磷酸化雄激素受体抗体

磷酸化雄激素受体抗体

〖别名〗Androgen Receptor (phospho S515); Androgen Receptor (Phospho-Ser515); Androgen Receptor (phospho Ser515); p-Androgen Receptor (Ser515); ANDR_HUMAN; HYSP1; AIS; Androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease); AR; DHTR; Dihydro Testosterone Receptor; Dihydrotestosterone receptor; HUMARA; Nuclear receptor subfamily 3 group C member 4; SBMA; SMAX1; Spinal and bulbar muscular atrophy; TFM. 

〖浓度〗1mg/1ml 

〖规格〗0.1ml/100μg   

〖抗体来源〗Rabbit  

〖克隆类型〗磷酸化雄激素受体抗体polyclonal 

〖交叉反应〗Human  

〖产品类型〗一抗  磷酸化抗体  

〖研究领域〗肿瘤 细胞生物 发育生物学 染色质和核信号 信号转导 表观遗传学  

〖蛋白分子量〗predicted molecular weight: 99kDa 

〖性状〗Lyophilized or Liquid 

〖免疫原〗KLH conjugated synthesised phosphopeptide derived from human Androgen Receptor around the phosphorylation site of Ser515  

〖亚型〗IgG 

〖纯化方法〗affinity purified by Protein A 

〖储存液〗Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 

〖产品应用〗WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

〖保存条件〗Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

〖产品介绍〗Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3.

Function : Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3.

Subunit : Binds DNA as a homodimer. Part of a ternary complex containing AR, EFCAB6/DJBP and PARK7. Interacts with HIPK3 and NR0B2 in the presence of androgen. The ligand binding domain interacts with KAT7/HBO1 in the presence of dihydrotestosterone. Interacts with EFCAB6/DJBP, PELP1, PQBP1, RANBP9, RBAK, SPDEF, SRA1, TGFB1I1, ZNF318 and RREB1. Interacts with ZMIZ1/ZIMP10 and ZMIZ2/ZMIP7 which both enhance its transactivation activity. Interacts with SLC30A9 and RAD54L2/ARIP4. Interacts via the ligand-binding domain with LXXLL and FXXLF motifs from NCOA1, NCOA2, NCOA3, NCOA4 and MAGEA11. The AR N-terminal poly-Gln region binds Ran resulting in enhancement of AR-mediated transactivation. Ran-binding decreases as the poly-Gln length increases. Interacts with HIP1 (via coiled coil domain). Interacts (via ligand-binding domain) with TRIM68. Interacts with TNK2. Interacts with USP26. Interacts with RNF6. Interacts (regulated by RNF6 probably through polyubiquitination) with RNF14; regulates AR transcriptional activity. Interacts with PRMT2 and TRIM24. Interacts with GNB2L1/RACK1. Interacts with RANBP10; this interaction enhances dihydrotestosterone-induced AR transcriptional activity. Interacts with PRPF6 in a hormone-independent way; this interaction enhances dihydrotestosterone-induced AR transcriptional activity. Interacts with STK4/MST1. Interacts with ZIPK/DAPK3. Interacts with LPXN. Interacts with MAK. Part of a complex containing AR, MAK and NCOA3.

Subcellular Location : Nucleus. Cytoplasm. Predominantly cytoplasmic in unliganded form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unliganded form in the presence of GNB2L1.

Tissue Specificity : Isoform 2 is mainly expressed in heart and skeletal muscle.

Post-translational modifications : Sumoylated on Lys-386 (major) and Lys-520. Ubiquitinated. Deubiquitinated by USP26. 'Lys-6' and 'Lys-27'-linked polyubiquitination by RNF6 modulates AR transcriptional activity and specificity.

Phosphorylated in prostate cancer cells in response to several growth factors including EGF. Phosphorylation is induced by c-Src kinase (CSK). Tyr-534 is one of the major phosphorylation sites and an increase in phosphorylation and Src kinase activity is associated with prostate cancer progression. Phosphorylation by TNK2 enhances the DNA-binding and transcriptional activity and may be responsible for androgen-independent progression of prostate cancer.

