甲状腺受体相互作用蛋白15抗体

英文名称    COPS2    

中文名称    甲状腺受体相互作用蛋白15抗体    

别    名    ALIEN; Alien homolog; COP 9; COP9; COP9 constitutive photomorphogenic homolog subunit 2; COP9 signalosome complex subunit 2; COPS 2; Cops2; CSN2; CSN2_HUMAN; JAB1 containing signalosome subunit 2; JAB1-containing signalosome subunit 2; SGN 2; SGN2; Signalosome subunit 2; Thyroid Hormone Receptor Interactor15; Thyroid Hormone Receptor Interactor 15; Thyroid receptor-interacting protein 15; TR-interacting protein 15; TRIP 15; TRIP-15.    

说 明 书    0.2ml      

研究领域    细胞生物  免疫学  染色质和核信号  信号转导  转录调节因子  表观遗传学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-100 IF=1:50-200 甲状腺受体相互作用蛋白15抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    51kDa    

细胞定位    细胞核 细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human COPS2/TRIP15    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

甲状腺受体相互作用蛋白15抗体产品介绍    background:

Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.

Function:
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.    

甲状腺受体相互作用蛋白15抗体

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hz-7998R CEACAM16/CEAL2  癌胚抗原相关细胞粘附分子16抗体

hz-7999R CEACAM19/CEAL1  癌胚抗原相关细胞粘附分子19抗体

hz-8012R ADCK5  ADCK5蛋白抗体

hz-8013R ITGB1BP2/CHORDC3  整合素β1结合蛋白2抗体

hz-8014R CLDND2  膜蛋白CLDND2抗体

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hz-8016R CLN3  神经细胞蜡样质脂褐质沉积病蛋白CLN3抗体

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hz-8018R CLPTM1  唇裂和腭裂相关跨膜蛋白1抗体

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hz-8022R CKLFH4/CMTM4  趋化素样因子超家族成员4抗体

hz-8023R CKLFH5/CMTM5  趋化素样因子超家族成员5抗体

hz-8024R CKLFH8/CMTM8  趋化素样因子超家族成员8抗体

hz-8025R CKLFH6/CMTM6  趋化素样因子超家族成员6抗体

hz-8026R CKLFSF7/CMTM7  趋化素样因子超家族成员7抗体

hz-8027R CNIH3/CNIH2  cornichon样蛋白抗体

hz-8028R CNKSR1  Ras激酶抑制因子连接增强蛋白1抗体

hz-8029R CNKSR2  Ras激酶抑制因子连接增强蛋白2抗体

hz-8030R CNKSR3  Ras激酶抑制因子连接增强蛋白3抗体

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