磷酸化有丝分裂激酶B/C抗体

磷酸化有丝分裂激酶B/C抗体

〖别名〗Aurora B (phospho T232); p-Aurora B (phospho T232) ;AIK2; AIM1; ARK2; AurB; AURKB; Aurora 1; Aurora and Ipl1 like midbody associated protein 1; Aurora kinase B; Aurora related kinase 2; Aurora-B; Aurora/IPL1 related kinase 2; IPL1; Serine/theronine kinase 12; Serine/threonine protein kinase 12; STK1; STK12; STK5. 

〖浓度〗1mg/1ml 

〖规格〗0.1ml/100μg  

〖抗体来源〗Rabbit  

〖克隆类型〗磷酸化有丝分裂激酶B/C抗体polyclonal 

〖交叉反应〗Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep   

〖产品类型〗一抗  磷酸化抗体  

〖研究领域〗细胞生物 信号转导 激酶和磷酸酶  

〖蛋白分子量〗predicted molecular weight: 39kDa 

〖性状〗Lyophilized or Liquid 

〖免疫原〗KLH conjugated Synthesised phosphopeptide derived from human Aurora B around the phosphorylation site of Thr232 

〖亚型〗IgG 

〖纯化方法〗affinity purified by Protein A 

〖储存液〗0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide 

〖产品应用〗WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

〖保存条件〗Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

〖产品介绍〗Aurora B is a mitotic protein kinase that phosphorylates histone H3 (probably on Serine 10), behaves as a chromosomal passenger protein, and may regulate several stages of mitosis such as centrosome separation, chromosome segregation and cytokinesis. It localizes to the inner centromere region from prophase to anaphase.

Function : May be directly involved in regulating the cleavage of polar spindle microtubules and is a key regulator for the onset of cytokinesis during mitosis. Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Phosphorylates 'Ser-10' and 'Ser-28' of histone H3 during mitosis. Required for kinetochore localization of BUB1 and SGOL1. Interacts with INCENP.

Subcellular Location : Nucleus. Chromosome. Chromosome > centromere. Cytoplasm > cytoskeleton > spindle. Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalized with gamma tubulin in the mid-body.

Tissue Specificity : High level expression seen in the thymus. It is also expressed in the spleen, lung, testis, colon, placenta and fetal liver. Expressed during S and G2/M phase and expression is up-regulated in cancer cells during M phase.

Post-translational modifications : Ubiquitinated by different BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complexes. Ubiquitinated by the BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex, ubiquitination leads to removal from mitotic chromosomes and is required for cytokinesis. During anaphase, the BCR(KLHL21) E3 ubiquitin ligase complex recruits the CPC complex from chromosomes to the spindle midzone and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome.

DISEASE : Note=Disruptive regulation of expression is a possibile mechanism of the perturbation of chromosomal integrity in cancer cells through its dominant-negative effect on cytokinesis.

Similarity : Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.

Contains 1 protein kinase domain.

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Ab-(001)-08565 Eukaryotic aspartyl protease(Rice) 天冬氨酸蛋白酶家族蛋白(水稻蛋白的一种)（抗原） ，英文名： Eukaryotic ，规格： 0.5mg

Ab-(001)-08566 FAM3B/PANDER(PANcreatic DERived factor) 一种新型的胰岛细胞因子(抗原) ，英文名： FAM3B/PANDER ，规格： 0.5mg

Ab-(001)-08567 Fabp2 (fatty acid binding protein 2, intestinal) 脂肪酸结合蛋白2(抗原) ，英文名： Fabp2 ，规格： 0.5mg

Ab-(001)-08568 ECG2 (sophagus cancer-related gene-2) 食道癌相关基因（抗原） ，英文名： ECG2 ，规格： 0.5mg

Ab-(001)-08569 Fibronectin (FN) 纤维连结蛋白(多肽抗原) ，英文名： Fibronectin ，规格： 0.5mg

Ab-(001)-08570 FGF-7/KGF (Keratinocyte growth factor precursor) 成纤维细胞生长因子-7/纤维母细胞生长因子 (抗原) ，英文名： FGF-7/KGF ，规格： 0.5mg

Ab-(001)-08571 FGFR1 peptide 碱性成纤维细胞生长因子受体-1（多肽抗原） ，英文名： FGFR1 ，规格： 0.5mg

Ab-(001)-08572 FGFR2(Fibroblast Growth Factor Receptor 2) 成纤维细胞生长因子受体2抗原 ，英文名： FGFR2 ，规格： 0.5mg

