结肠直肠癌缺失基因抗体

英文名称    DCC    

中文名称    结肠直肠癌缺失基因抗体    

别    名    Deleted in Colorectal Cancer; Igdcc1; Immunoglobulin domain cell adhesion molecule; Colorectal cancer related chromosome sequence 18; Colorectal cancer suppressor; CRC 18; CRC18; CRCR 1; CRCR; Deleted in colorectal cancer protein; Deleted in colorectal carcinoma; Netrin receptor DCC; Tumor suppressor protein DCC; DCC_RAT; DCC_HUMAN.    

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  细胞生物  神经生物学  信号转导  细胞凋亡  转录调节因子  细胞膜受体      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 结肠直肠癌缺失基因抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    158kDa    

细胞定位    细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human DCC    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

结肠直肠癌缺失基因抗体产品介绍    background:

Deleted in colorectal cancer (DCC, chromosome 18q21) was originally identified as a putative tumor suppressor gene that is lost in more than 70% of colorectal cancers. The gene has also been deleted in several other types of cancer. The DCC protein is a type I transmembrane glycoprotein that belongs to the immunoglobulin (Ig) superfamily. The extracellular domain is composed of four Ig like domains and six fibronectin type III repeats. Native DCC is found in three isoforms. Two forms, a long and a short isoform, are produced from the same gene but have different initiation sites. The third isoform, produced by alternative splicing, is expressed only in embryonic tissue. Mouse DCC extracellular domain shares 97% and 99% homology with human and rat DCC extracellular domains, respectively. In adults, DCC is highly expressed in the brain but is also expressed at very low levels in multiple normal tissues. In the embyro, high levels of expression are detected in the brain and neural tube. DCC functions as a receptor or a component of a receptor for netrins and mediates the effects of netrins on commissural axons. Netrins are chemoattractants responsible for the guidance of commissural axons at the midline and of motor axons to the their target muscles. DCC induces apoptosis in the absence of ligand binding, blocks apoptosis when engaged by netrin 1, and also acts as a caspase substrate.

Function:
Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.    

结肠直肠癌缺失基因抗体

hz-4567R EGF  表皮生长因子抗体

hz-4568M EGF  小鼠抗表皮生长因子抗体

hz-4568R EGF  抗表皮生长因子抗体

hz-4587R IL-6  白介素6抗体

hz-4588R IGF I  胰岛素样生长因子1抗体

hz-4590R PPAR Gamma  过氧化酶活化增生受体γ抗体

hz-4210R C9orf156  9号染色体开放阅读框156抗体

hz-4592R P14ARF/CDKN2A  抑癌基因p16抗体

hz-4593R MMP9  基质金属蛋白酶9抗体

hz-4600R TIMP-1(CT)  金属蛋白酶组织抑制因子-1抗体（C端）

hz-1114R Adducin protein  内收蛋白抗体

hz-4601R phospho-c-Jun(Thr91+Thr93)  磷酸化原癌基因c-Jun抗体

hz-4606R Gibberellins  抗赤霉素抗体

hz-4610R phospho-AQP2(Ser264/261)  磷酸化水通道蛋白2抗体

hz-4622R Mycobacterium bovis  牛结核杆菌菌体蛋白抗体

hz-4625R CK12/Cytokeratin 12  细胞角蛋白12抗体

hz-4626R HE4/Epididymal secretory protein E4  附睾分泌蛋白4抗体

hz-4631R Beta galactosidase  β半乳糖苷酶抗体

hz-4636R NR2C2/TAK1  孤儿核受体TAK1抗体

hz-4642R Kilham Rat Virus/KRV-VP1/KRV-VP2 (C-terminus)  基尔曼氏细小病毒VP1/VP2抗体(大鼠潜在病毒KRV)C端

hz-4643R Kilham Rat Virus/KRV-VP1/KRV-VP2 (C-terminus)  基尔曼氏细小病毒VP1/VP2抗体(大鼠潜在病毒KRV)C端

hz-4646R Capsid protein VP1  大鼠细小病毒H-1株(H-1)抗体（N端）

hz-4652R CRLF2  胸腺基质淋巴细胞生成素受体抗体

hz-4653R ASB10  含锚蛋白重复序列-细胞因子信号抑制物盒蛋白家族10抗体

hz-4659R MARK4  丝氨酸/苏氨酸蛋白激酶MARK4抗体

hz-4660R phospho-MARK4(Ser423)  磷酸化丝氨酸/苏氨酸蛋白激酶MARK4抗体

hz-4662R phospho-TCF3/E2A/E47(Ser39)  磷酸化转录因子3抗体

hz-4678R IgHV/IgH  免疫球蛋白重链可变区抗体

hz-4684R Mammaglobin A  乳腺珠蛋白1抗体

hz-2778R ADK/AK  腺苷酸激酶抗体

hz-2231R AEG-1/LYRIC  AEG-1抗体

hz-4687R AMH/MIS  Muellerian缪勒管激素抑制因子抗体

hz-4688R Glutaminase  谷氨酰胺酶抗体

hz-4689R Visfatin-1(CT)  内脂素/内脏脂肪素(C端抗体)