前列腺酸性磷酸酶抗体

公司前列腺酸性磷酸酶抗体具有高纯度、高效价、高特异性的特点，仅用于科学研究，不可用于临床诊断及药物治疗，可以应用于多种实验。CST、Santa抗体品牌。

英文名称  Anti-Prostatic Acid Phosphatase 

中文名称  前列腺酸性磷酸酶抗体 

别    名  Acid phosphatase prostate; ACP 3; ACP3; ACPP; Ecto-5'-nucleotidase; PAP; PPAP_HUMAN; Prostatic acid phosphatase; Thiamine monophosphatase; TMPase; 5'-NT; 5'-nucleotidase. 

浓    度  1mg/1ml 

规 格  0.2ml/200μg
前列腺酸性磷酸酶抗体的相关产品:

RFPL4A/RNF210  环指蛋白210抗体 0.2ml

RFPL4B/RNF211  环指蛋白211抗体 0.2ml

RFTN2  RFTN2蛋白抗体 0.2ml 

前列腺酸性磷酸酶抗体抗体来源  Rabbit  

克隆类型  polyclonal 

交叉反应  Human, Mouse, Rat, Dog, Horse 

产品类型  一抗    

研究领域  肿瘤 细胞生物 激酶和磷酸酶 肿瘤细胞生物标志物  

蛋白分子量  predicted molecular weight: 41kDa 

性    状  Lyophilized or Liquid 

免 疫 原  KLH conjugated synthetic peptide derived from human Prostatic Acid Phosphatase 

亚    型  IgG 

纯化方法  affinity purified by Protein A 

储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 

产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 Prostatic Acid Phosphatase is Belongs to the histidine acid phosphatase family.Cellular localization;Secreted and Lysosome membrane. Predominantly localized in the plasma membrane but also detected in intracellular vesicles.

Function : A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.

Isoform 2: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling.

Subunit : Homodimer; dimer formation is required for phosphatase activity.

Subcellular Location : Isoform 1: Secreted. Isoform 2: Cell membrane.

Tissue Specificity : Highly expressed in the prostate, restricted to glandular and ductal epithelial cells.

Post-translational modifications : N-glycosylated. High mannose content, partially sialylated and fucosylated biantennary complex. Also fucosylated with partially sialylated triantennary complex oligosaccharides.

Proteolytically cleaved in seminal fluid to produce several peptides. Peptide PAPf39, the most prominent, forms amyloid beta-sheet fibrils, SEVI (semen-derived enhancer of viral infection) which entrap  virions, attach them to target cells and enhance infection. SEVI amyloid fibrils are degraded by polyphenol epigallocatechin-3-gallate (EGCG), a constituent of green tea. Target cell attachment and enhancement of  infection is inhibited by surfen. Al前列腺酸性磷酸酶抗体so similarly boosts XMRV (xenotropic murine leukemia virus-related virus) infection. 

Similarity : Belongs to the histidine acid phosphatase family.

Database links : UniProtKB/Swiss-Prot: P15309.3

公司提供前列腺酸性磷酸酶抗体价格绝对优势，欢迎新老客户来电垂询我公司优质抗体前列腺酸性磷酸酶抗体说明书及报价等。