细胞周期调控因子34

英文名称    CDC34    

中文名称    细胞周期调控因子34    

别    名    Cdc 34; Cdc34; Cell division cycle 34; Cell division cycle 34 homolog (S. cerevisiae); Cell division cycle 34 homolog; E2 CDC34; UB2R1_HUMAN; UBC 3; UBC3; UBCH3; UBE2 R1; UBE2R1; Ubiquitin carrier protein; Ubiquitin conjugating enzyme Cdc34; Ubiquitin conjugating enzyme E2 32 kDa complementing; Ubiquitin protein ligase; Ubiquitin protein ligase R1; Ubiquitin-conjugating enzyme E2 R1; Ubiquitin-conjugating enzyme E2-32 kDa complementing; Ubiquitin-conjugating enzyme E2-CDC34; Ubiquitin-protein ligase R1    

说 明 书    0.1ml  0.2ml      

研究领域    细胞生物  细胞凋亡  细胞周期蛋白  转录调节因子      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Guinea Pig,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 细胞周期调控因子34（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    26kDa    

细胞定位    细胞核 细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Cdc34    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

细胞周期调控因子34产品介绍    background:

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Cooperates with the E2 UBCH5C and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Performs ubiquitin chain elongation building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. UBE2D3 acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Cooperates with the SCF(SKP2) E3 ligase complex to regulate cell proliferation through ubiquitination and degradation of MYBL2 and KIP1. Involved in ubiquitin conjugation and degradation of CREM isoform ICERIIgamma and ATF15 resulting in abrogation of ICERIIgamma- and ATF5-mediated repression of cAMP-induced transcription during both meiotic and mitotic cell cycles. Involved in the regulation of the cell cycle G2/M phase through its targeting of the WEE1 kinase for ubiquitination and degradation. Also involved in the degradation of beta-catenin. Is target of human herpes virus 1 protein ICP0, leading to ICP0-dependent dynamic interaction with proteasomes.    

细胞周期调控因子34

hz-0336Rs Rabbit anti-Monkey IgM whole serum  兔抗猴IgM抗血清

hz-0296Rs Rabbit anti-mouse IgG whole serum  兔抗小鼠IgG抗血清

hz-0368Rs Rabbit anti-mouse IgM whole serum  兔抗小鼠IgM抗血清

hz-0330Rs Rabbit anti-mouse Kappa Chain whole serum  兔抗小鼠k-链抗血清

hz-0377Rs Rabbit anti-mouse IgG-Fc fragment whole serum  兔抗小鼠IgG-Fc段抗血清

hz-0293Rs Rabbit anti-Rat IgG whole serum  兔抗大鼠IgG抗血清

hz-0346Rs Rabbit anti-Rat IgM whole serum  兔抗大鼠IgM抗血清

hz-0309Rs Rabbit anti-Pig IgG whole serum  兔抗猪IgG抗血清

hz-0403Rs Rabbit anti-MG IgG whole serum  兔抗长爪沙鼠IgG抗血清

hz-0297Ds Donkey anti-human IgG whole serum  驴抗人IgG抗血清

hz-0295Ds Donkey anti-Rabbit IgG whole serum  驴抗兔IgG抗血清

hz-0294Ds Donkey anti-Goat IgG whole serum  驴抗羊IgG抗血清

hz-0358Ds Donkey anti-Gpig IgG whole serum  驴抗豚鼠IgG抗血清

hz-0374R Rabbit Anti-horse IgM  兔抗马IgM

hz-0326G Goat Anti-Bovine IgG  羊抗牛IgG

hz-0296G Goat Anti-Mouse IgG  羊抗小鼠IgG

hz-0368G Goat Anti-Mouse IgM  羊抗小鼠IgM

hz-0293G Goat Anti-rat IgG  羊抗大鼠IgG

hz-0358G Goat Anti-Guinea pig IgG  羊抗豚鼠IgG

hz-0295G Goat Anti-rabbit IgG  羊抗兔IgG

hz-0310G Goat Anti-Chicken IgG  羊抗鸡IgG

hz-0297G Goat Anti-human IgG  羊抗人IgG

hz-0345G Goat Anti-human IgM  羊抗人IgM

hz-0297M Mouse Anti-human IgG  小鼠抗人IgG

hz-0345M Mouse Anti-human IgM  小鼠抗人IgM

hz-0294M Mouse Anti-Goat IgG  小鼠抗羊IgG

hz-0295M Mouse Anti-rabbit IgG  小鼠抗兔IgG

hz-0369M Mouse Anti-Rabbit IgM  小鼠抗兔IgM

hz-0293M Mouse Anti-rat IgG  小鼠抗大鼠IgG

hz-0326M Mouse Anti-Bov IgG  小鼠抗牛IgG

hz-0358M Mouse Anti-Guinea pig IgG  小鼠抗豚鼠IgG