磷酸化间变型淋巴瘤激酶抗体

磷酸化间变型淋巴瘤激酶抗体

〖别名〗ALK (Phospho-Tyr1586); ALK(phospho-Y1586); p-ALK(Tyr1586); p-ALK(Y1586); ALK tyrosine kinase receptor precursor; ALK/EML4 fusion gene, included; ALK/NPM1 fusion gene, included; anaplastic lymphoma kinase (Ki-1); Anaplastic lymphoma kinase; Anaplastic lymphoma kinase Ki 1; Anaplastic lymphoma kinase Ki1; Anaplastic lymphoma kinase p80 CD 246; CD246; CD246 antigen; EC 2.7.10.1 Ki 1; Ki1; NBLST3; Tcrz; TFG/ALK; ALK_HUMAN. 

〖浓度〗1mg/1ml 

〖规格〗0.1ml/100μg  

〖抗体来源〗Rabbit  

〖克隆类型〗polyclonal 

〖交叉反应〗Human, Mouse, Rat, Chicken, Cow, Horse 

〖产品类型〗磷酸化间变型淋巴瘤激酶抗体一抗  磷酸化抗体  

〖研究领域〗肿瘤 神经生物学 信号转导 生长因子和激素 激酶和磷酸酶 通道蛋白  

〖蛋白分子量〗predicted molecular weight: 174kDa 

〖性状〗Lyophilized or Liquid 

〖免疫原〗KLH conjugated Synthesised phosphopeptide derived from human ALK around the phosphorylation site of Tyr1586 

〖亚型〗IgG 

〖纯化方法〗affinity purified by Protein A 

〖储存液〗0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide 

〖产品应用〗WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

〖保存条件〗Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

〖产品介绍〗This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), LK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011].

Function : Neuronal orphan receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction. Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK.

Subunit : Homodimer. Homodimerizes when bound to ligand. Interacts with FRS2, IRS1, MDK, PTN and SHC1. Interacts with CBL, PIK3R1 and PLCG1.

Subcellular Location : Cell membrane; Single-pass type I membrane protein. Note=Membrane attachment was crucial for promotion of neuron-like differentiation and cell proliferation arrest through specific activation of the MAP kinase pathway. 

Tissue Specificity : Expressed in brain and CNS. Also expressed in the small intestine and testis, but not in normal lymphoid cells.

Post-translational modifications : Phosphorylated at tyrosine residues by autocatalysis, which activates kinase activity. In cells not stimulated by a ligand, receptor protein tyrosine phosphatase beta and zeta complex (PTPRB/PTPRZ1) dephosphorylates ALK at the sites in ALK that are undergoing autophosphorylation through autoactivation. 

N-glycosylated. 

DISEASE : Note=A chromosomal aberration involving ALK is found in a form of non-Hodgkin lymphoma. Translocation t(2;5)(p23;q35) with NPM1. The resulting chimeric NPM1-ALK protein homodimerize and the kinase becomes constitutively activated. The constitutively active fusion proteins are responsible for 5-10% of non-Hodgkin lymphomas. 

Note=A chromosomal aberration involving ALK is associated with inflammatory myofibroblastic tumors (IMTs). Translocation t(2;11)(p23;p15) with CARS; translocation t(2;4)(p23;q21) with SEC31A. [DISEASE] Note=A chromosomal aberration involving ALK is associated with anaplastic large-cell lymphoma (ALCL). Translocation t(2;17)(p23;q25) with ALO17. 

Neuroblastoma 3 (NBLST3) [MIM:613014]: A common neoplasm of early childhood arising from embryonic cells that form the primitive neural crest and give rise to the adrenal medulla and the sympathetic nervous system. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. 

Note=The ALK signaling pathway plays an important role in glioblastoma, the most common malignant brain tumor of adults and one of the most lethal cancers. It regulates both glioblastoma migration and growth. 

Similarity : Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. 

Contains 1 LDL-receptor class A domain. 

Contains 2 MAM domains. 

Contains 1 protein kinase domain. 

