以下为您提供的是桥粒斑菲素蛋白1抗体的说明书,了解更多关于桥粒斑菲素蛋白1抗体的英文名称,桥粒斑菲素蛋白1抗体别名,桥粒斑菲素蛋白1抗体规格,请看以下详细介绍.
英文名称 Anti-Plakophilin 1
中文名称 桥粒斑菲素蛋白1抗体
别 名 B6P; Band 6 protein; Plakophilin 1 (ectodermal dysplasia/skin fragility syndrome); PKP1_HUMAN.
浓 度 1mg/1ml
规 格 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig
桥粒斑菲素蛋白1抗体的多样性:
抗体的异质性。抗体的组成极为复杂,是由成千上万、多种多样的免疫球蛋白(Ig)分子所组成。这些Ig分子在形状、大小、结构以及氨基酸的组成和排列上,既相似,又有差别。由于有差别,它们的电泳活性就有很大的变化。
因为抗体具有与抗原决定簇相对应的结合部位(抗原结合簇),所以抗体与抗原的结合具有特异性。另一方面,抗体本身是一种蛋白质,具有本身的氨基酸组成、排列和立体结构,对异种动物来说,它又是抗原。各类Ig都具有可用血清学方法检出的抗原特异性,它们表现出不同的血清学类型。
桥粒斑菲素蛋白1抗体的相关产品:
Rabbit Anti-pig IgG/Bio 生物素标记的兔抗猪IgG 0.1ml
Rabbit Anti-pig IgG/Cy3 Cy3标记的兔抗猪IgG 0.1ml
Rabbit Anti-pig IgG/Cy5 Cy5标记的兔抗猪IgG 0.1ml
Rabbit Anti-pig IgG/Cy5.5 Cy5.5标记的兔抗猪IgG 0.1ml
产品类型 一抗
研究领域 心血管 细胞生物 免疫学 神经生物学 信号转导 细胞粘附分子 细胞外基质
蛋白分子量 predicted molecular weight: 83kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human Plakophilin 1
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 Plays a role in formation of desmosomal plaques and is found in desmosomes of most simple and stratified epithelia. Not found in cell types that have non-epithelial desmosomes. Absent in fibroblasts and other connective tissue types, including sarcomas.
Function : Seems to play a role in junctional plaques. Contributes to epidermal morphogenesis.
Subcellular Location : Nucleus. Cell junction, desmosome. Note: Nuclear and associated with desmosomes.
Tissue Specificity : Isoform 2 is widely expressed. Isoform 1 is expressed in stratified squamous, complex, glandular duct and bladder epithelia.
DISEASE : Defects in PKP1 are the cause of ectodermal dysplasia-skin fragility syndrome (EDSFS) [MIM:604536]; also known as McGrath syndrome. Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDSFS is characterized by features of both cutaneous fragility and congenital ectodermal dysplasia affecting abnormalities in other epithelia or tissues. Desmosomes in the skin are small and poorly formed with widening of keratinocyte intercellular spaces and perturbed desmosome/keratin intermediate filament interactions.
Similarity : Belongs to the beta-catenin family.
Contains 9 ARM repeats.
Database links :
UniProtKB/Swiss-Prot: Q13835.2
Entrez Gene: 5317 Human
Entrez Gene: 18772 Mouse
桥粒斑菲素蛋白1抗体Omim: 601975 Human
SwissProt: Q13835 Human
SwissProt: P97350 Mouse
Unigene: 497350 Human
Unigene: 4494 Mouse
(Highlypathogenicporcinereproductiveandrespiratorysyndrome,HPPRRS)在我国广泛流行给养猪业带来了巨大的损失。
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