细胞核重定位及纺锤体检查点蛋白AMN1抗体

英文名称    AMN1    

中文名称    细胞核重定位及纺锤体检查点蛋白AMN1抗体    

别    名    AMN1; AMN1_HUMAN; Antagonist of mitotic exit network 1 homolog; Protein AMN1 homolog.    

说 明 书    0.2ml      

研究领域    细胞生物  免疫学  染色质和核信号      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 细胞核重定位及纺锤体检查点蛋白AMN1抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    28kDa    

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human AMN1    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

细胞核重定位及纺锤体检查点蛋白AMN1抗体产品介绍    background:

AMN1 is a 258 amino acid protein belonging to the AMN1 family. Encoded by a gene that maps to human chromosome 12p11.21, AMN1 contains twelve degenerate leucine-rich repeat (LRR) motifs and modulates Ste12 binding to promoters of multiple genes. As a daughter cell-specific protein, AMN1 inhibits ELL function to deactivate the mitotic exit state and reset the cell cycle in G1. AMN1 does not halt mitotic exit, but turns it off afterward. Induced by ELL after exit activation, AMN1 disrupts TEM1-Cdc15 interaction by competing with Cdc15 for TEM1 binding and by facilitating inactivation of Cdc14. Defects in AMN1 can result in disruption of both the spindle assembly and nuclear orientation checkpoints. AMN1 may also mediate gene activity and phenotypic diversity.

Similarity:
Belongs to the AMN1 family.    

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