免疫调节蛋白AIRE抗体

英文名称    AIRE    

中文名称    免疫调节蛋白AIRE抗体    

别    名    AIRE-1; AIRE; AIRE_HUMAN; AIRE1; APECED; APECED protein; APS1; APSI; Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein; Autoimmune regulator; Autoimmune regulator protein; PGA1.    

说 明 书    0.1ml  0.2ml      

研究领域    细胞生物  免疫学  信号转导  转录调节因子  锌指蛋白      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Horse,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 免疫调节蛋白AIRE抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    58kDa    

细胞定位    细胞核 细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human PGA1/AIRE    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

免疫调节蛋白AIRE抗体产品介绍    background:

The autoimmune regulator gene, which is defective in the hereditary auto-immune disease APECED, encodes the transcriptional activator AIRE. AIRE is expressed in the medullary epithelial cells and monocyte-dendritic cells of the thymus, with lower expression in the spleen, fetal liver and lymph nodes. In adult tissue, AIRE expression in the thymus is confined to the medulla and the cortico-medullary junction, where it is modulated by thymocytes undergoing negative selection. At the cellular level, AIRE is located in microtubular structures of the cyto-skeleton and in discrete nuclear dots resembling ND10 nuclear bodies. AIRE is induced by developing early thymocytes and is associated with the correct establishment of a regular thymic environment. AIRE regulates thymic architecture via transcriptional control of downstream target genes. AIRE mutations in APECED patients may affect thymic T cell selection and the formation of self-tolerance.

Function:
Transcriptional regulator that binds to DNA as a dimer or as a tetramer, but not as a monomer. Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-. ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes (By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Functions as a transcriptional activator and promotes the expression of otherwise tissue-specific self-antigens in the thymus, which is important for self tolerance and the avoidance of autoimmune reactions.    

免疫调节蛋白AIRE抗体公司更多热销抗体产品如下：

hz-0744R CEAcam8/CD67  癌胚抗原相关细胞粘附分子8抗体

hz-2956R PCGF1  表观抑制因子Polycomb家族成员PCGFl蛋白抗体

hz-2222R cellulase  纤维素酶抗体

hz-1630R CEBP-alpha  转录调节因子C/EBP α 抗体

hz-3060R Phospho-CEBP alpha (Ser21)  磷酸化转录调节因子CEBP α 抗体

hz-3061R Phospho-CEBP alpha (Thr222/226)  磷酸化转录调节因子CEBP α 抗体

hz-1396R CEBP Beta  转录调节因子C/EBP β抗体

hz-3062R Phospho-CEBP beta (Ser105)  磷酸化转录调节因子CEBP β抗体

hz-3063R Phospho-CEBP beta (Thr235)  磷酸化转录调节因子CEBP β抗体

hz-2753R CENPA  着丝粒蛋白A

hz-3066R Phospho-CENP-A (Ser7)  磷酸化着丝粒蛋白A

hz-2080R Cecropin  抗菌肽/天蚕素抗体

hz-2232R Cecropin  杀菌肽/天蚕抗菌肽抗体

hz-2373R Ceruloplasmin  铜蓝蛋白抗体

hz-3694R CETP  胆固醇酯转移蛋白抗体

hz-0125R HER2/NEU/ErbB2  HER2抗体

hz-0432R Chicken IgY  兔抗鸡IgY抗体

hz-2918R RAP1GAP  RAP1GAP酶激活蛋白抗体

hz-4284R RAD21  核基质蛋白21抗体

hz-1085R HER4/ErbB4  HER4抗体

hz-3184R Phospho-HER4 (Tyr984)  磷酸化HER4抗体

hz-3220R Phospho-HER4 (Tyr1284)  磷酸化HER4抗体

hz-5342R Phospho-HER4 (Tyr1162)  磷酸化HER4抗体

hz-5343R Phospho-HER4 (Tyr1188)  磷酸化HER4抗体

hz-0469R c-fos  c-fos抗体

hz-5736R TACC2/ AZU1  转化酸性卷曲含蛋白质2

hz-4285R TPX2  微管相关同源蛋白TPX2抗体

hz-3152R Phospho-c-Fos (Ser32)  磷酸化c-fos抗体