维生素K依赖的蛋白C轻链抗体形态:液态
抗体纯度: >95% By SDS-PAGE
保存环境:2-8℃ 短期保存或<-20℃长期保存保存 1 年以上,避免反复冻融。
英文名称 Anti-protein C light chain
中文名称 维生素K依赖的蛋白C轻链抗体
维生素K依赖的蛋白C轻链抗体别 名 Protein C; Anticoagulant protein C; Autoprothrombin IIA; Blood coagulation factor XIV; EC 3.4.21.69; PC; PROC; PROC1; Vitamin K dependent protein C precursor; APC; EC 3.4.21.69; PC; proC; PROC_HUMAN; Protein C (inactivator of coagulation factors Va and VIIIa); Vitamin K dependent protein C; Vitamin K-dependent protein C; Vitamin K-dependent protein C light chain.
浓 度 1mg/1ml
规 格 0.2ml/200μg
我们提供抗体来源有人、小鼠、大鼠、兔等动物,规格多样,全国免邮,我们用更安全的方式方法保存及运输维生素K依赖的蛋白C轻链抗体。
本公司专业供应各种进口、国产一抗及二抗,品牌有R&D、Santa Cruz、Bipec、Millipore等国际知名品牌,品种多达7000多种,由于产品的数量众多,产品的宿主、抗原来源及应用范围(WB、IH(F/P)、FC、ELISA、IP、IF等)有所不同。
我们还可以为客户提供BAP31蛋白抗体的纯化和标记服务,具体包括盐析沉淀纯化、Portein A/G纯化、免疫亲和纯化、HRP标记、FITC标记等。
维生素K依赖的蛋白C轻链抗体的详细介绍:
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Rat
产品类型 一抗
研究领域 心血管 细胞生物 免疫学 信号转导
蛋白分子量 predicted molecular weight: 17/46kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human Vitamin K-dependent protein C light chain
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
Human matrilysin,MAT ELISA Kit 人基质裂解蛋白/基质溶素 Multi-class antibodies
Human triple-helical peptide,THP ELISA Kit 人螺旋肽 Multi-class antibodies
Human human lysosomal-associated membrane protein 2,HLAMP-2 ELISA Kit 人溶酶体相关膜蛋白2 Multi-class antibodies
Human Cartilage glycoprotein 39,HC gp-39 ELISA Kit 人软骨糖蛋白39 Multi-class antibodies
Human Opacity-associated proteins,OPAs ELISA Kit 人不透光相关蛋白 Multi-class antibodies
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009].
Function : Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids.
Subunit : Synthesized as a single chain precursor, which is cleaved into a light chain and a heavy chain held together by a disulfide bond. The enzyme is then activated by thrombin, which cleaves a tetradecapeptide from the amino end of the heavy chain; this reaction, which occurs at the surface of endothelial cells, is strongly promoted by thrombomodulin.
Tissue Specificity : Plasma; synthesized in the liver.
Post-translational modifications : The vitamin K-dependent, enzymatic carboxylation of some Glu residues allows the modified protein to bind calcium.
N- and O-glycosylated. Partial (70%) N-glycosylation of Asn-371 with an atypical N-X-C site produces a higher molecular weight form referred to as alpha. The lower molecular weight form, not N-glycosylated at Asn-371, is beta. O-glycosylated with core 1 or possibly core 8 glycans.
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
May be phosphorylated on a Ser or Thr in a region (AA 25-30) of the propeptide.
DISEASE : Defects in PROC are the cause of thrombophilia due to protein C deficiency, autosomal dominant (THPH3) [MIM:176860]. A hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. However, many adults with heterozygous disease may be asymptomatic. Individuals with decreased amounts of protein C are classically referred to as having type I protein C deficiency and those with normal amounts of a functionally defective protein as having type II deficiency.
Defects in PROC are the cause of thrombophilia due to protein C deficiency, autosomal recessive (THPH4) [MIM:612304]. A hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. It results in a thrombotic condition that can manifest as a severe neonatal disorder or as a milder disorder with late-onset thrombophilia. The severe form leads to neonatal death through massive neonatal venous thrombosis. Often associated with ecchymotic skin lesions which can turn necrotic called purpura fulminans, this disorder is very rare.
维生素K依赖的蛋白C轻链抗体Similarity : Belongs to the peptidase S1 family.
Contains 2 EGF-like domains.
Contains 1 Gla (gamma-carboxy-glutamate) domain.
Contains 1 peptidase S1 domain.
Database links : NCBI Reference Sequence: NP_000303
UniProtKB/Swiss-Prot: P04070
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上海谷研生物科技有限公司
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2012-10-24
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