磷酸化非受体酪氨酸激酶c-Abl抗体

磷酸化非受体酪氨酸激酶c-Abl抗体

〖别名〗c-Abl 1/2(phospho Y393/429); c-ABL1/2(phospho Tyr393/429); p-c-ABL1/2(Tyr393/429); tyrosine-protein kinase ABL1 isoform b; Abelson Murine Leukemia Viral Oncogene Homolog 1; Abelson murine leukemia viral v abl oncogene homolog 1; Abl 1; ABL; Abl protein; Abl1; Bcr/c abl oncogene protein; JTK 7; JTK7; p150 ; Proto oncogene tyrosine protein kinase ABL1; Transformation gene oncogene ABL; v abl Abelson murine leukemia viral oncogene homolog 1; v abl; ABL1_HUMAN. 

〖浓度〗1mg/1ml 

〖规格〗0.1ml/100μg 

〖抗体来源〗Rabbit  

〖克隆类型〗polyclonal 

〖交叉反应〗Human, Mouse, Rat, Chicken, Pig, Rabbit, Guinea Pig  

〖产品类型〗磷酸化非受体酪氨酸激酶c-Abl抗体一抗  磷酸化抗体  

〖研究领域〗细胞生物 免疫学 信号转导 细胞凋亡 转录调节因子 激酶和磷酸酶 线粒体  

〖蛋白分子量〗predicted molecular weight: 124kDa 

〖性状〗Lyophilized or Liquid 

〖免疫原〗KLH conjugated Synthesised phosphopeptide derived from human c-Abl isoform a around the phosphorylation site of Tyr393 

〖亚型〗IgG 

〖纯化方法〗affinity purified by Protein A 

〖储存液〗Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 

〖产品应用〗WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:50-200 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

〖保存条件〗Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

〖产品介绍〗The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq].

Function : Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 acts also as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.

Subunit : Interacts with SORBS1 following insulin stimulation. Found in a trimolecular complex containing CDK5 and CABLES1. Interacts with CABLES1 and PSTPIP1. Interacts with ZDHHC16, ITGB1 and HCK (By similarity). Interacts with INPPL1/SHIP2. Interacts with the 14-3-3 proteins, YWHAB, YWHAE, YWHAG, YWHAH, SFN AND YWHAZ; the interaction with 14-3-3 proteins requires phosphorylation on Thr-735 and, sequesters ABL1 into the cytoplasm. Interacts with ABI1, ABI2, BCR, CRK, FGR, FYN, HCK, LYN, PSMA7 RAD9A, RAD51, RAD52, TP73 and WASF3. A complex made of ABL1, CTTN and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement.

Subcellular Location : Cytoplasm, cytoskeleton. Nucleus. Mitochondrion. Note=Shuttles between the nucleus and cytoplasm depending on environmental signals. Sequestered into the cytoplasm through interaction with 14-3-3 proteins. Localizes to mitochondria in response to oxidative stress. Isoform IB: Nucleus membrane; Lipid-anchor. Note=The myristoylated c-ABL protein is reported to be nuclear.

Tissue Specificity : Widely expressed.

Similarity : Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily. 

Contains 1 protein kinase domain. 

Contains 1 SH2 domain. 

Contains 1 SH3 domain.

Database links : NCBI Reference Sequence: NP_009297.2

非受体酪氨酸激酶c-Abl广泛表达于各组织细胞中,c-Abl是非受体酪氨酸激酶Src家族的一个成员。在生理状态下,它可以定位于多个亚细胞结构(如细胞核、细胞质、线粒体等)中并呈现不同功能。经研究认为,细胞核内的c-Abl在细胞凋亡调控以及DNA损伤修复过程中起重要作用,而胞质中的c-Abl则与细胞黏附、细胞分化及氧化应激有关联，该蛋白主要用于细胞凋亡的研究。

本公司产品现货供应,货期短，质量可靠。仅用于科研实验不应用于临床。我们用专业的态度，一流的服务，全程实验指导，让你的数据不在成为实验奇谈。选择优质的磷酸化非受体酪氨酸激酶c-Abl抗体，你的小伙伴都会惊呆的。本公司专业供应各种进口、国产一抗及二抗。代理品牌有R&D、Santa Cruz、Bipec、Millipore等国际知名品牌，品种多达7000多种。让你的科研之路不再布满荆棘。

我们还可以为客户提供产品说明书。磷酸化非受体酪氨酸激酶c-Abl抗体拥有高纯度、高效价、高特异性的特点，可以应用于多种实验。免费送货上门，为您大大节省了时间和金钱。

Ab-(001)-09522 Anti-CSP/FITC 荧光素标记环子孢子蛋白(约氏疟原虫)抗体IgG ，英文名： Anti-CSP/FITC ，规格： 0.2ml

Ab-(001)-09523 Anti-CT/FITC 荧光素标记降钙素抗体IgG ，英文名： Anti-CT/FITC ，规格： 0.2ml

Ab-(001)-09524 Anti-CT-1/CTF1/FITC 荧光素标记心肌营养素1抗体IgG ，英文名： Anti-CT-1/CTF1/FITC ，规格： 0.2ml