DISEASE : Defects in AR are the cause of androgen insensitivity syndrome (AIS) [MIM:300068]; previously known as testicular feminization syndrome (TFM). AIS is an X-linked recessive form of pseudohermaphroditism due end-organ resistance to androgen. Affected males have female external genitalia, female breast development, blind vagina, absent uterus and female adnexa, and abdominal or inguinal testes, despite a normal 46,XY karyotype.

Defects in AR are the cause of spinal and bulbar muscular atrophy X-linked type 1 (SMAX1) [MIM:313200]; also known as Kennedy disease. SMAX1 is an X-linked recessive form of spinal muscular atrophy. Spinal muscular atrophy refers to a group of neuromuscular disorders characterized by degeneration of the anterior horn cells of the spinal cord, leading to symmetrical muscle weakness and atrophy. SMAX1 occurs only in men. Age at onset is usually in the third to fifth decade of life, but earlier involvement has been reported. It is characterized by slowly progressive limb and bulbar muscle weakness with fasciculations, muscle atrophy, and gynecomastia. The disorder is clinically similar to classic forms of autosomal spinal muscular atrophy. Note=Caused by trinucleotide CAG repeat expansion. In SMAX1 patients the number of Gln ranges from 38 to 62. Longer expansions result in earlier onset and more severe clinical manifestations of the disease.

Note=Defects in AR may play a role in metastatic prostate cancer. The mutated receptor stimulates prostate growth and metastases development despite of androgen ablation. This treatment can reduce primary and metastatic lesions probably by inducing apoptosis of tumor cells when they express the wild-type receptor.

Defects in AR are the cause of androgen insensitivity syndrome partial (PAIS) [MIM:312300]; also known as Reifenstein syndrome. PAIS is characterized by hypospadias, hypogonadism, gynecomastia, genital ambiguity, normal XY karyotype, and a pedigree pattern consistent with X-linked recessive inheritance. Some patients present azoospermia or severe oligospermia without other clinical manifestations

Similarity : Belongs to the nuclear hormone receptor family. NR3 subfamily.

Contains 1 nuclear receptor DNA-binding domain.

Database links : UniProtKB

本公司产品现货供应,货期短，质量可靠。仅用于科研实验不应用于临床。我们用专业的态度，一流的服务，全程实验指导，让你的数据不在成为实验奇谈。选择优质的磷酸化雄激素受体抗体，你的小伙伴都会惊呆的。本公司专业供应各种进口、国产一抗及二抗。代理品牌有R&D、Santa Cruz、Bipec、Millipore等国际知名品牌，品种多达7000多种。让你的科研之路不再布满荆棘。

我们还可以为客户提供产品说明书。磷酸化雄激素受体抗体拥有高纯度、高效价、高特异性的特点，可以应用于多种实验。免费送货上门，为您大大节省了时间和金钱。

Ab-(001)-01433 Anti-Axin1 轴蛋白1抗体 ，英文名： Anti-Axin1 ，规格： 0.2ml

Ab-(001)-01434 Anei-ATX 自分泌运动因子抗体 ，英文名： Anei-ATX ，规格： 0.2ml

Ab-(001)-01435 Anti-Aurora A 有丝分裂激酶A抗体 ，英文名： Anti-Aurora ，规格： 0.2ml

Ab-(001)-01436 Anti-Aurora B 有丝分裂激酶B抗体 ，英文名： Anti-Aurora ，规格： 0.2ml

Ab-(001)-01437 Anti-Aurora C 有丝分裂激酶B抗体 ，英文名： Anti-Aurora ，规格： 0.2ml

Ab-(001)-01438 Anti-Aurora A/B/C 有丝分裂激酶A/B/C抗体 ，英文名： Anti-Aurora ，规格： 0.2ml

Ab-(001)-01439 Anti-B7-H1/CD274 程序性死亡配体1抗体 ，英文名： Anti-B7-H1/CD274 ，规格： 0.1ml

Ab-(001)-01440 Anti-B7-DC/CD273 程序性死亡配体2抗体 ，英文名： Anti-B7-DC/CD273 ，规格： 0.1ml

Ab-(001)-01441 Anti-ICOS-L/B7-H2/CD275 诱导协同刺激分子配体CD275抗体 ，英文名： Anti-ICOS-L/B7-H2/CD275 ，规格： 0.1ml