Database links : NCBI Reference Sequence: NP_004295 

UniProtKB/Swiss-Prot: Q9UM73

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Ab-(001)-07787 TmR2(GDNFR Beta；TRN-R；GFR-alpha-2；NTNR-2) 胶质细胞系源性神经营养因子（多肽） ，英文名： TmR2 ，规格： 0.5mg

Ab-(001)-07788 TNF-Alpha(Tumor Necrosis Factor-Alpha) 人肿瘤坏死因子-α（多肽抗原） ，英文名： TNF-Alpha ，规格： 0.5mg

Ab-(001)-07789 TRA16 (Testicular orphan nuclear receptor-4 (TR4)-associated protein) 睾丸激素受体相关蛋白 ，英文名： TRA16 ，规格： 0.5mg

Ab-(001)-07790 Tranthyretin 甲状腺素运载蛋白（抗原） ，英文名： Tranthyretin ，规格： 0.5mg

Ab-(001)-07791 TrK A (h-NGFR) (p140- TrK A) 神经生长因子的一种（抗原） ，英文名： TrK ，规格： 0.5mg

Ab-(001)-07792 TrK A.B.C 神经生长因子的一种（抗原） ，英文名： TrK ，规格： 0.5mg

Ab-(001)-07793 active Caspase 3(caspase-3 p12 subunit) 活化半胱铵酸蛋白酶蛋白-3抗原 ，英文名： active ，规格： 0.5mg

Ab-(001)-07794 CASP4(Caspase-4) 半胱铵酸蛋白酶蛋白-4抗原 ，英文名： CASP4 ，规格： 0.5mg

Ab-(001)-07795 Trk B 神经生长因子受体的一种（抗原） ，英文名： Trk ，规格： 0.5mg

Ab-(001)-07796 Trk B 神经生长因子受体的一种（抗原） ，英文名： Trk ，规格： 0.5mg

Ab-(001)-07797 Trk C 神经生长因子受体的一种（抗原） ，英文名： Trk ，规格： 0.5mg

Ab-(001)-07798 TSHR (Thyroid stimulating hormone receptor)(NT) 促甲状腺素受体（抗原） ，英文名： TSHR ，规格： 0.5mg

Ab-(001)-07799 Caspase-8 (pro Mch5) 半胱氨酸蛋白酶8抗原 ，英文名： Caspase-8 ，规格： 0.5mg

Ab-(001)-07800 TSHR (Thyroid stimulating hormone receptor)(CT) 促甲状腺素受体（抗原） ，英文名： TSHR ，规格： 0.5mg

Ab-(001)-07801 TY3H ( Tyrosine Hydroxylase ) 酪氨酸羟化酶（抗原） ，英文名： TY3H ，规格： 0.5mg

Ab-(001)-07802 Tubulin-Alpha 微管蛋白（抗原） ，英文名： Tubulin-Alpha ，规格： 0.5mg

Ab-(001)-07803 Cav-1/ETM1 peptide 细胞质膜微囊蛋白-1抗原 ，英文名： Cav-1/ETM1 ，规格： 0.5mg

Ab-(001)-07804 Beta-catenin/ Beta-cats β-连环蛋白抗原（β-β链接素） ，英文名： Beta-catenin/ ，规格： 0.5mg

Ab-(001)-07805 p- Beta catenin(p-beta Catenin(phosphor-Y142)) 磷酸化β-连环蛋白抗原 ，英文名： p- ，规格： 0.5mg

Ab-(001)-07806 Tubulin- Beta 微管蛋白（抗原） ，英文名： Tubulin- ，规格： 0.5mg

Ab-(001)-07807 NAIF1 protein( CB12-327) 核凋亡诱导因子蛋白1(多肽) ，英文名： NAIF1 ，规格： 0.5mg

Ab-(001)-07808 cath-B/CB(Cathepsin B) 组织蛋白酶B抗原 ，英文名： cath-B/CB ，规格： 0.5mg

Ab-(001)-07809 cath-L/CL peptide 组织蛋白酶L抗原 ，英文名： cath-L/CL ，规格： 0.5mg

Ab-(001)-07810 CBFA1/RUNX2 (Runt-related Transcription Factor 2) 成骨特异性转录因子（多肽） ，英文名： CBFA1/RUNX2 ，规格： 0.5mg

