信号转导蛋白亚基4抗体

英文名称    COPS4    

中文名称    信号转导蛋白亚基4抗体    

别    名    CH4; COP9 (constitutive photomorphogenic) homolog subunit 4; COP9 complex homolog subunit 4; COP9 complex S4; COP9 constitutive photomorphogenic homolog subunit 4; COP9 signalosome complex subunit 4; COP9 signalosome subunit 4; COPS4; CSN complex subunit 4; CSN4; CSN4 SCHPO; CSN4_HUMAN; DCH4; JAB1 containing signalosome subunit 4; JAB1-containing signalosome subunit 4; MGC94896; SGN4; Signalosome subunit 4.    

说 明 书    0.2ml      

研究领域    细胞生物  免疫学  神经生物学  信号转导  激酶和磷酸酶      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Cow, Horse,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）信号转导蛋白亚基4抗体 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    46kDa    

细胞定位    细胞核 细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human COPS4    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

信号转导蛋白亚基4抗体产品介绍    background:

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. 

Function:
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.    

信号转导蛋白亚基4抗体

hz-7918R PLK5  丝氨酸/苏氨酸蛋白激酶5抗体

hz-7919R phospho-MST1R(Tyr1353)   磷酸化原癌基因c-Met相关酪氨酸激酶抗体

hz-7920R MAPK13/SAPK4/p38delta  丝裂原活化蛋白激酶13抗体

hz-7921R Robo2  轴突导向受体蛋白2抗体

hz-7922R SKAR  DNA聚合酶δ相互作用蛋白3抗体

hz-7923R SRPK2  丝氨酸/苏氨酸蛋白激酶SRPK2抗体

hz-7924R TBRG4  转化生长因子β调节蛋白4抗体

hz-7925R TLK2  丝氨酸/苏氨酸激酶TLK2抗体

hz-7926R ANKRD28  锚蛋白重复域28抗体

hz-7927R SIPA1L2  信号诱导增殖相关蛋白1样蛋白2抗体

hz-7928R DUSP7  双特异性蛋白磷酸酶7抗体

hz-7929R PPM1B  蛋白质磷酸酶1B抗体（PP2Cβ）

hz-7930R PPM1G  蛋白质磷酸酶1G抗体（PP2Cγ）

hz-7931R PPP2R1A  蛋白质磷酸酶2调节亚基1A抗体

hz-7932R PPP2R1B  蛋白质磷酸酶2调节亚基1B抗体

hz-7933R PPP2R3A  蛋白质磷酸酶2调节亚基3A抗体

hz-7934R SHOC2/Sur8  富含亮氨酸重复蛋白SHOC2抗体

hz-7935R RAMP/CDT2  维甲酸调节核基质相关蛋白

hz-7936R MTMR8  肌管素相关蛋白8抗体

hz-7937R NIFK  KI67相互作用蛋白抗体

hz-7938R phospho-NIFK/MKI67IP(Thr234)  磷酸化KI67相互作用蛋白抗体

hz-7939R TACC1  乳腺癌、胃癌抗原GA55抗体

hz-7941R ABCF3  三磷酸腺苷结合盒转运蛋白F亚基3抗体

hz-7942R ABHD1  肺α/β水解酶蛋白1抗体

hz-7943R ABHD13  水解酶结构域蛋白13抗体

hz-7945R ABHD14B  水解酶结构域蛋白14B抗体

hz-7946R ABHD15  水解酶结构域蛋白15抗体

hz-7947R ABHD3  肺α/β水解酶蛋白3抗体

hz-7948R ABHD4  α/β水解酶4抗体

hz-7950R ACBD4  酰基辅酶A结合结构域蛋白4抗体

hz-7951R ADCK1  ADCK1蛋白抗体

hz-7952R ADCK2  ADCK2蛋白抗体

hz-7953R AKR1A1  乙醇脱氢酶1抗体

hz-7954R ALAD  δ氨基乙酰丙酸脱水酶抗体