Ab-(001)-01442 Anti-B7H4 B7-H4抗体 ，英文名： Anti-B7H4 ，规格： 0.1ml

Ab-(001)-01443 Anti-BACE/ASP2 β分泌酶抗体 ，英文名： Anti-BACE/ASP2 ，规格： 0.2ml

Ab-(001)-01444 Anti-Bad 相关死亡促进因子Bad抗体 ，英文名： Anti-Bad ，规格： 0.1ml

Ab-(001)-01445 Anti-Bad 相关死亡促进因子Bad抗体 ，英文名： Anti-Bad ，规格： 0.1ml

Ab-(001)-01446 Anti-phospho-BAD(Ser128) 磷酸化相关死亡促进因子抗体 ，英文名： Anti-phospho-BAD ，规格： 0.1ml

Ab-(001)-01447 Anti-phospho-BAD(Ser75/99/118) 磷酸化相关死亡促进因子抗体 ，英文名： Anti-phospho-BAD ，规格： 0.1ml

Ab-(001)-01448 Anti-Bag1/RAP46 抑凋亡基因bag1抗体 ，英文名： Anti-Bag1/RAP46 ，规格： 0.1ml

Ab-(001)-01449 Anti-Bak Bcl-2同源拮抗剂抗体 ，英文名： Anti-Bak ，规格： 0.1ml

Ab-(001)-01450 Anti-BADH2 BADH2抗体(水稻) ，英文名： Anti-BADH2 ，规格： 0.2ml

Ab-(001)-01451 Anti-Bassoon 锌指蛋白231抗体 ，英文名： Anti-Bassoon ，规格： 0.2ml

Ab-(001)-01452 Anti-Batroxobin 蛇毒巴曲酶抗体 ，英文名： Anti-Batroxobin ，规格： 0.2ml

Ab-(001)-01453 Anti-Batroxobin 蛇毒蛋白巴曲酶抗体 ，英文名： Anti-Batroxobin ，规格： 0.2ml

Ab-(001)-01454 Anti-Bax Bax ，英文名： Anti-Bax ，规格： 0.1ml

Ab-(001)-01455 Anti-Bax Bax抗体 ，英文名： Anti-Bax ，规格： 0.1ml

Ab-(001)-01456 Anti-phospho-Bax(Ser184) 磷酸化Bax抗体 ，英文名： Anti-phospho-Bax ，规格： 0.1ml

Ab-(001)-01457 Anti-phospho-Bcl 10(Ser218) 磷酸化Bcl-10抗体 ，英文名： Anti-phospho-Bcl ，规格： 0.1ml

Ab-(001)-01458 Anti-Bcl-2 Bcl-2抗体 ，英文名： Anti-Bcl-2 ，规格： 0.1ml

Ab-(001)-01459 Anti-Phospho-Bcl-2 (Ser70) 磷酸化Bcl-2抗体 ，英文名： Anti-Phospho-Bcl-2 ，规格： 0.1ml

Ab-(001)-01460 Anti-Phospho-Bcl-2 (Thr56) 磷酸化Bcl-2抗体 ，英文名： Anti-Phospho-Bcl-2 ，规格： 0.1ml

Ab-(001)-01461 Anti-Phospho-Bad(Ser112) 磷酸化相关死亡促进因子抗体 ，英文名： Anti-Phospho-Bad ，规格： 0.1ml

Ab-(001)-01462 Anti-Phospho-Bad(Ser136) 磷酸化相关死亡促进因子抗体 ，英文名： Anti-Phospho-Bad ，规格： 0.1ml

Ab-(001)-01463 Anti-Phospho-Bad(Ser155) 磷酸化相关死亡促进因子抗体 ，英文名： Anti-Phospho-Bad ，规格： 0.1ml

