磷酸化形态发生紊乱关联激活因子1抗体

英文名称    phospho-DAAM1 (Thr361)    

中文名称    磷酸化形态发生紊乱关联激活因子1抗体    

别    名    DAAM 1; DAAM-1; Dishevelled associated activator of morphogenesis 1; FLJ41657; KIAA0666.    

说 明 书    0.1ml      

产品类型    磷酸化抗体     

研究领域    肿瘤  免疫学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Rabbit, Sheep, Guinea Pig,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 磷酸化形态发生紊乱关联激活因子1抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    120-130kDa    

细胞定位    细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated Synthesised phosphopeptide derived from human DAAM1 around the phosphorylation site of Thr361 [SA(p-T)QM]    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

磷酸化形态发生紊乱关联激活因子1抗体产品介绍    background:

DAAM1 (Dishevelled associated activator of morphogenesis 1) is a diaphanous-related formin which binds to dishevelled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex assembly. It is an essential component of noncanonical Wnt signaling. DAAM1 also communicates with Rho GTPases, CIP4 and Src in the regulation of the signalling pathways that co-ordinate the dynamics of the actin filament system. DAAM1 may be a coordinator of endocytosis and cytoskeletal remodeling.

Function:
Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments.

Subunit:
Homodimer. Interacts with CIP4, FNBP1 and FNBP1L. Interacts with the SH3 domains of Abl, BTK, endophilin, spectrin and SRC. Binds specifically to GTP-bound CDC42 and RHOA. 

Subcellular Location:
Cytoplasm. Note=Perinuclear.

Tissue Specificity:
Expressed in all tissues examined.

Similarity:
Belongs to the formin homology family. 
Contains 1 DAD (diaphanous autoregulatory) domain. 
Contains 1 FH1 (formin homology 1) domain. 
Contains 1 FH2 (formin homology 2) domain. 
Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain. 

Database links:
UniProtKB/Swiss-Prot: Q9Y4D1.2    

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