有丝分裂检验点蛋白BubR1抗体

英文名称    BubR1    

中文名称    有丝分裂检验点蛋白BubR1抗体    

别    名    Beta homolg of S. cerevisiae BUB 1; Beta homolg of S. cerevisiae budding uninhibited by benzimidazoles; BUB 1B; BUB1 budding uninhibited by benzimidazoles 1 homolog beta; Bub1A; BUB1B; BUB1B_HUMAN; BUB1beta; BUBR1; Budding Uninhibited by Benzimidazoles 1 beta; hBUBR1; MAD3/BUB1 related protein kinase; MAD3/BUB1-related protein kinase; MAD3L; Mitotic checkpoint gene BUB1B; Mitotic checkpoint kinase MAD3L; Mitotic checkpoint serine/threonine protein kinase BUB1 beta; Mitotic checkpoint serine/threonine-protein kinase BUB1 beta; Protein SSK1; SSK 1; SSK1.    

说 明 书    0.2ml      

研究领域    肿瘤  细胞生物  免疫学  染色质和核信号  细胞周期蛋白  激酶和磷酸酶      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Cow, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 有丝分裂检验点蛋白BubR1抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    120kDa    

细胞定位    细胞核 细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human BubR1    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

有丝分裂检验点蛋白BubR1抗体产品介绍    background:

This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq, Jul 2008]

Function:
Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression.    

有丝分裂检验点蛋白BubR1抗体公司更多热销抗体产品如下：

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hz-0377Rs Rabbit anti-mouse IgG-Fc fragment whole serum  兔抗小鼠IgG-Fc段抗血清

hz-0293Rs Rabbit anti-Rat IgG whole serum  兔抗大鼠IgG抗血清

hz-0346Rs Rabbit anti-Rat IgM whole serum  兔抗大鼠IgM抗血清

hz-0309Rs Rabbit anti-Pig IgG whole serum  兔抗猪IgG抗血清

hz-0403Rs Rabbit anti-MG IgG whole serum  兔抗长爪沙鼠IgG抗血清

hz-0297Ds Donkey anti-human IgG whole serum  驴抗人IgG抗血清

hz-0295Ds Donkey anti-Rabbit IgG whole serum  驴抗兔IgG抗血清

hz-0294Ds Donkey anti-Goat IgG whole serum  驴抗羊IgG抗血清

hz-0358Ds Donkey anti-Gpig IgG whole serum  驴抗豚鼠IgG抗血清

hz-0374R Rabbit Anti-horse IgM  兔抗马IgM

hz-0326G Goat Anti-Bovine IgG  羊抗牛IgG

hz-0296G Goat Anti-Mouse IgG  羊抗小鼠IgG

hz-0368G Goat Anti-Mouse IgM  羊抗小鼠IgM

hz-0293G Goat Anti-rat IgG  羊抗大鼠IgG

hz-0358G Goat Anti-Guinea pig IgG  羊抗豚鼠IgG

hz-0295G Goat Anti-rabbit IgG  羊抗兔IgG

hz-0310G Goat Anti-Chicken IgG  羊抗鸡IgG

hz-0297G Goat Anti-human IgG  羊抗人IgG

hz-0345G Goat Anti-human IgM  羊抗人IgM

hz-0297M Mouse Anti-human IgG  小鼠抗人IgG

hz-0345M Mouse Anti-human IgM  小鼠抗人IgM

hz-0294M Mouse Anti-Goat IgG  小鼠抗羊IgG

hz-0295M Mouse Anti-rabbit IgG  小鼠抗兔IgG

hz-0369M Mouse Anti-Rabbit IgM  小鼠抗兔IgM

hz-0293M Mouse Anti-rat IgG  小鼠抗大鼠IgG