三磷酸腺苷结合转运蛋白G超家族成员8抗体
〖别名〗ATP binding cassette sub family G (WHITE) member 8 (sterolin 2); ATP binding cassette sub family G member 8; MGC142217; Sterolin 2; STSL; ABCG8_HUMAN.
〖浓度〗1mg/1ml
〖规格〗0.2ml/200μg
〖抗体来源〗三磷酸腺苷结合转运蛋白G超家族成员8抗体Rabbit
〖克隆类型〗polyclonal
〖交叉反应〗Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit
〖产品类型〗一抗
〖研究领域〗肿瘤 细胞生物 免疫学 转录调节因子 转运蛋白
〖蛋白分子量〗predicted molecular weight: 76kDa
〖性状〗Lyophilized or Liquid
〖免疫原〗KLH conjugated synthetic peptide derived from human ABCG8
〖亚型〗IgG
〖纯化方法〗affinity purified by Protein A
〖储存液〗0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
〖产品应用〗WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
〖保存条件〗Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
〖产品介绍〗The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions to exclude non-cholesterol sterol entry at the intestinal level, promote excretion of cholesterol and sterols into bile, and to facilitate transport of sterols back into the intestinal lumen. It is expressed in a tissue-specific manner in the liver, intestine, and gallbladder. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG5. Mutations in this gene may contribute to sterol accumulation and atherosclerosis, and have been observed in patients with sitosterolemia. [provided by RefSeq, Jul 2008].
Function : Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile.
Subunit : May form heterodimers with ABCG5 or be tightly coupled to ABCG5 along a pathway regulating diatery-sterol absorption and excretion.
Subcellular Location : Membrane; Multi-pass membrane protein (Probable).
Tissue Specificity : Strongly expressed in the liver, lower levels in the small intestine and colon. Detectable in a wide variety of human tissues.
DISEASE : Genetic variations in ABCG8 can be associated with susceptibility to gallbladder disease type 4 (GBD4) [MIM:611465]. With an overall prevalence of 10-20%, gallstone disease (cholelithiasis) represents one of the most frequent and economically relevant health problems of industrialized countries.
Defects in ABCG8 are a cause of sitosterolemia (STSL) [MIM:210250]; also known as phytosterolemia or shellfish sterolemia. It is a rare autosomal recessive disorder characterized by increased intestinal absorption of all sterols including cholesterol, plant and shellfish sterols, and decreased biliary excretion of dietary sterols into bile. Sitosterolemia patients have hypercholesterolemia, very high levels of plant sterols in the plasma, and frequently develop tendon and tuberous xanthomas, accelerated atherosclerosis and premature coronary artery disease.
Similarity : Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
Contains 1 ABC transmembrane type-2 domain.
Contains 1 ABC transporter domain.
Database links : UniProtKB/Swiss-Prot: Q9H221.1
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Ab-(001)-07480 Actin Alpha /Alpha-SMA (Actin alpha , smooth muscle aorta) 肌动蛋白(抗原) ,英文名: Actin ,规格: 0.5mg
Ab-(001)-07481 AEBP1 (Adipocyte enhance binding protein 1) 脂肪细胞增强结合蛋白1 ,英文名: AEBP1 ,规格: 0.5mg
Ab-(001)-07482 MMP-9(matrix metalloproteinase 9) 基质金属蛋白酶-9(抗原) ,英文名: MMP-9 ,规格: 0.5mg
Ab-(001)-07483 AGER(Advanced glycosylation end product-specific receptor) 晚期糖基化终末产物特异性受体(抗原) ,英文名: AGER ,规格: 0.5mg