Ab-(001)-01464 Anti-Bcl-6/5 原癌基因Bcl-6抗体 ，英文名： Anti-Bcl-6/5 ，规格： 0.2ml

Ab-(001)-01465 Anti-Bcl-10/CLAP Bcl-10抗体 ，英文名： Anti-Bcl-10/CLAP ，规格： 0.2ml

Ab-(001)-01466 Anti-Bcl-xL Bcl-xL蛋白抗体 ，英文名： Anti-Bcl-xL ，规格： 0.1ml

Ab-(001)-01467 Anti-BBC3/PUMA p53正向细胞凋亡调控因子抗体 ，英文名： Anti-BBC3/PUMA ，规格： 0.1ml

Ab-(001)-01468 Anti-phospho-Bcl-xL(Ser62) 磷酸化Bcl-xL(pSer62)抗体 ，英文名： Anti-phospho-Bcl-xL ，规格： 0.1ml

Ab-(001)-01469 Anti-BCHE (NT) 丁酰胆碱酯酶抗体(N端) ，英文名： Anti-BCHE ，规格： 0.1ml

Ab-(001)-01470 Anti-BCHE 丁酰胆碱酯酶单克隆抗体 ，英文名： Anti-BCHE ，规格： 0.2ml

Ab-(001)-01471 Anti-BCHE (CT) 丁酰胆碱酯酶抗体(C端) ，英文名： Anti-BCHE ，规格： 0.2ml

Ab-(001)-01472 Anti-BDNF 脑源神经营养因子抗体 ，英文名： Anti-BDNF ，规格： 0.1ml

Ab-(001)-01473 Anti-BECN1 BECLIN-1抗体 ，英文名： Anti-BECN1 ，规格： 0.1ml

Ab-(001)-01474 Anti-Beta-casein β-酪蛋白抗体 ，英文名： Anti-Beta-casein ，规格： 0.2ml

Ab-(001)-01475 Anti-BAFF/CD257 TNF家族B细胞激活因子抗体 ，英文名： Anti-BAFF/CD257 ，规格： 0.2ml

Ab-(001)-01476 Anti-BAFFR/CD268 B细胞活化因子受体抗体 ，英文名： Anti-BAFFR/CD268 ，规格： 0.2ml

Ab-(001)-01477 Anti-bFGF/FGF-2 碱性成纤维细胞生长因子抗体 ，英文名： Anti-bFGF/FGF-2 ，规格： 0.1ml

Ab-(001)-01478 Anti-BGP 骨保护蛋白/骨钙素抗体 ，英文名： Anti-BGP ，规格： 0.1ml

Ab-(001)-01479 Anti-Bid BH3结构域凋亡诱导蛋白抗体 ，英文名： Anti-Bid ，规格： 0.2ml

Ab-(001)-01480 Anti-BIN1 桥连整合因子蛋白抗体 ，英文名： Anti-BIN1 ，规格： 0.2ml

Ab-(001)-01481 Anti-Bim 细胞死亡调解子抗体 ，英文名： Anti-Bim ，规格： 0.2ml

Ab-(001)-01482 Anti-phospho-Bim(Ser87) 磷酸化细胞死亡调解子抗体 ，英文名： Anti-phospho-Bim ，规格： 0.1ml

Ab-(001)-01483 Anti-phospho-Bim(Ser55) 磷酸化细胞死亡调解子抗体 ，英文名： Anti-phospho-Bim ，规格： 0.1ml

Ab-(001)-01484 Anti-phospho-Bim(Ser69) 磷酸化细胞死亡调解子抗体 ，磷酸化雄激素受体抗体英文名： Anti-phospho-Bim ，规格： 0.1ml

Ab-(001)-01485 Anti-BIRC5/Survivin variant 细胞凋亡抑制因子5抗体 ，英文名： Anti-BIRC5/Survivin ，规格： 0.2ml

Ab-(001)-01486 Anti-BK channel BK通道蛋白抗体 ，英文名： Anti-BK ，规格： 0.1ml