磷酸化D酪氨酸激酶衰减蛋白1抗体

英文名称    phospho-DOK1(Tyr362)    

中文名称    磷酸化D酪氨酸激酶衰减蛋白1抗体    

别    名    DOK1 (phospho Y362); DOK1 (phospho Tyr362); p-DOK1 (phospho Y362); docking protein 1 (downstream of tyrosine kinase 1); Docking protein 1 (p62(dok)) (Downstream of tyrosine kinase 1) (pp62).; docking protein 1 62kD (downstream of tyrosine kinase 1); Docking protein 1 62kD; Docking protein 1 62kD; Docking protein 1; DOK 1; DOK1; DOK-1; DOK1_HUMAN; Downstream of tyrosine kinase 1; p62(dok); P62DOK; pp62; pp62.    

说 明 书    0.1ml      

产品类型    磷酸化抗体     

研究领域    肿瘤  心血管  信号转导  细胞凋亡  G蛋白偶联受体      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500 磷酸化D酪氨酸激酶衰减蛋白1抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    62kDa    

细胞定位    细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated Synthesised phosphopeptide derived from human DOK1 around the phosphorylation site of Tyr362    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

磷酸化D酪氨酸激酶衰减蛋白1抗体产品介绍    background:

Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.

Function:
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.

Subunit:
Interacts with ABL1 (By similarity). Interacts with RasGAP and INPP5D/SHIP1. Interacts directly with phosphorylated ITGB3.

Subcellular Location:
Isoform 1: Cytoplasm. Isoform 3: Cytoplasm, perinuclear region.

Tissue Specificity:
Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells.

Post-translational modifications:
Constitutively tyrosine-phosphorylated. Phosphorylated by TEC. Phosphorylated by LYN.
Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway.
Isoform 3 contains a N-acetylmethionine at position 1.

Similarity:
Belongs to the DOK family. Type A subfamily.
Contains 1 IRS-type PTB domain.
Contains 1 PH domain.

Database links:
UniProtKB/Swiss-Prot: Q99704.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

磷酸化D酪氨酸激酶衰减蛋白1抗体

hz-9666R CGI62/C8orf70  8号染色体开放阅读框70抗体

hz-9667R DENND2C  MAP激酶激活死亡域蛋白2C抗体

hz-9668R DENND2D  MAP激酶激活死亡域蛋白2D抗体

hz-9669R DENND4C  MAP激酶激活死亡域蛋白4C抗体

hz-9670R DHFRL1  二氢叶酸还原酶样1抗体

hz-1570R APOH  载脂蛋白H抗体

hz-9671R ASH1L  ASH1蛋白抗体

hz-9672R LAS2/C18orf54  肺腺瘤易感蛋白2抗体

hz-9673R Mel18/ZNF144  锌指蛋白蛋白144抗体

hz-9674R MYLIP/Idol  低密度脂蛋白受体的诱导降解蛋白抗体

hz-9675R C18orf56  18号染色体开放阅读框56抗体

hz-9676R MIC1/C18orf8  结肠癌相关蛋白MIC1抗体

hz-9677R C19orf18  19号染色体开放阅读框18抗体

hz-9678R C19orf21  19号染色体开放阅读框21抗体

hz-9679R C19orf24  19号染色体开放阅读框24抗体

hz-9680R MFSD12/C19orf28  19号染色体开放阅读框28抗体

hz-9681R C19orf45  19号染色体开放阅读框45抗体

hz-9682R C19orf46  19号染色体开放阅读框46抗体

hz-9683R C19orf47  19号染色体开放阅读框47抗体

hz-9684R C19orf54  19号染色体开放阅读框54抗体

hz-9685R C1GALT1  N-乙酰半乳糖胺糖蛋白3、β-半乳糖转移酶1抗体

hz-9686R VGLUT2  囊泡谷氨酸转运蛋白2抗体

hz-9687R Phospho-BLNK(Tyr84)  磷酸化T淋巴细胞连接蛋白抗体

hz-9688R Phospho-BLNK(Tyr491)  磷酸化T淋巴细胞连接蛋白抗体

hz-9689R TWA1/C20orf11  20号染色体开放阅读框11抗体

hz-9690R C20ORF141  20号染色体开放阅读框141抗体

hz-9691R C20orf103  20号染色体开放阅读框103抗体

hz-9692R C20orf111  过氧化氢诱导转录蛋白1抗体

hz-9693R C20orf112  20号染色体开放阅读框112抗体

hz-9694R C20orf132  20号染色体开放阅读框132抗体

hz-9695R C20orf160  20号染色体开放阅读框160抗体

hz-9696R KIZUNA/C20orf19  20号染色体开放阅读框19抗体

hz-9697R C20orf194  20号染色体开放阅读框194抗体

hz-9698R C20orf195  20号染色体开放阅读框195抗体

hz-9699R C20orf196  20号染色体开放阅读框196抗体

hz-0167R APOE/Apo E2  载脂蛋白E抗体

hz-9700R C20orf43  20号染色体开放阅读框43抗体

hz-9701R GPCR GPR97  G蛋白偶联受体97抗体

hz-9702R HECA  HECA蛋白抗体

hz-5039R APOE3  载脂蛋白E3抗体

hz-9703R Hornerin/S100A18  角化蛋白S100A16抗体

hz-9704R IFI35  干扰素诱导35蛋白抗体

hz-5038R APOE4/Apolipoprotein E4  载脂蛋白E4抗体

hz-9705R ITM2A  完整膜蛋白E25A抗体