表皮乳头源性蛋白6抗体

英文名称    DERP6    

中文名称    表皮乳头源性蛋白6抗体    

别    名    MST071; MSTP071; chromosome 17 open reading frame 81; Dermal papilla derived protein 6; dermal papilla-derived protein 6; DERP6; HSPC002; S phase 2 protein; ELP5_HUMAN.    

说 明 书    0.2ml      

研究领域    肿瘤  细胞生物  表观遗传学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Pig, Cow, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 表皮乳头源性蛋白6抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    35kDa    

细胞定位    细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human DERP6/C17orf81    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

表皮乳头源性蛋白6抗体产品介绍    background:

DERP6, is a 316 amino acid protein that localizes to the cytoplasm and exists as multiple alternatively spliced isoforms. Expressed ubiquitously with highest expression in liver, heart, testis, brain and skeletal muscle, DERP6 is thought to be involved in p53-mediated transcriptional regulation. The gene encoding DERP6 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.

Function:
Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration (By similarity). May be involved in TP53-mediated transcriptional regulation. 

Subunit:
Component of the RNA polymerase II elongator complex (Elongator), which consists of IKBKAP/ELP1, STIP1/ELP2, ELP3, ELP4, ELP5 and ELP6; in the complex, is required for optimal binding of ELP3 to ELP4.

Subcellular Location:
Cytoplasmic.

Tissue Specificity:
cancers of the ovary, colon, prostate gland and fallopian tubes

Similarity:
Belongs to the ELP5 family.     

表皮乳头源性蛋白6抗体

hz-1185R TRAF3/CD40bp  肿瘤坏死因子受体相关蛋白3抗体

hz-5806R TRAF4/CART 1  肿瘤坏死因子受体相关蛋白4抗体

hz-1184R TRAF6  肿瘤坏死因子受体相关因子6抗体

hz-1214R TRAIL  肿瘤坏死因子相关凋亡诱导配体抗体

hz-0152R Transthyretin  转甲状腺素蛋白抗体

hz-4041R Transaldolase 1  转醛醇酶抗体

hz-4042R Triosephosphate isomerase  磷酸丙糖异构酶抗体

hz-1151R TRBF1/TRF1  端粒体复制结合因子1抗体

hz-2722R TRhz1  髓系细胞触发受体1抗体

hz-2723R TRhz2  髓系细胞触发受体2抗体

hz-2724R TRhzL1/TLT1  髓系细胞触发受体样转录因子1抗体

hz-2737R TRhzL2/TLT2  髓系细胞触发受体样转录因子2抗体

hz-5907R Ferritin  铁蛋白抗体

hz-2052R Transferrin  转铁蛋白抗体

hzm-2052M Transferrin(1F10)  转铁蛋白单克隆抗体

hz-1922R TRF2  端粒结合蛋白2抗体

hz-1909R Telomerase Binding Protein, P23  端粒酶结合蛋白P23抗体

hz-4020R phospho-p23 (Ser113)  磷酸化端粒酶结合蛋白P23抗体

hz-0964R TRIM32  TRIM32抗体

hz-0193R TrK A/NTRK1  酪氨酸激酶A抗体

hz-3456R Phospho-TrkA (Tyr490)/TrkB (Tyr516)  磷酸化酪氨酸激酶A抗体

hz-3457R Phospho-TrkA (Tyr674/675)/TrkB (Tyr706/707)  磷酸化酪氨酸激酶A抗体

hz-3732R Phospho-TrkA (Tyr785)/TrkB (Tyr816)  磷酸化酪氨酸激酶A抗体

hz-0192R Trk A/B/C  酪氨酸激酶A/B/C抗体

hz-0175R Trk B/NTRK2  酪氨酸激酶B抗体

hz-0288R Trk B/NTRK2  酪氨酸激酶B抗体

hz-5525R phospho-NTRK2/TrkB (Tyr515)  磷酸化酪氨酸激酶B抗体

hz-5526R phospho-TrkB (Tyr705)  磷酸化酪氨酸激酶B抗体

hz-0176R Trk C  酪氨酸激酶C抗体(神经生长因子受体的一种)

hz-1243R Trop-2  原肌球蛋白抗体

hz-1511R TRP2  酪氨酸酶相关蛋白2抗体

hz-2393R TRPC6  瞬时受体电位离子通道蛋白6抗体

hz-0458R Thioredoxin  硫氧还蛋白抗体

hz-1605R TRP1/gp75  酪氨酸酶相关蛋白1抗体