轴抑制蛋白2抗体

英文名称    Axin 2    

中文名称    轴抑制蛋白2抗体    

别    名    Axil; Axin like protein; Axin-2; Axin-like protein; Axin2; Axis inhibition protein 2; AXIN2_HUMAN; Conductin.    

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  细胞生物  免疫学  神经生物学  信号转导  干细胞  细胞周期蛋白  转录调节因子      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Horse,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500轴抑制蛋白2抗体 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    93kDa    

细胞定位    细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Axin 2 corresponding to amino acids 756-795    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

轴抑制蛋白2抗体保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

产品介绍    background:

Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B.
Involvement in disease:Defects in AXIN2 are involved in colorectal cancer (CRC). They appear to be specifically associated with defective mismatch repair.
Defects in AXIN2 are the cause of oligodontia-colorectal cancer syndrome (ODCRCS). Affected individuals manifest severe tooth agenesis and colorectal cancer or precancerous lesions of variable types. 

Function:
Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B (By similarity).    

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hz-0403R-hzy3 Rabbit anti-MG IgG/Cy3  Cy3标记的兔抗长爪沙鼠IgG

hz-0403R-hzy5 Rabbit anti-MG IgG/Cy5  Cy5标记的兔抗长爪沙鼠IgG

hz-0403R-PE Rabbit anti-MG IgG/PE  PE标记的兔抗长爪沙鼠IgG

hz-0403R-PE-hzy3 Rabbit anti-MG IgG/PE-Cy3  PE-Cy3标记的兔抗长爪沙鼠IgG

hz-0403R-PE-hzY5 Rabbit anti-MG IgG/PE-CY5  PE-CY5标记的兔抗长爪沙鼠IgG

hz-0403R-PE-hzy7 Rabbit anti-MG IgG/PE-Cy7  PE-Cy7标记的兔抗长爪沙鼠IgG

hz-0403R-APhz Rabbit anti-MG IgG/APC  APC标记的兔抗长爪沙鼠IgG

hz-0403R-AF350 Rabbit anti-MG IgG/Alexa Fluor 350  Alexa Fluor 350标记的兔抗长爪沙鼠IgG

hz-0403R-AF488 Rabbit anti-MG IgG/Alexa Fluor 488  Alexa Fluor 488标记的兔抗长爪沙鼠IgG

hz-0403R-AF555 Rabbit anti-MG IgG/Alexa Fluor 555  Alexa Fluor 555标记的兔抗长爪沙鼠IgG

hz-0403R-AF647 Rabbit anti-MG IgG/Alexa Fluor 647  Alexa Fluor 647标记的兔抗长爪沙鼠IgG

hz-0403R-PE-hzy5.5 Rabbit anti-MG IgG/PE-Cy5.5  PE-Cy5.5标记的兔抗长爪沙鼠IgG

hz-0403R-AP Rabbit anti-MG IgG/AP  碱性磷酸酶（AP）标记的兔抗长爪沙鼠IgG

hz-0403R-Gold Rabbit anti-MG IgG/Gold  胶体金标记的兔抗长爪沙鼠IgG

hz-0403R-HRP Rabbit anti-MG IgG/HRP  辣根过氧化物酶标记的兔抗长爪沙鼠IgG

hz-0777R-HRP Rabbit Anti-Mink IgG/HRP  辣根过氧化物酶标记的兔抗水貂IgG