Ab-(001)-09525 Anti-CT-R/FITC 荧光素标记降钙素受体抗体IgG ，英文名： Anti-CT-R/FITC ，规格： 0.2ml

Ab-(001)-09526 Anti-CSMD1/FITC 荧光素标记抑癌基因CSMD1抗体IgG ，英文名： Anti-CSMD1/FITC ，规格： 0.2ml

Ab-(001)-09527 Anti-CTBP1/FITC 荧光素标记C端结合蛋白1抗体IgG ，英文名： Anti-CTBP1/FITC ，规格： 0.2ml

Ab-(001)-09528 Anti-CT DNA /FITC 荧光素标记兔抗小牛胸腺DNA 抗体IgG ，英文名： Anti-CT ，规格： 0.2ml

Ab-(001)-09529 Anti-CT DNA /Gold 胶体金标记兔抗小牛胸腺DNA 抗体IgG(10nm/15nm) ，英文名： Anti-CT ，规格： 0.2ml

Ab-(001)-09530 Anti-CTGF/FITC 荧光素标记结缔组织生长因子抗体IgG ，英文名： Anti-CTGF/FITC ，规格： 0.2ml

Ab-(001)-09531 Anti-CTLA-4/CD152 /FITC 荧光素标记淋巴细胞相关抗原4/细胞毒性T细胞抗原-4抗体IgG ，英文名： Anti-CTLA-4/CD152 ，规格： 0.2ml

Ab-(001)-09532 Anti-CTSC/PALS/DPP-I/FITC 荧光素标记组织蛋白酶C抗体IgG ，英文名： Anti-CTSC/PALS/DPP-I/FITC ，规格： 0.2ml

Ab-(001)-09533 Anti-CTn1/FITC 荧光素标记心肌肌钙蛋白抗体IgG ，英文名： Anti-CTn1/FITC ，规格： 0.2ml

Ab-(001)-09534 Anti-cTnT/Troponin T/FITC 荧光素标记心肌特异性肌钙蛋白T抗体IgG ，英文名： Anti-cTnT/Troponin ，规格： 0.2ml

Ab-(001)-09535 Anti-CTNNAL1/FITC 荧光素标记粘附分子相关蛋白a1抗体IgG ，英文名： Anti-CTNNAL1/FITC ，规格： 0.2ml

Ab-(001)-09536 Anti-CULLIN/Cdc53/CUL/SCFCdc4 /FITC 荧光素标记CULLIN抗体IgG ，英文名： Anti-CULLIN/Cdc53/CUL/SCFCdc4 ，规格： 0.2ml

Ab-(001)-09537 Anti-Cullin 4a/FITC 荧光素标记Cullin 4a蛋白抗体IgG ，英文名： Anti-Cullin ，规格： 0.2ml

Ab-(001)-09538 Anti-COMP/EPD1/FITC 荧光素标记软骨寡聚基质蛋白抗体IgG ，英文名： Anti-COMP/EPD1/FITC ，规格： 0.2ml

Ab-(001)-09539 Anti-Cx26/FITC 荧光素标记整合素样间隙连接蛋白26抗体IgG ，英文名： Anti-Cx26/FITC ，规格： 0.2ml

Ab-(001)-09540 Anti-CX3CR1/FITC 荧光素标记抗CX3C趋化因子受体1抗体 ，英文名： Anti-CX3CR1/FITC ，规格： 0.2ml

Ab-(001)-09541 Anti-Cx32/FITC 荧光素标记间隙连接蛋白32抗体IgG ，英文名： Anti-Cx32/FITC ，规格： 0.2ml

Ab-(001)-09542 Anti-CX36 /FITC 荧光素标记间隙连接蛋白36抗体IgG ，英文名： Anti-CX36 ，规格： 0.2ml

Ab-(001)-09543 Anti-Cx40/FITC 荧光素标记间隙连接蛋白40抗体IgG ，英文名： Anti-Cx40/FITC ，规格： 0.2ml

Ab-(001)-09544 Anti-Phospho-Connexin 43 (Ser368) /FITC 荧光素标记兔抗人、大、小鼠等磷酸化Connexin 43蛋白抗体IgG ，英文名： Anti-Phospho-Connexin ，规格： 0.2ml

Ab-(001)-09545 Anti-CX45/FITC 荧光素标记间隙连接蛋白45抗体IgG ，英文名： Anti-CX45/FITC ，磷酸化非受体酪氨酸激酶c-Abl抗体规格： 0.2ml

Ab-(001)-09546 Anti-CXCL4/PF-4/FITC 荧光素标记血小板因子4抗体IgG ，英文名： Anti-CXCL4/PF-4/FITC ，规格： 0.2ml

Ab-(001)-09547 Anti-CXCL5/ENA-78/FITC 荧光素标记上皮中性粒细胞活化肽78抗体IgG ，英文名： Anti-CXCL5/ENA-78/FITC ，规格： 0.2ml