剪切及多聚腺苷酸化特异因子蛋白2抗体

英文名称    CPSF2    

中文名称    剪切及多聚腺苷酸化特异因子蛋白2抗体    

别    名    Cleavage and polyadenylation specific factor 2; Cleavage and polyadenylation specificity factor 100 kDa subunit; Cleavage and polyadenylation specificity factor subunit 2; CPSF 100 kDa subunit; CPSF 2; CPSF100; KIAA1367.    

说 明 书    0.1ml  0.2ml      

研究领域    染色质和核信号  细胞分化  表观遗传学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Cow, Horse, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 剪切及多聚腺苷酸化特异因子蛋白2抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    88kDa    

细胞定位    细胞核     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human CPSF2    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

剪切及多聚腺苷酸化特异因子蛋白2抗体产品介绍    background:

CPSF contains four subunits and localizes to the nucleoplasm where it recognizes the AAUAAA signal in pre-mRNA and interacts with other proteins to facilitate RNA cleavage and poly(A) synthesis (1,4,5). The human CPSF2 gene maps to chromosome 14q32.12 and encodes the second largest subunit of cleavage and polyadenylation specificity factor. U1 snRNP-A protein (U1A) interacts with and affects the activity of CPSF by stabilizing the interaction of CPSF with the AAUAAA-containing RNAs to increase the efficiency of polyadenylation . 

Function:
CPSF2 belongs to the RNA-metabolizing metallo-beta-lactamase-like family, CPSF2/YSH1 subfamily. It is a component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3 prime-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. A poly(A) tail is added to eukaryotic mRNA precursors after tightly coupled cleavage and polyadenylation reactions at their 3-prime ends. 
剪切及多聚腺苷酸化特异因子蛋白2抗体

hz-3727R phospho-PKC delta (Thr505)  磷酸化蛋白激酶C亚性D型抗体

hz-3728R phospho-PKC delta (Tyr311)  磷酸化蛋白激酶C亚性D型抗体

hz-5565R phospho-PRKCB(Ser660)  磷酸化蛋白激酶C抗体

hz-5559R phospho-PKC delta (Ser645)  磷酸化蛋白激酶C亚性D型抗体

hz-5566R phospho-PRKCB(Ser642)  磷酸化蛋白激酶C抗体

hz-5573R phospho-PRKCA(Ser657+Tyr658)  磷酸化蛋白激酶C抗体

hz-5574R phospho-PRKCA(Thr637)  磷酸化蛋白激酶C抗体

hz-1098R PLAU/UPA/Urokinase  尿激酶型纤溶酶原激活因子抗体

hz-1927R PLAUR/CD87  尿激酶型纤溶酶原激活因子受体抗体

hz-1828R Plasminogen  纤维蛋白溶酶原抗体

hz-2692R Plexin A1  神经丛蛋白A1抗体

hz-3638R Plexin A2  神经丛蛋白A2抗体

hz-2693R Plexin B1  神经丛蛋白B1抗体

hz-3640R Plectin  网蛋白抗体

hz-0281R PLGF/PIGF (human)  胎盘生长相关抗体（人）

hz-0280R PLGF/PIGF (mouse, rat, pig)  胎盘生长因子抗体（小鼠、大鼠、猪）

hz-0234R PLGF  胎盘生长因子抗体

hz-3535R PLK1  丝氨酸/苏氨酸蛋白激酶Plk1抗体

hz-3344R Phospho-PLK1(Thr210)  磷酸化丝/苏氨酸蛋白激酶Plk1抗体

hz-3345R Phospho-PLK1 (Ser137)  磷酸化丝/苏氨酸蛋白激酶Plk1抗体

hz-5588R Phospho-PLK1(Ser482+Ser486+Ser490)  磷酸化丝/苏氨酸蛋白激酶Plk1抗体

hz-3698R PML/TRIM19  早幼粒细胞白血病蛋白抗体

hz-0235R PMP22  外周髓鞘蛋白-22抗体

hz-1362R PMS2  肿瘤错配修复基因PMS2抗体

hz-2798R PNAT/NAT2  N-乙酰基转移酶2抗体

hz-3542R PNK1/PNKP  多聚合苷酸激酶3磷酸化酶抗体

hz-3355R Phospho-PNK1 (Ser114/Thr118)  磷酸化多聚合苷酸激酶3磷酸化酶抗体

hz-3912R PNMT  苯乙醇胺甲基转移酶抗体

hz-5108R PNPO  磷酸吡哆醇氧化酶抗体

hz-1048R Podoplanin Protein/gp36  平足蛋白抗体(淋巴管内皮细胞蛋白)

hz-0891R Pokhzon  扑克蒙蛋白抗体

hz-2157R Polycystin 1  多囊肾蛋白1抗体

hz-2158R Polycystin 2  多囊肾蛋白2抗体