1号染色体开放阅读框77抗体

英文名称    C1orf77    

中文名称    1号染色体开放阅读框77抗体    

别    名    Chromatin target of PRMT1 protein; Chromosome 1 open reading frame 77; CHTOP; CHTOP_HUMAN; DKFZp547E1010; FOP; Friend of PRMT1 protein; MGC131924; MGC86949; OTTHUMP00000035122; OTTHUMP00000035123; Pp7704; RP1 178F15.2; Small arginine- and glycine-rich protein; Small protein rich in arginine and glycine; SRAG.    

说 明 书    0.2ml      

研究领域    细胞生物  免疫学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 1号染色体开放阅读框77抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    26kDa    

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human C1orf77    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

产品介绍    background:1号染色体开放阅读框77抗体

C1orf77, also known as Friend of PRMT1 protein, is a 248 amino acid protein that plays an essential role in the ligand-dependent activation of estrogen receptor target genes. C1orf77 is tightly associated with chromatin and is modified by both asymmetric and symmetric arginine methylation. Depletion of C1orf77 results in almost complete block of estradiol-induced promter occupancy by the estrogen receptor. Also, complete knockdown of C1orf77 mRNA in adult erythroid progenitors stongly induces fetal hemoglobin, suggesting that C1orf77 is a critical modulator of γ-globin gene expression. There are two isoforms of C1orf77 that are produced as a result of alternative splicing events. The gene encoding C1orf77 maps to human chromosome 1, the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1.

Function:
Plays an important role in the ligand-dependent activation of estrogen receptor target genes. May play a role in the silencing of fetal globin genes. Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.     

1号染色体开放阅读框77抗体

hz-0327P-APhz Bovine IgM/APC  荧光素APC标记牛IgM

hz-0310P-APhz Chicken IgG/APC  荧光素APC标记鸡IgG

hz-0314P-APhz Chicken IgM/APC  荧光素APC标记鸡IgM

hz-0303P-APhz dog IgG/APC  荧光素APC标记狗IgG

hz-0373P-APhz dog IgM/APC  荧光素APC标记狗IgM

hz-0370P-APhz Goat IgM/APC  荧光素APC标记羊IgM

hz-0358P-APhz Guinea IgG/APC  荧光素APC标记豚鼠IgG

hz-0375P-APhz Guinea IgM/APC  荧光素APC标记豚鼠IgM

hz-0308P-APhz Horse IgG/APC  荧光素APC标记马IgG

hz-0374P-APhz Horse IgM/APC  荧光素APC标记马IgM

hz-0297P-APhz human IgG/APC  荧光素APC标记人IgG

hz-0345P-APhz human IgM/APC  荧光素APC标记人IgM

hz-0360P-APhz human IgA/APC  荧光素APC标记人IgA

hz-0335P-APhz Monkey IgG/APC  荧光素APC标记猴IgG

hz-0336P-APhz Monkey IgM/APC  荧光素APC标记猴IgM

hz-0368P-APhz Mouse IgM/APC  荧光素APC标记小鼠IgM

hz-0309P-APhz pig IgG/APC  荧光素APC标记猪IgG

hz-0369P-APhz Rabbit IgM/APC  荧光素APC标记兔IgM

hz-0346P-APhz Rat IgM/APC  荧光素APC标记大鼠IgM

hz-0789P-APhz Insulin Protein /APC  荧光素APC标记猪胰岛素蛋白

hz-P0002-APhz KLH/APC  荧光素APC标记血蓝蛋白

hz-P0003-APhz OVA/APC  荧光素APC标记鸡卵白蛋白

hz-0945P-APhz HSA(Human sermu albumin)/APC  荧光素APC标记人血白蛋白

hz-2179P-APhz AACT/APC  荧光素APC标记胰糜蛋白酶

hz-0437P-hzy3 Streptavidin/Cy3  荧光素Cy3标记链霉亲和素

hz-0312P-hzy3 Avidin/Cy3  荧光素Cy3标记亲合素

hz-0362P-hzy3 Protein A/Cy3  Cy3标记蛋白A

hz-0295P-hzy3 Rabbit IgG/Cy3  荧光素Cy3标记兔IgG(细胞流式同型对照)

hz-0296P-hzy3 Mouse IgG/Cy3  荧光素Cy3标记小鼠IgG(细胞流式同型对照)

hz-0294P-hzy3 Goat IgG/Cy3  荧光素Cy3标记羊IgG(细胞流式同型对照)

hz-0293P-hzy3 Rat IgG/Cy3  荧光素Cy3标记大鼠IgG(细胞流式同型对照)

hz-0326P-hzy3 Bovine IgG/Cy3  荧光素Cy3标记牛IgG

hz-0327P-hzy3 Bovine IgM/Cy3  荧光素Cy3标记牛IgM

hz-0310P-hzy3 Chicken IgG/Cy3  荧光素Cy3标记鸡IgG

hz-0314P-hzy3 Chicken IgM/Cy3  荧光素Cy3标记鸡IgM

hz-0303P-hzy3 dog IgG/Cy3  荧光素Cy3标记狗IgG

hz-0373P-hzy3 dog IgM/Cy3  荧光素Cy3标记狗IgM

hz-0370P-hzy3 Goat IgM/Cy3  荧光素Cy3标记羊IgM

hz-0358P-hzy3 Guinea pig IgG/Cy3  荧光素Cy3标记豚鼠IgG