Ab-(001)-07484 AIF (Apoptosis-Inducing Factor) 调亡诱导因子(多肽片断抗原) ,英文名: AIF ,规格: 0.5mg
Ab-(001)-07485 Adenylate Kinase 1 (AK-1) 腺苷酸激酶-1 ,英文名: Adenylate ,规格: 0.5mg
Ab-(001)-07486 Akt/PKB 蛋白激酶B(抗原) ,英文名: Akt/PKB ,规格: 0.5mg
Ab-(001)-07487 2,4-D/KLH(2,4-Dichlorophenoxyacetic acid) 2,4-二氯苯氧乙酸偶联血蓝蛋白 ,英文名: 2,4-D/KLH ,规格: 5mg
Ab-(001)-07488 2,4-D/BSA 2,4-二氯苯氧乙酸偶联牛血清白蛋白 ,英文名: 2,4-D/BSA ,规格: 5mg
Ab-(001)-07489 Akt/PKB 蛋白激酶B(抗原) ,英文名: Akt/PKB ,规格: 0.5mg
Ab-(001)-07490 ALK (Anaplastic Lymphoma Kinase)(CD246Ag) 间变型淋巴瘤激酶(抗原) ,英文名: ALK ,规格: 0.5mg
Ab-(001)-07491 5-HT(5-Hydroxy-L-tryptophan/L-5-HTP) 5-羟色铵 ,英文名: 5-HT ,规格: 50mg
Ab-(001)-07492 AM (Adrenomedullin; ADM) 肾上腺髓质素(多肽抗原) ,英文名: AM ,规格: 0.1mg
Ab-(001)-07493 5-HTR1A (5-HT1A (5-hydroxytryptamine/serotonin receptor 1A; 5HT1a; ADRBRL1; ADRB2RL1; HTR1A) 5-羟色铵受体1A(多肽) ,英文名: 5-HTR1A ,规格: 0.5mg
Ab-(001)-07494 TIMP-2(Tissue Inhibitor of Metalloproteinase-2) 金属蛋白酶组织抑制因子-2(抗原) ,英文名: TIMP-2 ,规格: 0.5mg
Ab-(001)-07495 TIMP-3(Tissue Inhibitor of Metalloproteinase-3) 金属蛋白酶组织抑制因子(抗原) ,英文名: TIMP-3 ,规格: 0.5mg
Ab-(001)-07496 ADM R, Adrenomedullin receptor 肾上腺髓质素受体(抗原) ,英文名: ADM ,规格: 0.5mg
Ab-(001)-07497 VTG(vitellogenin) 青鳉鱼卵黄蛋白 ,英文名: VTG ,规格: 0.1mg
Ab-(001)-07498 Apaf-1 (Apoptosis protease activating factor-1)(CT) 凋亡蛋白活性因子-1(抗原) ,英文名: Apaf-1 ,规格: 0.5mg
Ab-(001)-07499 Apaf-1 (Apoptosis protease activating factor-1)(NT) 凋亡蛋白活性因子-1(抗原) ,英文名: Apaf-1 ,规格: 0.5mg
Ab-(001)-07500 AR (Androgen Receptor)peptide 雄激素受体(多肽抗原) ,英文名: AR ,规格: 0.5mg
Ab-(001)-07501 5-HTR2A 5-羟色铵受体2A抗原 ,英文名: 5-HTR2A ,规格: 0.5mg
Ab-(001)-07502 5-HTR3(5-hydroxytryptamine (serotonin) receptor 3a) 5-羟色铵受体3抗原 ,英文名: 5-HTR3 ,规格: 0.5mg
Ab-(001)-07503 5-HTR4(5 hydroxytryptamine serotonin receptor 4) 5-羟色铵受体4抗原 ,英文名: 5-HTR4 ,规格: 0.5mg
Ab-(001)-07504 AT (Angiotenogen) 血管紧张素原(抗原) ,英文名: AT ,规格: 0.5mg
Ab-(001)-07505 5-LOX (5-lipoxygenase) 5-脂氧合酶抗原 ,英文名: 5-LOX ,规格: 0.5mg
Ab-(001)-07506 Apo-E (Apolipoprotein E) 载脂蛋白E(抗原) ,英文名: Apo-E ,规格: 0.5mg
Ab-(001)-07507 IKI3 family protein ,英文名: IKI3 ,规格: 0.5mg
Ab-(001)-07508 ILK-1 (Integrin-linked protein kinase 1) 整合素连接激酶-1 ,英文名: ILK-1 ,规格: 0.5mg
Ab-(001)-07509 Aromatase 芳香化酶(抗原) ,英文名: Aromatase ,规格: 0.5mg
Ab-(001)-07510 ART(Artemin)(抗原) ,英文名: ART ,规格: 0.5mg
Ab-(001)-07511 AATK peptide 细胞凋亡关联酪氨酸激酶抗原 ,英文名: AATK ,规格: 0.5mg
Ab-(001)-07512 AQP-2 (aquaporin Protein-2) 水通道蛋白-2(抗原) ,英文名: AQP-2 ,规格: 0.5mg
Ab-(001)-07513 ABCA1(ATP binding cassette transporter A1) 腺苷三磷酸结合盒转运体A1抗原 ,英文名: ABCA1 ,规格: 0.5mg
Ab-(001)-07514 ABCG1 peptide 三磷酸腺苷结合盒亚家族G1抗原 ,英文名: ABCG1 ,规格: 0.5mg
Ab-(001)-07515 BACE( ASP2 ) β分泌酶(抗原) ,英文名: BACE ,规格: 0.5mg
Ab-(001)-07516 ABL1(v-abl Abelson murine leukemia viral oncogene homolog 1) ABL1抗原 ,英文名: ABL1 ,规格: 0.5mg
Ab-(001)-07517 Bassoon(BSN) ,英文名: Bassoon ,规格: 0.5mg
Ab-(001)-07518 Bax peptide Bax(多肽抗原) ,英文名: Bax ,规格: 0.5mg
Ab-(001)-07519 Bcl-2(抗原) Bcl-2(多肽抗原) ,英文名: Bcl-2 ,规格: 0.5mg
Ab-(001)-07520 BDNF (Brain-derived Neurotrophin factor) 脑源神经营养因子(脑衍化神经营养因子)(多肽片断抗原) ,英文名: BDNF ,规格: 0.5mg
Ab-(001)-07521 ACA11 peptide 拟南芥ACA11蛋白多肽抗原 ,英文名: ACA11 ,规格: 0.5mg
Ab-(001)-07522 AHA3 peptide 植物蛋白AHA3抗原(拟南芥) ,英文名: AHA3 ,规格: 0.5mg
Ab-(001)-07523 bFGF 碱性成纤维细胞生长因子(多肽抗原) ,英文名: bFGF ,三磷酸腺苷结合转运蛋白G超家族成员8抗体规格: 0.5mg
Ab-(001)-07524 ACE2(Angiotensin converting enzyme 2) 血管紧张素转换酶2抗原 ,英文名: ACE2 ,规格: 0.5mg
Ab-(001)-07525 BNP 脑钠素(多肽抗原) ,英文名: BNP ,规格: 0.5mg