胞粘蛋白2抗体

英文名称    Cytohesin 2    

中文名称    胞粘蛋白2抗体    

别    名    ARF exchange factor; ARF nucleotide binding site opener; Arno; ARNO protein; CLM2; CTS18; CTS18.1; Cyth2; Cytohesin 2; MGC137537; MGC80440; PH, SEC7 and coiled-coil domain-containing protein 2; Pleckstrin homology Sec7 and coiled coil domains 2; Pleckstrin homology Sec7 and coiled coil domains protein 2; PSCD2; PSCD2L; PSCD2L, formerly; Sec7; SEC7 homolog B; Sec7B; SEC7L; Sec7p L; Sec7p-like; Sec7pL; CYH2_HUMAN.    

说 明 书    0.2ml      

研究领域    细胞生物  信号转导  细胞粘附分子  G蛋白偶联受体  细胞骨架  G蛋白信号      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 胞粘蛋白2抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    47kDa    

细胞定位    细胞浆 细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Cytohesin 2    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

胞粘蛋白2抗体产品介绍    background:

The ADP-ribosylation factor (Arf) family comprises a group of structurally and functionally conserved 21 kDa proteins, which are members of the Ras superfamily of regulatory GTP-binding proteins. Arf is involved in intracellular protein traffic to and within the Golgi complex. Arf has a number of disparate activities including maintenance of organelle integrity, assembly of coat proteins, as a co-factor for cholera toxin and as an activator of phospholipase D. Like other small GTPases, Arf is found to be active when bound to GTP and inactive when bound to GDP. Arf’s activation is dependent upon guanine nucleotide exchange factors (GEFs) which increase the rate of exchange of bound GDP with GTP. All GEFs have a highly conserved Sec7 domain. GEF activity lies in the Sec7 domain and this activity has been shown to be inhibited by the fungal metabolite brefeldin-A (BFA). A small group of GEFs which are insensitive to brefeldin-A (BFA) include cytohesin-1 (B2-1), cytohesin-2 (ARNO), cytohesin-3 (ARNO3), and cytohesin-4. All cytohesins function in the cell periphery and contain a pleckstrin homology (PH) domain. The PH domain has been shown to interact with phosphatidylinositol 3,4,5-triphosphate and is believed to promote membrane targeting of the cytohesins. Recruitment of the cytohesins to the membranes can occur in response to tyrosine kinase receptor activation. This response appears to require the activation of phosphatidylinositol 3-kinase (PI 3-kinase). 

Function:
Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane.    

胞粘蛋白2抗体

hz-5029R SAHH  S腺苷L-同型半胱氨酸水解酶

hz-1609R SATB1  核基质结合区结合蛋白1抗体

hz-3390R Phospho-SATB1 (Ser47)  磷酸化核基质结合区结合蛋白1抗体

hz-3752R Sca1/Ly6A/E  T淋巴细胞激活蛋白抗体

hz-3787R SCD1  固醇酰辅酶A脱氢酶1抗体

hz-0545R SCF  干细胞生长因子抗体

hz-1888R SCG3/SgIII  分泌粒蛋白3抗体

hz-1889R SCN1A  SCN1A抗体

hz-2916R SPINK1/SPINK3  肿瘤相关胰蛋白酶抑制剂1抗体

hz-2917R SPINK1/SPINK3  肿瘤相关胰蛋白酶抑制剂1抗体

hz-1890R SCN2A  SCN2A抗体

hz-2427R SCN9A/NAV1.7  电压开启的钠离子通道SCN9A抗体

hz-2014R SCP2/NLTP  固醇携带蛋白2抗体

hz-3509R SCP3  联会复合体蛋白3抗体

hz-2121R SCYLV  甘蔗SCYLV抗体

hz-0783R SDF-1/CXCL12  基质细胞衍生因子－1抗体

hz-1503R CXCL14  CXC趋化因子14抗体

hz-3049R Phospho-Aurora B(Thr232)/Aurora C(Thr198)  磷酸化有丝分裂激酶B/C抗体

hz-3050R Phospho-Aurora A(Thr288)  磷酸化有丝分裂激酶A抗体

hz-1441R CXCL16  CXC趋化因子16抗体

hz-0088R Secretin  分泌素抗体

hz-3862R SCAP/SREBF chaperone protein  固醇调节元件结合蛋白裂解激活蛋白抗体

hz-0089R Secretin receptor  分泌素受体抗体

hz-1891R SEL1L  SEL1L抗体

hz-0495R Selenoprotein W  硒蛋白W抗体

hz-1121R Shza3A  臂板蛋白3A抗体

hz-5817R Shzaphorin 3B  导向蛋白3B抗体

hz-1122R Shza3F  臂板蛋白3F抗体

hz-1123R Shza4C/ShzA5A  臂板蛋白4C抗体

hz-2701R Shza6A  Shza6A抗体

hz-2702R Shza7A/CD108  轴突生长因子CD108抗体

hz-4035R SENP3  类泛素蛋白3抗体

hz-1303R SFRP1  分泌型卷曲相关蛋白1抗体