cy5.5  Cy5.5标记的兔抗人IgG F(ab')2 

hz-0364R-hzy7 Rabbit Anti-human IgG F(ab')2/Cy7  Cy7标记的兔抗人IgG F(ab')2 

hz-0364R-PE Rabbit Anti-human IgG F(ab')2/PE  PE标记的兔抗人IgG F(ab')2 

hz-0364R-PE-hzy3 Rabbit Anti-human IgG F(ab')2/PE-Cy3  PE-Cy3标记的兔抗人IgG F(ab')2 

hz-0364R-PE-hzY5 Rabbit Anti-human IgG F(ab')2/PE-CY5  PE-CY5标记的兔抗人IgG F(ab')2 

hz-0364R-APhz Rabbit Anti-human IgG F(ab')2/APC  APC标记的兔抗人IgG F(ab')2 

hz-0364R-AF350 Rabbit Anti-human IgG F(ab')2/Alexa Fluor 350  Alexa Fluor 350标记的兔抗人IgG F(ab')2 

hz-0364R-AF488 Rabbit Anti-human IgG F(ab')2/Alexa Fluor 488  Alexa Fluor 488标记的兔抗人IgG F(ab')2 

hz-0364R-AF555 Rabbit Anti-human IgG F(ab')2/Alexa Fluor 555  Alexa Fluor 555标记的兔抗人IgG F(ab')2 

hz-0364R-AF647 Rabbit Anti-human IgG F(ab')2/Alexa Fluor 647  Alexa Fluor 647标记的兔抗人IgG F(ab')2 

hz-0364R-PE-hzy5.5 Rabbit Anti-human IgG F(ab')2/PE-Cy5.5  PE-Cy5.5标记的兔抗人IgG F(ab')2 

hz-0364R-PE-hzy7 Rabbit Anti-human IgG F(ab')2/PE-Cy7  PE-Cy7标记的兔抗人IgG F(ab')2 

hz-0364R-Bio Rabbit Anti-human IgG F(ab')2/Bio  生物素标记的兔抗人IgG F(ab')2 

hz-0364R-HRP Rabbit Anti-human IgG F(ab')2/HRP  辣根过氧化物酶标记的兔抗人IgG F(ab')2 

hz-0377R-HRP Rabbit Anti-mouse IgG-Fc/HRP  辣根过氧化物酶标记的兔抗小鼠IgG-Fc

hz-0377R-PE-hzy3 Rabbit Anti-mouse IgG-Fc/PE-Cy3  PE-Cy3标记的兔抗小鼠IgG-Fc

hz-0377R-PE-hzY5 Rabbit Anti-mouse IgG-Fc/PE-CY5  PE-CY5标记的兔抗小鼠IgG-Fc

hz-0377R-APhz Rabbit Anti-mouse IgG-Fc/APC  APC标记的兔抗小鼠IgG-Fc

hz-0377R-AF350 Rabbit Anti-mouse IgG-Fc/Alexa Fluor 350  Alexa Fluor 350标记的兔抗小鼠IgG-Fc

hz-0377R-AF488 Rabbit Anti-mouse IgG-Fc/Alexa Fluor 488  Alexa Fluor 488标记的兔抗小鼠IgG-Fc

hz-0377R-AF555 Rabbit Anti-mouse IgG-Fc/Alexa Fluor 555  Alexa Fluor 555标记的兔抗小鼠IgG-Fc

hz-0377R-AF647 Rabbit Anti-mouse IgG-Fc/Alexa Fluor 647  Alexa Fluor 647标记的兔抗小鼠IgG-Fc

hz-0377R-PE-hzy5.5 Rabbit Anti-mouse IgG-Fc/PE-Cy5.5  PE-Cy5.5标记的兔抗小鼠IgG-Fc

hz-0377R-PE-hzy7 Rabbit Anti-mouse IgG-Fc/PE-Cy7  PE-Cy7标记的兔抗小鼠IgG-Fc

hz-0377R-AP Rabbit Anti-mouse IgG-Fc/AP  碱性磷酸酶（AP）标记的兔抗小鼠IgG-Fc