Ab-(001)-07811 CBP(CREB-binding protein) CREB结合蛋白抗原 ，英文名： CBP ，规格： 0.5mg

Ab-(001)-07812 CBX3/HP1 gamma homolog(Chromobox homolog 3) 染色盒同源物3抗原 ，英文名： CBX3/HP1 ，规格： 0.5mg

Ab-(001)-07813 CBX5(Chromobox Homolog 5) CBX5（多肽） ，英文名： CBX5 ，规格： 0.5mg

Ab-(001)-07814 CCR-2/5(CC chemokine receptor 2/5) CC趋化因子受体2/5抗原 ，英文名： CCR-2/5 ，规格： 0.5mg

Ab-(001)-07815 CCL1/TCA3/I-309 嗜酸粒细胞趋化蛋白CCL1抗原 ，英文名： CCL1/TCA3/I-309 ，规格： 0.5mg

Ab-(001)-07816 CCL5/RANTES(regulated on activation normal T cell expressed and secreted) 活化T细胞表达和分泌的调节因子抗原 ，英文名： CCL5/RANTES ，规格： 0.5mg

Ab-(001)-07817 CCL4/MIP-1 Beta(Macrophage Inflammatory Protein 1 beta) 巨噬细胞炎性蛋白1β抗原 ，英文名： CCL4/MIP-1 ，规格： 0.5mg

Ab-(001)-07818 MIP3 Alpha/CCL20(Macrophage inflammatory ptotein 3 alpha) 巨噬细胞炎性蛋白3α抗原 ，英文名： MIP3 ，规格： 0.5mg

Ab-(001)-07819 CCL12/MCP-5(C-C motif chemokine 12) 单核细胞趋化蛋白5抗原 ，英文名： CCL12/MCP-5 ，规格： 0.5mg

Ab-(001)-07820 CCL14/HCC-1(C-C motif chemokine 14) 嗜酸粒细胞趋化蛋白14抗原 ，英文名： CCL14/HCC-1 ，规格： 0.5mg

Ab-(001)-07821 ABCD-1/CCL22 嗜酸粒细胞趋化蛋白22抗原 ，英文名： ABCD-1/CCL22 ，规格： 0.2mg

Ab-(001)-07822 MIP-3 beta/ELC/CCL19(Macrophage Inflammatory Protein 3 Beta) 巨噬细胞炎性蛋白19抗原 ，英文名： MIP-3 ，规格： 0.5mg

Ab-(001)-07823 CCL26(Eotaxin 3) 嗜酸粒细胞趋化蛋白3抗原 ，英文名： CCL26 ，规格： 0.5mg

Ab-(001)-07824 CCR-1(CC chemokine receptor 1) 细胞表面趋化因子受体1抗原 ，英文名： CCR-1 ，规格： 0.5mg

Ab-(001)-07825 CCR-3(CC chemokine receptor 3) CC趋化因子受体3抗原 ，英文名： CCR-3 ，规格： 0.5mg

Ab-(001)-07826 CCR-2A(C-C Chemokine receptor 2A) 细胞表面趋化因子受体2A抗原 ，英文名： CCR-2A ，规格： 0.5mg

Ab-(001)-07827 CCR-4(C-C chemokine receptor 4) 细胞表面趋化因子受体4抗原 ，英文名： CCR-4 ，规格： 0.5mg

Ab-(001)-07828 CCR-6/CD196 peptide 细胞表面趋化因子受体6抗原 ，英文名： CCR-6/CD196 ，规格： 0.5mg

Ab-(001)-07829 CXCR6(CXC-chemokine receptor 6) peptide 细胞表面趋化因子受体6抗原 ，英文名： CXCR6 ，规格： 0.5mg

Ab-(001)-07830 CCR-7(CC chemokine receptor 7) CC趋化因子受体7（多肽） ，英文名： CCR-7 ，磷酸化间变型淋巴瘤激酶抗体规格： 0.5mg

Ab-(001)-07831 CXCL10/IP-10 CXCL10趋化因子10/干扰素诱导蛋白10抗原 ，英文名： CXCL10/IP-10 ，规格： 0.5mg

Ab-(001)-07832 VEGF(Vascular endothelial growth factor) 血管内皮生长因子（多肽抗原） ，英文名： VEGF ，规格： 0.5mg