Ab-(001)-08573 FGF-8/HBGF-8 (Fibroblast growth factor 8) 成纤维细胞生长因子-8/纤维母细胞生长因子-8 (抗原) ，英文名： FGF-8/HBGF-8 ，规格： 0.5mg

Ab-(001)-08574 GAD-65 (glutamate decarboxylase) 谷氨酸脱羧酶-65(C端多肽) ，英文名： GAD-65 ，规格： 0.5mg

Ab-(001)-08575 GAPDH(Ribbt Anti-glyceraldehyde-3-phosphate Dehydrogease ) 3-磷酸甘油醛脱氢酶（抗原） ，英文名： GAPDH ，规格： 0.5mg

Ab-(001)-08576 Galectin-3 半乳糖凝集素-3(抗原) ，英文名： Galectin-3 ，规格： 0.5mg

Ab-(001)-08577 GCS (glucosylceramide synthase, GCS) 葡萄糖神经酰铵合成酶（抗原） ，英文名： GCS ，规格： 0.5mg

Ab-(001)-08578 GFP (Green Fluorecent protein) 绿色荧光蛋白（多肽抗原） ，英文名： GFP ，规格： 0.5mg

Ab-(001)-08579 EGFP protein/rEGFP/Recombinant EGFP(Enhanced Green Fluorecent protein) 重组增强型绿色荧光蛋白 ，英文名： EGFP ，规格： 100ug

Ab-(001)-08580 GHR (growth hormone receptor) 生长激素受体(抗原) ，英文名： GHR ，规格： 0.5mg

Ab-(001)-08581 GLUT1(Glucose transporter type 1) 葡萄糖转运蛋白1（抗原） ，英文名： GLUT1 ，规格： 0.5mg

Ab-(001)-08582 hypothetical protein (LOC55652) hypothetical protein 抗原 ，英文名： hypothetical ，规格： 0.5mg

Ab-(001)-08583 HCCR-1(BRI3 binding protein) 人宫颈癌基因/bri3结合蛋白(抗原) ，英文名： HCCR-1 ，规格： 0.5mg

Ab-(001)-08584 pre S1/S2 protein [HBV] 乙肝病毒pre S1/乙肝病毒pre S2(抗原) ，英文名： pre ，规格： 0.5mg

Ab-(001)-08585 HCV-HCBP1/ACY-3(Hepatitis C virus core-binding protein 1) 丙型肝炎病毒核心蛋白结合蛋白-1（抗原） ，英文名： HCV-HCBP1/ACY-3 ，规格： 0.5mg

Ab-(001)-08586 HHV8/ORF50(Human herpesvirus 8 type P) 人类疱疹病毒8抗原 ，英文名： HHV8/ORF50 ，规格： 0.5mg

Ab-(001)-08587 HHV8/ORF K2/vIL-6(Human herpesvirus 8) 人类疱疹病毒8抗原 ，英文名： HHV8/ORF ，规格： 0.5mg

Ab-(001)-08588 HIF-1Alpha (Hypoxia-inducible factor -1Alpha) 缺氧诱导因子1α （抗原） ，英文名： HIF-1Alpha ，规格： 0.5mg

Ab-(001)-08589 HIV gp41 艾滋病病毒（抗原） ，英文名： HIV ，规格： 0.5ml

Ab-(001)-08590 histone H3-like protein 抗组蛋白H3样抗原 ，英文名： histone ，规格： 0.5mg

Ab-(001)-08591 histone H3-like protein 抗组蛋白H3样蛋白（C端抗原） ，英文名： histone ，规格： 0.5mg

Ab-(001)-08592 histone H3-like protein 抗组蛋白H3样蛋白（N端抗原） ，英文名： histone ，规格： 0.5mg

Ab-(001)-08593 HIV-1(human immunodeficiency virus type 1) 艾滋病病毒-1/人类免疫缺陷病毒1型(抗原) ，英文名： HIV-1 ，磷酸化有丝分裂激酶B/C抗体规格： 0.5mg

Ab-(001)-08594 HIV-1(human immunodeficiency virus type 1) 艾滋病病毒-1/人类免疫缺陷病毒1型(抗原) ，英文名： HIV-1 ，规格： 0.5mg

Ab-(001)-08595 Measles virus protein(Plant2 derived measles virus hemagglutinin protein) 麻疹病毒红血球凝集素蛋白多肽 ，英文名： Measles ，规格： 0.5mg